Fertility and Sterility
Volume 75, Issue 2 , Pages 282-287 , February 2001

The insulin-like growth factor-I system and hormone replacement therapy

  • Hilton José Pereira Cardim, M.D. (a)

      Affiliations

    • aHospital Regional Universitário de Maringá, São Paulo, Brazil
    • Corresponding Author InformationReprint requests: Hilton José Pereira Cardim, M.D., Rua Joaquim Nabuco, 163–apt. 602, Zona 1, 87013-340 Maringá, Paraná, Brazil (FAX: 55-44-224-6964)
    • ,
  • Ceci Mendes Carvalho Lopes, M.D. (b)

      Affiliations

    • bGynecology Department, University of São Paulo School of Medicine, São Paulo, Brazil
    • ,
  • Daniel Giannella-Neto, M.D. (c)

      Affiliations

    • cCellular and Molecular Endocrinology Section, Laboratory for Human Nutrition and Metabolic Diseases (LIM-25/HC), University of São Paulo School of Medicine, São Paulo, Brazil
    • ,
  • Angela Maggio da Fonseca, M.D. (b)

      Affiliations

    • bGynecology Department, University of São Paulo School of Medicine, São Paulo, Brazil
    • ,
  • José Aristodemo Pinotti (M.D.b)

      Affiliations

    • bGynecology Department, University of São Paulo School of Medicine, São Paulo, Brazil

Received 3 May 2000 ,Accepted 27 September 2000.

