Fertility and Sterility
Volume 93, Issue 7 , Pages 2453-2455, 1 May 2010

Robust embryo identification using first polar body single nucleotide polymorphism microarray-based DNA fingerprinting

  • Nathan R. Treff, Ph.D.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Science, UMDNJ–Robert Wood Johnson Medical School, New Brunswick, New Jersey
    • Corresponding Author InformationReprint requests: Nathan R. Treff, Ph.D., 111 Madison Ave, Suite 100, Morristown, NJ 07960 (FAX: 973-290-8370).
    • ,
  • Jing Su, M.Sc.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • ,
  • Natasha Kasabwala, B.A.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • ,
  • Xin Tao, M.Sc.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • ,
  • Kathleen A. Miller, B.Sc.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • ,
  • Richard T. Scott Jr., M.D., H.C.L.D.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Science, UMDNJ–Robert Wood Johnson Medical School, New Brunswick, New Jersey

Received 13 July 2009; received in revised form 27 August 2009; accepted 31 August 2009. published online 06 November 2009.

This study sought to validate a novel, minimally invasive system for embryo tracking by single nucleotide polymorphism microarray-based DNA fingerprinting of the first polar body. First polar body–based assignments of which embryos implanted and were delivered after multiple ET were 100% consistent with previously validated embryo DNA fingerprinting–based assignments.

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 N.R.T., K.A.M., and R.T.S. are supported by grants from EMD Serono, Schering-Plough, Ferring Pharmaceuticals, and Barr Pharmaceuticals. J.S. has nothing to disclose. N.K. has nothing to disclose. X.T. has nothing to disclose.

PII: S0015-0282(09)03624-3

doi:10.1016/j.fertnstert.2009.08.070

Fertility and Sterility
Volume 93, Issue 7 , Pages 2453-2455, 1 May 2010

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