Fertility and Sterility
Volume 78, Issue 6 , Pages 1149-1153 , December 2002

Role of acupuncture in the treatment of female infertility

  • Raymond Chang, M.D.

      Affiliations

    • The Institute of East-West Medicine, New York, New York, USA
    • The Department of Internal Medicine, Weill Medical College of Cornell University, New York, New York, USA
  • ,
  • Pak H Chung, M.D.

      Affiliations

    • The Department of Internal Medicine, Weill Medical College of Cornell University, New York, New York, USA
    • Corresponding Author InformationReprint requests: Pak H. Chung, M.D., The Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, 505 East 70 Street, New York, New York, USA 10021 (FAX: 212-746-8208; E-mail:
  • ,
  • Zev Rosenwaks, M.D.

      Affiliations

    • The Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York, USA

Received 24 June 2002 ,Revised 19 July 2002 ,Accepted 19 July 2002.

References 

  1. NIH Consensus Development Panel of Acupuncture . Acupuncture. JAMA. 1998;280:1518–1524
  2. Dundee JW, Ghaly RG, Lynch GA, Fitzpatrick KT, Abram WP. Acupuncture prophylaxis of cancer chemotherapy-induced sickness. J R Soc Med. 1989;82:268–271
  3. Christiansen PA, Noreng M, Andersen PE, Nielsen JW. Electroacupuncture and postoperative pain. Br J Anaesth. 1989;62:258–262
  4. Martelete M, Fiori AMC. Comparative study of analgesic effect of transcutaneous nerve stimulation (TNS), electroacupuncture (EA), and meperidine in the treatment of postoperative pain. Acupunct Electrother Res. 1985;10:183–193
  5. Lao L, Bergman S, Langenberg P, Wong RH, Berman B. Efficacy of Chinese acupuncture on postoperative oral surgery pain. Oral Surg Med Oral Path Oral Radiol Endod. 1995;79:423–428
  6. Bullock ML, Culliton PD, Olander RT. Controlled trial of acupuncture for severe recidivist alcoholism. Lancet. 1989;1:1435–1439
  7. Clavel-Chapelon F, Paoletti C, Banhamou S. Smoking cessation rates 4 years after treatment by nicotine gum and acupuncture. Prev Med. 1997;26:25–28
  8. He D, Berg JE, Hostmark AT. Effects of acupuncture on smoking cessation or reduction for motivated smokers. Pev Med. 1997;26:208–214
  9. Margolin A, Avants SK, Chang P, Kosten TR. Acupuncture for the treatment of cocaine dependence in methadone-maintained patients. Am J Addict. 1993;2:194–201
  10. Patel M, Gutzwiller F, Paccaud F, Marazzi A. A meta-analysis of acupuncture for chronic pain. Int J Epidemiol. 1989;18:900–906
  11. Shlay JC, Chaloner K, Max MB, Flaws B, Reichelderfer P, Wentworth D, et al.  Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy: a randomized control trial. JAMA. 1998;280:1590–1595
  12. Tier Riet G, Kleijnen J, Knipschild P. Acupuncture and chronic pain (a criteria based meta-analysis). J Clin Epidemiol. 1990;43:1191–1199
  13. Chez RA, Jonas WB. Complementary and alternative medicine. Part II (Clinical studies in gynecology). Obstet Gynecol Surv. 1997;52:709–716
  14. Wu XJ, Cui YL, Yang BY, Zhou QM. Observations on the effect of He-Ne laser acupoint radiation in chronic pelvic inflammation. J Tradit Chin Med. 1987;7:263–265
  15. Beal MW. Acupuncture and acupressure. Applications to women’s reproductive health care. J Nurse Midwifery. 1999;44:217–230
  16. Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, et al.  Trends in alternative medicine use in the United States, 1990–1997 (results of a follow-up national survey). JAMA. 1998;280:1569–1575
  17. World Health Organization . A proposed standard international acupuncture nomenclature: report of a WHO scientific group. Geneva, Switzerland: World Health Organization; 1991;
