Fertility and Sterility
Volume 75, Issue 2 , Pages 310-315 , February 2001

Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone

Presented in part at the annual meeting of the American Society of Reproductive Medicine, Toronto, Ontario, Canada, September 7–10, 1999.

  • David T Vandermolen, M.D. (a)

      Affiliations

    • Medical College of Virginia of Virginia Commonwealth University, Department of Obstetrics and Gynecology, Medical College of Virgini, Virginia Commonwealth University, Richmond, Virginia, USA
    • Corresponding Author InformationReprint requests: David T. Vandermolen, M.D., Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center–Shreveport, Box 33932, Shreveport, Louisiana 71130 (FAX: 318-675-5670)
    • ,
  • Valerie S Ratts, M.D. (b)

      Affiliations

    • Washington University, Department of Obstetrics and Gynecology, Washington University, St. Louis, Missouri, USA
    • ,
  • William S Evans, M.D. (c)

      Affiliations

    • University of Virginia, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia, USA
    • ,
  • Dale W Stovall, M.D. (a)

      Affiliations

    • Medical College of Virginia of Virginia Commonwealth University, Department of Obstetrics and Gynecology, Medical College of Virgini, Virginia Commonwealth University, Richmond, Virginia, USA
    • ,
  • Scott W Kauma, M.D. (a)

      Affiliations

    • Medical College of Virginia of Virginia Commonwealth University, Department of Obstetrics and Gynecology, Medical College of Virgini, Virginia Commonwealth University, Richmond, Virginia, USA
    • ,
  • John E Nestler, M.D.

      Affiliations

    • University of Virginia, Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA

Received 10 May 2000 ,Revised 1 August 2000 ,Accepted 1 August 2000.

References 

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  19. Nestler JE, Jakubowicz DJ. Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 activity and serum androgens. J Clin Endocrinol Metab. 1997;82:4075–4079
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  25. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. National Diabetes Group. Diabetes. 1979;28:1039–1057
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☆ Supported by the National Institute of Child Health and Human Development, National Institutes of Health, through cooperative agreement U54HD96008 as part of the Specialized Cooperative, and by National Institutes of Health grants M01RR00065 and M01RR0036.

PII: S0015-0282(00)01675-7

Fertility and Sterility
Volume 75, Issue 2 , Pages 310-315 , February 2001

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