Expressions of steroid receptors and Ki67 in first-trimester decidua and chorionic villi exposed to levonorgestrel used for emergency contraception
Received 1 February 2008; received in revised form 6 May 2008; accepted 15 May 2008. published online 19 August 2008.
Levonorgestrel (1.5 mg) is commonly used for emergency contraception to prevent an unwanted pregnancy after an unprotected intercourse. We found that postovulatory administration of 1.5 mg of levonorgestrel to women with a subsequent or existing early pregnancy did not affect the immunohistochemical expressions of estrogen receptors (ERα, ERβ), P receptors (PRB, PRA+B), androgen receptor (AR), or proliferation index Ki67 in the first-trimester decidua and chorionic villi.
aDepartment of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
bThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Reprint requests: Kristina Gemzell-Danielsson, M.D., Ph.D., WHO-Collaborating Center, C1:05, Karolinska University Hospital, 17176, Stockholm, Sweden (FAX: 46-8-51774314).
C.-X.M. has nothing to disclose. L.-N.C. has nothing to disclose. P.G.L.L.K. has nothing to disclose. L.Z. has nothing to disclose. H.-J.Z. has nothing to disclose. K.G.-D. has nothing to disclose.
Li-Nan Cheng and Kristina Gemzell-Danielsson contributed equally to the study.
Supported by Chinese Committee of Population and Family Planning (2004BA709B11) and Swedish Medical Research Council (K2007-54X-14212-06-3) and Stockholm City County, Karolinska Institutet (ALF).
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