Fertility and Sterility
Volume 94, Issue 1 , Pages 384-386, June 2010

Genotype and haplotype determination of interleukin (IL) 1β (g. −511C>T and g. +3954C>T) and IL-1RN in polycystic ovary syndrome

  • Yan Yang, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, People's Republic of China
    • ,
  • Jie Qiao, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, People's Republic of China
    • Corresponding Author InformationReprint requests: Jie Qiao, M.D., Department of Obstetrics and Gynecology, Peking University Third Hospital, No. 49 HuaYuan Bei Road, HaiDian District, Beijing, China 100083 (FAX: 86-10-62013283).
    • ,
  • Rong-Xin Tang, M.Sc.

      Affiliations

    • Department of Obstetrics and Gynecology, Lanzhou University First Hospital, Lanzhou, People's Republic of China
    • ,
  • Mei-zhi Li, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, People's Republic of China

Received 10 August 2008; received in revised form 4 September 2009; accepted 18 September 2009. published online 11 November 2009.

The distribution of genotype frequencies, allele frequencies, and haplotype frequencies of variable number of tandem repeats (VNTR) in interleukin (IL) 1RN and IL-1β (−511C > T, exon-5C.>T) polymorphism demonstrated a positive association with the occurrence of polycystic ovary syndrome (PCOS). The carriage of allele V of IL-1RN and allele E1 of exon-5 on the IL-1β gene may increase the risk of PCOS.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

 Y.Y. has nothing to disclose. J.Q. has nothing to disclose. R.-X.T. has nothing to disclose. M.L. has nothing to disclose.

 Supported by National Key Technology R&D Program (2007BA104B00), Beijing, China.

PII: S0015-0282(09)03791-1

doi:10.1016/j.fertnstert.2009.09.042

Fertility and Sterility
Volume 94, Issue 1 , Pages 384-386, June 2010

Article Tools

* Image Usage & Resolution