Fertility and Sterility
Volume 94, Issue 5 , Pages 1739-1743, October 2010

Overweight and seminal quality: a study of 794 patients

  • Ana C. Martini, Ph.D.

      Affiliations

    • Established investigator from the Consejo Nacional de Investigaciones Científicas y Tecnológicas; Instituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina
    • Corresponding Author InformationReprint requests: Ana C. Martini, Ph.D., Instituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, X5000ESU, Córdoba, Argentina (TEL and FAX: 54-351-4332019).
    • ,
  • Andrea Tissera, B.S.

      Affiliations

    • Laboratorio de Andrología y Reproducción; Córdoba, Argentina
    • ,
  • Daniel Estofán, M.D.

      Affiliations

    • Centro Integral de Ginecología, Obstetricia y Reproducción; Córdoba, Argentina
    • ,
  • Rosa I. Molina, B.S.

      Affiliations

    • Centro Integral de Ginecología, Obstetricia y Reproducción; Córdoba, Argentina
    • ,
  • Arnaldo Mangeaud, Ph.D.

      Affiliations

    • Cátedra de Estadística y Biometría, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, Argentina
    • ,
  • Marta Fiol de Cuneo, M.D., Ph.D.

      Affiliations

    • Established investigator from the Consejo Nacional de Investigaciones Científicas y Tecnológicas; Instituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina
    • ,
  • Rubén D. Ruiz, M.D., Ph.D.

      Affiliations

    • Established investigator from the Consejo Nacional de Investigaciones Científicas y Tecnológicas; Instituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

Received 3 July 2009; received in revised form 5 November 2009; accepted 9 November 2009. published online 07 January 2010.

Objectives

To evaluate sperm quality, levels of markers of epididymal and accessory gland function, and T in semen from men grouped according to their body mass index (BMI).

Design

Blind prospective study.

Setting

Andrology and reproduction laboratory in Cordoba, Argentina (2006–2007).

Patient(s)

Seven hundred ninety-four men.

Intervention(s)

None.

Main Outcome Measure(s)

In semen samples, sperm quality (volume, density, motility, morphology, viability, hypoosmotic swell test, and nuclear maturity) and levels of neutral alpha-glucosidase, fructose, citric acid and T.

Result(s)

Multivariate analysis showed a negative association between BMI and motility, rapid motility and neutral alpha-glucosidase levels, and a positive association between BMI and seminal fructose levels. No associations were found among BMI and sperm concentration, the other parameters evaluated, or seminal T levels.

Conclusion(s)

Results found in our study support a deleterious effect of obesity on seminal quality, probably by alterations in the function of the epididymis (i.e., in epididymal maturation).

Key Words: Overweight, obesity, sperm quality, epididymis, seminal T, neutral alpha-glucosidase, fructose, citric acid

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 Supported by grants from the Secretaría de Ciencia y Tecnología, Universidad Nacional de Córdoba.

 A.C.M. has nothing to disclose. A.T. has nothing to disclose. D.E. has nothing to disclose. R.I.M. has nothing to disclose. A.M. has nothing to disclose. M.F.C. has nothing to disclose. R.D.R has nothing to disclose.

PII: S0015-0282(09)04046-1

doi:10.1016/j.fertnstert.2009.11.017

Fertility and Sterility
Volume 94, Issue 5 , Pages 1739-1743, October 2010

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