Live birth after polar body array comparative genomic hybridization prediction of embryo ploidy—the future of IVF?
Received 10 July 2009; received in revised form 25 September 2009; accepted 27 September 2009. published online 24 November 2009.
Objective
To ascertain meiotic aneuploidy of the human egg using array comparative genomic hybridization to evaluate the 23–paired chromosome copy number of first polar body as an objective prognosticator of embryo viability for embryo transfer in the same cycle.
Design
Case report.
Setting
Independent-sector IVF program.
Patient(s)
A 41-year-old woman with a history of 13 failed cycles of IVF.
Intervention(s)
Polar body biopsy of metaphase II eggs.
Main Outcome Measure(s)
Birth.
Result(s)
Two of the nine eggs were euploid, and the resulting embryos, although morphologically inferior to sibling embryos, were selected for transfer to the uterus, resulting in the birth of a normal healthy baby.
Conclusion(s)
Selection of euploid eggs, as an objective parameter of subsequent embryo viability and with the opportunity to transfer embryos in the same cycle could maximise the opportunity for live birth after IVF even in cases with poor prognosis.
Reprint requests: Simon Fishel, Ph.D., CARE Fertility, John Webster House, 6 Lawrence Drive, Nottingham Business Park, Nottingham NG8 6PZ, United Kingdom (FAX: 44 115 967 0381).
S.F. has nothing to disclose. A.G. has nothing to disclose. C.L. has nothing to disclose. K.D. has nothing to disclose. G.N. has nothing to disclose. E.K. has nothing to disclose. S.T. has nothing to disclose. L.J. has nothing to disclose. E.C. has nothing to disclose. A.B. has nothing to disclose. J.G.-B. has nothing to disclose.
ABSTRACT