Sperm selection by swim-up in terms of deoxyribonucleic acid fragmentation as measured by the sperm chromatin dispersion test is altered in heavy smokers

Viloria, Thamara; Garrido, Nicolás; Fernández, José Luis; Remohí, José; Pellicer, Antonio; Meseguer, Marcos

doi:10.1016/j.fertnstert.2006.11.135

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Volume 88, Issue 2 , Pages 523-525, August 2007

Sperm selection by swim-up in terms of deoxyribonucleic acid fragmentation as measured by the sperm chromatin dispersion test is altered in heavy smokers

Thamara Viloria, Ph.D.
- Instituto Valenciano de Infertilidad, Valencia, Universidad de Valencia, Valencia, Spain
- Reprint requests: Thamara Viloria, Ph.D., Instituto Valenciano de Infertilidad, Valencia, Universidad de Valencia, In Vitro Vertilization Laboratory, Plaza de la Policía Local 3, Valencia 46015, Spain (FAX: 34-96-305-0999).
Nicolás Garrido, Ph.D.
- Instituto Valenciano de Infertilidad, Valencia, Universidad de Valencia, Valencia, Spain
José Luis Fernández, M.D.
- Sección de Genetica y Unidad de Investigación, Hospital “Teresa Herrera,” Complejo Hospitalario Universitario Juan Canalejo, A Coruña, Spain
José Remohí, M.D.
- Instituto Valenciano de Infertilidad, Valencia, Universidad de Valencia, Valencia, Spain
Antonio Pellicer, M.D.
- Instituto Valenciano de Infertilidad, Valencia, Universidad de Valencia, Valencia, Spain
- Department of Obstetrics and Gynaecology, Hospital Dr. Peset, Valencia, Spain
Marcos Meseguer, Ph.D.
- Instituto Valenciano de Infertilidad, Valencia, Universidad de Valencia, Valencia, Spain

Received 7 April 2006; received in revised form 16 August 2006; accepted 21 November 2006. published online 08 May 2007.

Toxic habits and their relationship with male factor infertility have been a matter of investigation in recent years, and smoking is one of the most common lifestyle toxic exposures to harmful substances. The analysis of sperm deoxyribonucleic acid fragmentation after capacitation detected a detrimental effect produced by tobacco, and this deleterious effect alters the sperm swim-up selection process in smokers, although the molecular and cellular basis of this phenomenon remain to be elucidated.