Fertility and Sterility
Volume 96, Issue 2 , Pages 516-518, August 2011

Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfers in high responders

  • Bruce S. Shapiro, M.D., Ph.D.

      Affiliations

    • Fertility Center of Las Vegas, Las Vegas, Nevada
    • Department of Obstetrics and Gynecology, University of Nevada School of Medicine, Las Vegas, Nevada
    • Corresponding Author InformationReprint requests: Bruce S. Shapiro, M.D., Ph.D., Fertility Center of Las Vegas, 8851 W. Sahara Avenue, Las Vegas, NV 89117.
    • ,
  • Said T. Daneshmand, M.D.

      Affiliations

    • Fertility Center of Las Vegas, Las Vegas, Nevada
    • Department of Obstetrics and Gynecology, University of Nevada School of Medicine, Las Vegas, Nevada
    • ,
  • Forest C. Garner, M.Sc.

      Affiliations

    • Fertility Center of Las Vegas, Las Vegas, Nevada
    • Department of Obstetrics and Gynecology, University of Nevada School of Medicine, Las Vegas, Nevada
    • ,
  • Martha Aguirre, Ph.D.

      Affiliations

    • Fertility Center of Las Vegas, Las Vegas, Nevada
    • ,
  • Cynthia Hudson, M.S.

      Affiliations

    • Fertility Center of Las Vegas, Las Vegas, Nevada
    • ,
  • Shyni Thomas, B.Sc.

      Affiliations

    • Fertility Center of Las Vegas, Las Vegas, Nevada

Received 8 November 2010; received in revised form 31 January 2011; accepted 1 February 2011. published online 06 July 2011.

Clinical pregnancy rates of 80% and 65% were observed in cycles using thawed and fresh embryos, respectively, although embryo quality indicators revealed morphologically and numerically inferior embryo cohorts after cryopreservation. Subsequent logistic regression analysis controlled for differences in embryo quality and revealed significantly greater probability of clinical pregnancy with thawed embryos when compared with fresh, suggesting a negative effect of ovarian stimulation on endometrial receptivity.

Key Words: Embryo cryopreservation, IVF, blastocyst transfer, endometrium, endometrial receptivity, ovarian stimulation

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 B.S.S. has nothing to disclose. S.T.D. has nothing to disclose. F.C.G. has nothing to disclose. M.A. has nothing to disclose. C.H. has nothing to disclose. S.T. has nothing to disclose.

 Supported in part by a research grant from the Investigator-Initiated Studies Program of Merck Sharp & Dohme Corporation.

PII: S0015-0282(11)00861-2

doi:10.1016/j.fertnstert.2011.02.059

Fertility and Sterility
Volume 96, Issue 2 , Pages 516-518, August 2011

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