Fertility and Sterility
Volume 77, Issue 4 , Pages 666-668 , April 2002

Insulin gene variable number of tandem repeats regulatory polymorphism is not associated with hyperandrogenism in Spanish women

  • Rosa M. Calvo, Ph.D.

      Affiliations

    • Department of Endocrinology, Hospital Ramón y Cajal, Madrid, Spain
  • ,
  • Dolores Tellerı́a, B.S.

      Affiliations

    • Department of Molecular Genetics, Hospital Ramón y Cajal, Madrid, Spain
  • ,
  • José Sancho, M.D., Ph.D.

      Affiliations

    • Department of Endocrinology, Hospital Ramón y Cajal, Madrid, Spain
  • ,
  • José L. San Millán, Ph.D.

      Affiliations

    • Department of Molecular Genetics, Hospital Ramón y Cajal, Madrid, Spain
  • ,
  • Héctor F. Escobar-Morreale, M.D., Ph.D.

      Affiliations

    • Corresponding Author InformationReprint requests: Héctor F. Escobar-Morreale, M.D., Ph.D., Hospital Ramón y Cajal, Servicio de Endocrinologı́a, Carretera de Colmenar Km 9.1, Madrid-28034, Spain (FAX: 34-91-3369016)
    • Department of Endocrinology, Hospital Ramón y Cajal, Madrid, Spain

Received 16 July 2001 ,Revised 28 September 2001 ,Accepted 28 September 2001.

References 

  1. Lucassen AM, Julier C, Beressi JP, Boitard C, Froguel P, Lathrop M, et al.  Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. Nat Genet. 1993;4:305–310
  2. Waterworth DM, Bennett ST, Gharani N, McCarthy MI, Hague S, Batty S, et al.  Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome. Lancet. 1997;349:986–990
  3. Urbanek M, Legro RS, Driscoll DA, Azziz R, Ehrmann DA, Norman RJ, et al.  Thirty-seven candidate genes for polycystic ovary syndrome (strongest evidence for linkage is with follistatin). Proc Natl Acad Sci USA. 1999;96:8573–8578
  4. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment (insulin resistance and β-cell function from fasting plasma insulin and glucose concentrations in man). Diabetologia. 1985;28:412–419
  5. Buchner A, Faul F, Erdfelder E. a priori, post-hoc, and compromise power analyses for the Macintosh (ver. 2.1.2). Trier, Germany: University of Trier; 1997;

 Supported by grants from the Consejerı́a de Educación y Cultura, Comunidad de Madrid, Spain (Proyectos 08.6/0022/1998 y 08.6/0024.2/2000) and from the Fondo de Investigación Sanitaria, Ministerio de Sanidad y Consumo, Spain (Proyecto FIS 00/0414 to H.F.E.-M. and Contrato FIS 98/3044 to R.M.C.).

PII: S0015-0282(01)03238-1

Fertility and Sterility
Volume 77, Issue 4 , Pages 666-668 , April 2002