Fertility and Sterility
Volume 91, Issue 4, Supplement , Pages 1420-1423, April 2009

Expressions of steroid receptors and Ki67 in first-trimester decidua and chorionic villi exposed to levonorgestrel used for emergency contraception

  • Chun-Xia Meng, M.D.

      Affiliations

    • Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    • The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    • ,
  • Li-Nan Cheng, M.D.

      Affiliations

    • The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    • ,
  • Parameswaran Grace Luther Lalitkumar, Ph.D.

      Affiliations

    • Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Lin Zhang, M.D.

      Affiliations

    • The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    • ,
  • Hui-Juan Zhang, M.D.

      Affiliations

    • The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    • ,
  • Kristina Gemzell-Danielsson, M.D., Ph.D.

      Affiliations

    • Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    • Corresponding Author InformationReprint requests: Kristina Gemzell-Danielsson, M.D., Ph.D., WHO-Collaborating Center, C1:05, Karolinska University Hospital, 17176, Stockholm, Sweden (FAX: 46-8-51774314).

Received 1 February 2008; received in revised form 6 May 2008; accepted 15 May 2008. published online 19 August 2008.

Levonorgestrel (1.5 mg) is commonly used for emergency contraception to prevent an unwanted pregnancy after an unprotected intercourse. We found that postovulatory administration of 1.5 mg of levonorgestrel to women with a subsequent or existing early pregnancy did not affect the immunohistochemical expressions of estrogen receptors (ERα, ERβ), P receptors (PRB, PRA+B), androgen receptor (AR), or proliferation index Ki67 in the first-trimester decidua and chorionic villi.

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 C.-X.M. has nothing to disclose. L.-N.C. has nothing to disclose. P.G.L.L.K. has nothing to disclose. L.Z. has nothing to disclose. H.-J.Z. has nothing to disclose. K.G.-D. has nothing to disclose.

 Li-Nan Cheng and Kristina Gemzell-Danielsson contributed equally to the study.

 Supported by Chinese Committee of Population and Family Planning (2004BA709B11) and Swedish Medical Research Council (K2007-54X-14212-06-3) and Stockholm City County, Karolinska Institutet (ALF).

PII: S0015-0282(08)01165-5

doi:10.1016/j.fertnstert.2008.05.058

Fertility and Sterility
Volume 91, Issue 4, Supplement , Pages 1420-1423, April 2009

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