References 

  1. Duursma SA, Bijlsma JWJ, Van Paassen HC, Buul-Offers SC, Skottner-Lundin A. Changes in serum somatomedin and growth factor hormone concentrations after 3 weeks oestrogen substitution in post-menopausal women (a pilot study). Acta Endocrinol. 1984;106:527–531
  2. Dawson-Hughes B, Stern D, Goldman J, Reichlin S. Regulation of growth hormone and somatomedin-C secretion in postmenopausal women: effect of physiological estrogen replacement. J Clin Endocrinol Metab 1986;63:424–32.
  3. Fröhlander N, Von Schoultz B. Growth hormone and somatomedin C during postmenopausal replacement therapy with oestrogen alone and in combination with an antioestrogen. Maturitas. 1988;9:297–302
  4. Weissberger AJ, Ho KKY, Lazarus L. Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone (growth hormone) secretion, insulin-like growth factor-I, and growth hormone-binding protein in postmenopausal women. J Clin Endocrinol Metab. 1991;72:374–381
  5. Ho KKY, Weissberger AJ, Impact of short-term estrogen administration on growth hormone secretion and action: distinct route-dependent effects on connective and bone tissue metabolism. J Bone Miner Res 1992;7:821–7.
  6. Kelly JJ, Rajkovic IA, O’Sullivan AJ, Servia C, Ho KKY. Effects of different oral estrogen growth hormone and growth hormone binding protein in post-menopausal women. Clin Endocrinol. 1993;39:561–567
  7. Campagnolli C, Biglia N, Altare F, Lanza MG, Lesca L, Cantamessa C, et al.  Differential effects of oral conjugated estrogens and transdermal estradiol on insulin-like growth factor I, growth hormone and sex hormone binding globulin serum levels. Gynecol Endocrinol. 1993;7:251–257
  8. Bellantoni MF, Vittone J, Campfield AT, Bass KM, Harman SM, Blackman MR. Effects of oral versus transdermal estrogen on the growth hormone/insulin-like growth factor 1 axis in younger and older postmenopausal women (a clinical research center study). J Clin Endocrinol Metab. 1996;81:2848–2853
  9. Slowinska-Srzednicka J, Zgliczynski S, Jeske W, Stopinska-Gluszak U, Srzerdniicki M, Brzezinska A, et al.  Trandermal 17β-estradiol combined with oral progestagen increases plasma levels of insulin-like growth factor-I in postmenopausal women. J Endocrinol Invest. 1992;15:533–538
  10. Bellantoni MF, Harman SM, Cho DE, Blackman MR. Effects of progestin-opposed transdermal estrogen administration on growth hormone and insulin-like growth factor-1 in postmenopausal women of different ages. J Clin Endocrinol Metab. 1991;72:172–178
  11. Dall’aglio E, Valenti G, Hoffman AR, Zucarelli A, Passeri M, Ceda GP. Lack of effect of trandermal estrogen on the growth hormone-insulin-like growth factor axis. Horm Metab Res. 1994;26:211–212
  12. Campagnoli C, Biglia N, Lanza MG, Lesca L, Peris C, Sismondi P. Androgenic progestogens oppose the decrease of insulin-like growth factor I serun level induced by conjugated oestrogens in postmenopausal women. Preliminary report. Maturitas. 1994;19:25–31
  13. Romagnoli E, Minisola S, Carnevale V, Scarda A, Rosso R, Scarnecchia L, et al. Circulating levels of insulin-like growth factor binding protein 3 (IGFBP-3) and insulin-like growth factor I (IGF-I) in perimenopausal women. Osteoporosis 1994;4:305–8.
  14. Bernardi F, Petraglia F, Seppala M, Spinetti A, Bertolini S, Ferdeghini M, et al.  Somatototropic axis and body weight in pre-menopausal and post-menopausal women (evidence for a neuroendocrine derangement, in absence of changes of insulin-like growth factor binding protein concentrations). Hum Reprod. 1998;13:279–284
  15. Neter J, Kutner MH, Nachtsheim CJ, Wasserman W. Applied linear statistical models. 4th ed.. Boston: Times Mirror Higher Education Group; 1996;
  16. Johnson RA, Wichern DW. Applied multivariate statistical analysis. 3rd ed.. New York: Prentice-Hall; 1992;
  17. Campagnoli C, Ambroggio S, Biglia N, Sismondi P. Conjugated estrogens and breast cancer risk. Gynecol Endocrinol. 1999;13(Suppl 6):13–19
  18. Murphy LJ, Friensen HG. Differential effects of estrogen and growth hormone on uterine and hepatic insulin-like growth factor I gene expression in the ovarioctomized hypophysectomized rat. Endocrinology. 1988;122:325–332
  19. Hasegawa T, Hasegawa Y, Takada M, Tsuchiya Y. The free form of insulin-like growth factor I increases in circulation during normal human pregnancy. J Clin Endocrinol Metab. 1995;80:3284–3286
  20. Barreca A, Ponzani P, Arvigo M, Voci A, Giordano G, Minuto F. Effect of the acid-labile subunit on the binding of insulin-like growth factor (IGF)-binding protein-3 to [125] IGF-I. J Clin Endocrinol Metab. 1995;80:1318–1324
  21. Le Roith D. Insulin-like growth factors. N Engl J Med. 1997;336:633–640
  22. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins (biological actions). Endocr Rev. 1995;16:3–34
  23. Aaronson SA. Growth factors and cancer. Science. 1991;254:1146–1157
  24. Blakesley VA, Stannard BS, Kalebic T, Helman LJ, Le Roth D. Role of the IGF-I receptor in mutagenesis and tumor promotion. J Endocrinol 1997;152:339–44.
  25. Stewart AJ, Johnson MD, May FE, Westley BR. Role of insulin-like growth factors and the type of insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells. J Biol Chem. 1990;265:2172–2178
  26. Byrne C, Colditz GA, Willett WC, Speizer FE, Pollak M, Hankinson SE. Plasma insulin-like growth factor (IGF) I, IGF-binding protein 3, and mammographic density. Cancer Res. 2000;60:3744–3748
  27. Gravholt CH, Naeraa RW, Fisker S, Christiansen JS. Body composition and physical fitness are major determinants of the growth hormone-insulin-like growth factor axis aberrations in adult Turner’s syndrome, with important modulations by treatment with 17β-estradiol. J Clin Endocrinol Metab. 1997;82:2570–2577
  28. Poiraudeau S, Roux C, Ceuninck DF, Tsagris L, Borderie D, Cherruau B, et al.  Circulating insulin-like growth factor system changes in women with acute estrogen deficiency induced by GnRH agonist. Osteoporos Int. 1997;7:463–469
  29. Suikkari A, Tiitinen A, Stenman U, Seppälä M, Laatikainen T. Oral contraceptives increase insulin-like growth factor binding protein-1 concentration in women with polycystic ovarian disease. Fertil Steril. 1991;55:895–899
  30. Katz LEL, Rosenfeld RG, Cohen P. Clinical significance of insulin-like growth factor binding proteins (IGFBPs). Endocrinologist. 1995;5:36–43
  31. Dimitriadis G, Parry BM, Bevan S, Dunger D, Piva T, Krause U, et al.  Effects of insulin-like growth factor I on the rates of glucose transport and utilization in rat skeletal muscle in vitro. Biochem J. 1992;285:269–274
  32. Rutanen E, Kärkkäinen T, Stenman UH, Yki-Järvinen H. Aging is associated with decreased suppression of insulin-like growth factorsbinding protein-1 by insulin. J Clin Endocrinol Metab. 1993;77:1152–1155
  33. Karam JH, Forshan PH. Pancreatic hormones and diabetes mellitus. In: Greenspan FS, Baxter JD. Basic and clinical endocrinology. 4th ed. London: Prentice-Hall International, 1994.
  34. Pfeifle B, Boeder H, Ditschuneit H. Interaction of receptors for insulin-like growth factor I, platelet-derived growth factor, and fibroblast growth factor in rat aortic cells. Endocrinology. 1987;120:2251–2258
  35. Cercek B, Fishbein MC, Forrester JS, Helfant RH, Fagin JA. Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudation. Circ Res. 1990;66:1755–1760

PII: S0015-0282(00)01691-5

Fertility and Sterility
Volume 75, Issue 2 , Pages 282-287 , February 2001

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