Ovarian hyperstimulation after a short course of an oral contraceptive in a patient with premature ovarian failure
Received 10 March 2008; received in revised form 18 March 2008; accepted 18 March 2008. published online 12 June 2008.
Objective
To report a patient with premature ovarian failure who, after discontinuing a short course of therapy with an oral contraceptive, demonstrated clinical and biochemical evidence of ovarian hyperstimulation.
Design
Case report.
Setting
Reproductive Center at a university hospital.
Patient(s)
31-year-old woman with premature ovarian failure.
Intervention(s)
Triggered ovulation using recombinant human chorionic gonadotropin (hCG).
Main Outcome Measure(s)
Follicle sizes documented by transvaginal ultrasound and corresponding serum estradiol levels.
Result(s)
Hyperstimulated ovaries, documented by pelvic ultrasound, demonstrated lead follicles of 16, 22, 27, and 46 mm in average diameters. The serum estradiol level was 979 pg/mL with a serum progesterone of 0.87 ng/mL. Five days after triggered ovulation with recombinant hCG, serum progesterone levels rose to 13.8 ng/mL.
Conclusion(s)
Ovarian hyperstimulation may occur after brief gonadotropin suppression in women with premature ovarian failure.
Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology and Infertility, Emory University School of Medicine, Atlanta, Georgia
Reprint requests: Caleb B. Kallen, M.D., Ph.D., Emory University School of Medicine, Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology and Infertility, 1639 Pierce Drive, WMB 4211, Atlanta, GA 30322 (FAX: 404-727-8609).
P.K.B. has nothing to disclose. C.B.K. has nothing to disclose.
ABSTRACT