Fertility and Sterility
Volume 77, Issue 3 , Pages 499-504 , March 2002

Alternatively spliced variants of the follicle-stimulating hormone receptor gene in the testis of infertile men

Presented at the 56th Annual Meeting of the American Society for Reproductive Medicine, San Diego, California, October 21–26, 2000.

  • Gyun Jee Song, Ph.D.

      Affiliations

    • Corresponding Author InformationReprint requests: Gyun Jee Song, Ph.D., Samsung Cheil Hospital and Women’s Healthcare Center, 1-19 Mookjung-Dong, Chung-Ku, Seoul, 100-380 South Korea (FAX: 82-2-2265-5621)
    • Research Laboratory of Reproductive Biology and Infertility, Seoul, South Korea
    • Department of Biology, Seoul National University, Seoul, South Korea
    • ,
  • Yong-Seog Park, Ph.D.

      Affiliations

    • Research Laboratory of Reproductive Biology and Infertility, Seoul, South Korea
    • ,
  • You Sik Lee, M.D.

      Affiliations

    • Department of Urology, Seoul, South Korea
    • ,
  • Chung Choo Lee, Ph.D.

      Affiliations

    • Department of Biology, Seoul National University, Seoul, South Korea
    • ,
  • Inn Soo Kang, M.D

      Affiliations

    • Department of Obstetrics and Gynecology, Seoul, South Korea

Received 11 May 2001 ,Revised 20 September 2001 ,Accepted 20 September 2001.

References 

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  3. Namiki M, Koide T, Okuyama A, Sonoda T, Itatani H, Miyake A, et al.  Abnormality of testicular FSH receptors in infertile men. Acta Endocrinol. 1984;106:548–555
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  10. Themmen AP, Kraaij R, Grootegoed JA. Regulation of gonadotropin receptor gene expression. Mol Cell Endocrinol. 1994;100:15–19
  11. Kraaij R, Verhoef-Post M, Grootegoed JA, Themmen APN. Alternative splicing of follicle-stimulating hormone receptor pre-mRNA (cloning and characterization of two alternatively spliced mRNA transcripts). J Endocrinol. 1998;158:127–136
  12. Yaron Y, Schwartz D, Evans MI, Lessing JB, Rotter V. Alternatively spliced mRNA transcripts encoding the extracellular domain of the FSH receptor gene. J Reprod Med. 1998;42:435–438
  13. Sairam MR, Jiang LG, Khan H. Follitropin signal transduction (alternative splicing of the FSH receptor gene produces a dominant negative form of receptor which inhibits hormone action). Biochem Biophys Res Com. 1996;226:717–722
  14. Tena-Sempere M, Manna PR, Huhtaniemi I. Molecular cloning of the mouse follicle-stimulating hormone receptor complementary deoxyribonucleic acid (functional expression of altenatively exon 7 of the coding sequence). Bio Reprod. 1999;60:1515–1527
  15. O’Shaughnessy PJ, Dudley K, Rajapaksha WS. Expression of follicle stimulating hormone-receptor mRNA during gonadal. Mol Cell Endocrinol. 1996;125:169–175
  16. Tapanainen JS, Aottomake K, Kin J, Vaskiwuo T, Huhtaniemi IT. Men homozygous for an inactivating mutation of the FSH receptor gene present variable suppression of spermatogenesis and fertility. Nature Genet. 1997;15:205–206
  17. Simoni M, Gromoll J, Hoppner W, Kamischke A, Ktafft T, Stahle D, et al.  Mutational analysis of the follicle-stimulating hormone (FSH) receptor in normal and infertile men (identification and characterization of two discrete FSH receptor isoforms). J Clin Endocrinol Metab. 1999;84:751–756
  18. Tuerlings JHAM, Ligtenberg MJL, Kremer JAM, Sieres M, Meuleman EJH, Braat DDHM, et al.  Screening male intracytoplasmic sperm injection candidates for mutations of the follicle stimulating hormone receptor gene. Human Reprod. 1998;13:2098–2101
  19. Gromoll J, Gudermann T, Nieschlag E. Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor. Biochem Biophys Res Commun. 1992;199:1077–1083

PII: S0015-0282(01)03221-6

Fertility and Sterility
Volume 77, Issue 3 , Pages 499-504 , March 2002

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