Fertility and Sterility
Volume 78, Issue 6 , Pages 1154-1158 , December 2002

Serum vascular endothelial growth factor levels are poorly predictive of subsequent ovarian hyperstimulation syndrome in highly responsive women undergoing assisted conception

  • Raj Mathur, M.D.

      Affiliations

    • Bristol University Centre for Reproductive Medicine.Bristol, United Kingdom
    • Corresponding Author InformationReprint requests: Raj Mathur, M.D., Reproductive Medicine Unit, Rosie Hospital, Cambridge, CB2 2SW, United Kingdom (FAX: 00-44-1223-215327).
    • ,
  • Grant Hayman, M.D.

      Affiliations

    • Department of Immunology, St. Helier’s Hospital., Carshalton, United Kingdom
    • ,
  • Amolak Bansal, M.D.

      Affiliations

    • Department of Immunology, St. Helier’s Hospital., Carshalton, United Kingdom
    • ,
  • Julian Jenkins, D.M.

      Affiliations

    • Bristol University Centre for Reproductive Medicine.Bristol, United Kingdom

Received 29 May 2002 ,Revised 5 July 2002 ,Accepted 5 July 2002.

References 

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  2. Mathur RS, Akande AV, Keay SD, Hunt LP, Jenkins JM. Distinction between early and late ovarian hyperstimulation syndrome. Fertil Steril. 2000;73:901–912
  3. Elchalal U, Schenker JG. The pathophysiology of ovarian hyperstimulation syndrome—views and ideas. Hum Reprod. 1997;12:1129–1137
  4. Goldsman MP, Pedram A, Dominguez CE, Ciuffardi I, Levin E, Asch RH. Increased capillary permeability induced by human follicular fluid (a hypothesis for an ovarian origin of the hyperstimulation syndrome). Fertil Steril. 1995;63:268–272
  5. Amato P, Zwain I, Yen SSC. Identification of vascular endothelial growth factor in human follicular fluid: a possible role in ovarian hyperstimulation syndrome. Proceedings of the 52nd Annual Meeting of the American Society of Reproductive Medicine; Birmingham, Alabama. Boston:1996
  6. McClure N, Healy DL, Rogers PA, Sullivan J, Beaton L, Haning RV, et al.  Vascular endothelial growth factor as capillary permeability agent in ovarian hyperstimulation syndrome. Lancet. 1994;344:235–236
  7. Neulen J, Yan Z, Raczek S, Weindel K, Keck C, Weich HA, et al.  Human chorionic gonadotropin-dependent expression of vascular endothelial growth factor/vascular permeability factor in human granulosa cells (importance in ovarian hyperstimulation syndrome). J Clin Endocrinol Metab. 1995;80:1967–1971
  8. Ferrara N, Houck K, Jakeman L, Leung DW. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev. 1992;13:18–32
  9. Brock TA, Dvorak H, Senger DR. Tumour secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells. Am J Pathol. 1991;138:213–221
  10. Abramov Y, Barak V, Nisman B, Schenker JG. Vascular endothelial growth factor plasma levels correlate to the clinical picture in severe ovarian hyperstimulation syndrome. Fertil Steril. 1997;67:261–265
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  12. Agrawal R, Sladkevicius P, Engmann L, Conway GS, Payne NN, Bekis J, et al.  Serum vascular endothelial growth factor and ovarian stromal blood flow are increased in women with polycystic ovaries. Hum Reprod. 1998;13:651–655
  13. Friedman CL, Seifer DB, Kennard EA, Arbogast L, Alak B, Danforth DR. Elevated level of follicular fluid vascular endothelial growth factor is a marker of diminished pregnancy potential. Fertil Steril. 2000;70:836–839
  14. Chen CD, Chen HF, Lu HF, Ho HN, Yang YS. Value of serum and follicular fluid cytokine profile in the prediction of moderate to severe ovarian hyperstimulation syndrome. Hum Reprod. 2000;15:1037–1042
  15. Polson DW, Adams J, Wadsworth J, Franks S. Polycystic ovaries (a common finding in normal women). Lancet. 1988;1:870–872
  16. Golan A, Ron-El R, Herman A, Soffer Y, Weinraub Z, Caspi E. Ovarian hyperstimulation syndrome (an update review). Obstet Gynecol Surv. 1989;44:430–441
  17. Artini PG, Fasciani A, Monti M, Luisi S, D’Ambrogio G, Gennaziani AR, et al.  Changes in serum vascular endothelial growth factor levels and the risk of ovarian hyperstimulation syndrome in women enrolled in an in vitro fertilization programme. Fertil Steril. 1998;70:560–564
  18. Ludwig M, Jelkman W, Bauer O, Diedrich K. Prediction of severe ovarian hyperstimulation syndrome by free serum vascular endothelial growth factor concentration on the day of human chorionic gonadotrophin administration. Hum Reprod. 1999;14:2437–2441
  19. Krasnow JS, Berga SL, Guzick DS, Zeleznik AJ, Yeo KT. Vascular permeability factor and vascular endothelial growth factor in ovarian hyperstimulation syndrome (a preliminary report). Fertil Steril. 1996;65:552–555
  20. Wolfgang J. Pitfalls in the measurement of circulating vascular endothelial growth factor. Clin Chem. 2001;47:617–623

PII: S0015-0282(02)04243-7

Fertility and Sterility
Volume 78, Issue 6 , Pages 1154-1158 , December 2002

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