Fertility and Sterility
Volume 78, Issue 5 , Pages 1073-1076 , November 2002

Effect of vaginal sildenafil on the outcome of in vitro fertilization (IVF) after multiple IVF failures attributed to poor endometrial development

  • Geoffrey Sher, M.D.

      Affiliations

    • Sher Institute for Reproductive Medicine, Las Vegas, Nevada, USA
    • Department of OB/GYN, University of Nevada, School of Medicine, Reno, Nevada, USA
    • Corresponding Author InformationReprint requests: Geoffrey Sher, M.D., 3121 S. Maryland Parkway, Suite 300, Las Vegas, Nevada 89109 USA (FAX: 702-892-9666)
    • ,
  • Jeffrey D Fisch, M.D.

      Affiliations

    • Sher Institute for Reproductive Medicine, Las Vegas, Nevada, USA

Received 6 November 2001 ,Revised 8 March 2002 ,Accepted 8 March 2002.

References 

  1. Ballard SA, Gingell CJ, Tang K, Turner LA, Price ME, Naylor AM. Effects of Sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isoenzymes. J Urol. 1998;159:2164–2171
  2. Telfer JF, Irvine GA, Kohnen G, Cambell S, Cameron IT. Expression of endothelial and inducible nitric oxide synthase in non-pregnant and decidualized human endometrium. Mol Hum Reprod. 1997;3:69–75
  3. Fisch JD, Behr B, Conti M. Enhancement of motility and acrosome reaction in human spermatozoa (differential activation by type-specific phosphodiesterase inhibitors). Hum Reprod. 1998;5:1248–1254
  4. Boolell M, Gepi-Attee S, Gingell JC, Allen MJ. Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br J Urol. 1996;78:257–261
  5. Sher G, Fisch JD. Vaginal sildenafil (Viagra) (a preliminary report of a novel method to improve uterine artery blood flow and endometrial development in patients undergoing IVF). Hum Reprod. 2000;15:806–809
  6. Gonen Y, Casper RF. Prediction of implantation by sonographic appearance during controlled ovarian stimulation for in vitro fertilization (IVF). J In Vitro Fert Embryo Transfer. 1990;7:146–152
  7. Sher G, Herbert C, Jacobs M, Maassarani G. Assessment of the late proliferative phase endometrium by ultrasonography in patients undergoing in vitro fertilization and embryo transfer (IVF-ET). Hum Reprod. 1991;6:232–237
  8. Sher G, Dodge S, Maassarani G, Knutzen V, Zouves C. Management of suboptimal sonographic endometrial patterns in patients undergoing in vitro fertilization and embryo transfer. Hum Reprod. 1993;8:374–379
  9. Weckstein LN, Jacobson A, Galen D, Hampton K, Hammel J. Low-dose aspirin for oocyte donation recipients with a thin endometrium (prospective, randomized study). Fertil Steril. 1997;68:927–930
  10. Cameron IT, Cambell S. Nitric oxide in the endometrium. Hum Reprod Update. 1998;4:565–569
  11. Amit A, Thaler I, Paz Y, Itskovitz-Eldor J. The effect of a nitric oxide donor on doppler flow velocity waveforms in the uterine artery during the first trimester of pregnancy. Ultrasound Obstet Gynecol. 1998;11:94–98

PII: S0015-0282(02)03375-7

Fertility and Sterility
Volume 78, Issue 5 , Pages 1073-1076 , November 2002

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