Article InfoFigure 1
Flow diagram of systematic review of literature. Tx = treatment; ISP− = isolated soy protein depleted of isoflavones; n = number of treatment groups.
Figure 2
Mean change difference per SD of testosterone.
Figure 3
Mean change difference per SD of SBHG.
Objective
To determine whether isoflavones exert estrogen-like effects in men by lowering bioavailable T through evaluation of the effects of soy protein or isoflavone intake on T, sex hormone–binding globulin (SHBG), free T, and free androgen index (FAI) in men.
Design
PubMed and CAB Abstracts databases were searched through July 1, 2008, with use of controlled vocabulary specific to the databases, such as soy, isoflavones, genistein, phytoestrogens, red clover, androgen, testosterone, and SHBG. Peer-reviewed studies published in English were selected if [1] adult men consumed soy foods, isolated soy protein, or isoflavone extracts (from soy or red clover) and [2] circulating T, SHBG, free T, or calculated FAI was assessed. Data were extracted by two independent reviewers. Isoflavone exposure was abstracted directly from studies.
Main Outcome Measure(s)
Fifteen placebo-controlled treatment groups with baseline and ending measures were analyzed. In addition, 32 reports involving 36 treatment groups were assessed in simpler models to ascertain the results.
Result(s)
No significant effects of soy protein or isoflavone intake on T, SHBG, free T, or FAI were detected regardless of statistical model.
Conclusion(s)
The results of this meta-analysis suggest that neither soy foods nor isoflavone supplements alter measures of bioavailable T concentrations in men.
J.H.-R while a doctoral student at the University of Minnesota received some minor funding from the Soy Nutrition Institute for work on this manuscript. G.V. has nothing to disclose. S.J.D. has nothing to disclose. W.R.P. has nothing to disclose. M.S.K. occasionally consults for the Solae Company. M.J.M. regularly consults for companies in the soy food industry.
