Fertility and Sterility
Volume 94, Issue 2 , Pages 781-783.e1, July 2010

Epigenetics in polycystic ovary syndrome: a pilot study of global DNA methylation

  • Ning Xu, M.D., Ph.D.

      Affiliations

    • Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California
    • ,
  • Ricardo Azziz, M.D., M.B.A., M.P.H.

      Affiliations

    • Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California
    • Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California
    • Department of Obstetrics and Gynecology, The David Geffen School of Medicine at UCLA, Los Angeles, California
    • ,
  • Mark O. Goodarzi, M.D., Ph.D.

      Affiliations

    • Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California
    • Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California
    • Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California
    • Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California
    • Corresponding Author InformationReprint requests: Mark O. Goodarzi, M.D., Ph.D., Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Room B-131, Los Angeles, California 90048 (FAX: 310-423-0440).

Received 21 August 2009; received in revised form 8 October 2009; accepted 12 October 2009. published online 24 November 2009.

The percent global methylation of peripheral blood DNA was not significantly altered in 20 women with polycystic ovary syndrome (PCOS) compared with 20 controls. The study of specific tissues and target genomic regions will be required to further determine whether epigenetic alteration influences the development of PCOS.

Key Words: Epigenetics, DNA methylation, polycystic ovary syndrome

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 N.X. has nothing to disclose. R.A. has nothing to disclose. M.O.G. has nothing to disclose.

 This study was supported in part by National Institutes of Health grant nos. R01-HD29364 and K24-HD01346 (to RA), R01-DK79888 (to MOG), and M01-RR00425 (General Clinical Research Center Grant from the National Center for Research Resources [NCRR]); the Cedars-Sinai Winnick Clinical Scholars Award (to MOG) and an endowment from the Helping Hand of Los Angeles, Inc.

PII: S0015-0282(09)03882-5

doi:10.1016/j.fertnstert.2009.10.020

Fertility and Sterility
Volume 94, Issue 2 , Pages 781-783.e1, July 2010

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