  18. McCaig CD. Sinal neurite reabsorption and regrowth in vitro depend on the polarity of an applied electric field. Development. 1987;100:31–41
  19. Mayer DJ, Price DD, Rafil A. Antagonism of acupuncture analgesia in man by the narcotic antagonist naloxone. Brain Res. 1977;121:368–372
  20. Petti F, Bangrazi A, Liguori A, Reale G, Ippoliti F. Effects of acupuncture on immune response related to opioid-like peptides. J Tradit Chin Med. 1998;18:55–63
  21. Ulett GA, Han S, Han JS. Electroacupuncture (mechanisms and clinical application). Biol Psychiatry. 1998;44:129–138
  22. Ku Y, Chang Y. Beta-endorphin and GABA-mediated depressor effect of specific electroacupuncture surpasses pressor response of emotional circuit. Peptides. 2001;22:1465–1470
  23. Facchinetti F, Storchi AR, Petraglia F, Volpe A, Genazzani AR. Expression of proopiomelanocortin-related eptides in human follicular fluid. Peptides. 1988;9:1089–1092
  24. Gallinelli A, Garuti G, Matteo ML, Genazzani AR, Facchinetti F. Expression of proopiomelanocortin gene in human ovarian tissue. Hum Reprod. 1995;10:1085–1089
  25. DeBold CD, Menefee JK, Nicholson WE, Orth DN. Proopiomelanocortin gene is expressed in many normal human tissues and intumors not associated with ectopic adrenocorticotropin syndrome. Mol Endocrinol. 1988;2:862–870
  26. Aleem FA, Eltabbakh GH, Omar RA, Couthren AL. Ovarian follicular fluid beta-endorphin levels in normal and polycystic ovaries. Am J Obstet Gynecol. 1987;156:1197–1200
  27. Aleem FA, Omar RA, Eltabbakh GH. Immunoreative beta-endorphin in human ovaries. Fertil Steril. 1986;45:507–511
  28. Ferin M, Van de Wiele RL. Endogenous opioid peptides and the control of the menstrual cycle. Eur J Obstet Gynecol Repro Biol. 1984;10:365–373
  29. Quigley ME, Sheeham KL, Casper RF, Yen SSC. Evidence for an increased opioid inhibition of luteinizing hormone secretion in hyperprolactinemic patients with pituitary microadenoma. J Clin Endocrinol Metabol. 1980;50:427–446
  30. Ching M. Morphine suppresses the proestrous surge of GnRH in pituitary portal plasma of rats. Endocrinology. 1983;112:2209–2211
  31. Orstead KM, Spics HG. Inhibition of hypothalamic gonadotropin releasing hormone release by endogenous opioid peptides in the female rabbit. Neuroendocrinology. 1987;46:14–23
  32. Kalra SP, Horvath T, Naftolin F, Xu B, Pu S, Kalra PS. The interactive language of the hypothalamus for the gonadotropin releasing hormone (GNRH) system. J Neuroendocrinol. 1997;9:569–576
  33. Pau KY, Spies HG. Neuroendocrine signals in the regulation of gonadotropin-releasing hormone secretion. Chin J Physiol. 1997;40:181–196
  34. Rossmanith WG, Mortola JF, Yen SSC. Role of endogenous opioid peptides in the initiation of the mid-cycle luteinizing hormone surge in normal cycling women. J Clin Endocrinol Metab. 1988;67:695–700
  35. Petraglia F, DiMeo G, Storchi R, Segre A, Facchinette F, Szalay S, et al.  Proopiomelanocortin-related peptides and methionine enkephalin in human follicular fluid (changes during the menstrual cycle). Am J Obstet Gynecol. 1987;157:142–146
  36. Lin JH, Liu SH, Chan WW, Wu LS, Pi WP. Effects of electroacupuncture and gonadotropin-releasing hormone treatments on hormone changes in anoestrous sows. Am J Chin Med. 1988;16:117–126
  37. Yang SP, Yu J, He L. Release of gonadotropin-releasing hormone (GnRH) from the medio-basal hypothalamus induced by electroacupuncture in conscious female rabbits. Acupunct Electrother Res. 1994;19:19–27
  38. Aso T, Motohashi T, Murata M, Nishimura T, Kakizaki K. The influence of acupuncture stimulation on plasma levels of LH, FSH, progesterone and estradiol in normally ovulating women. Am J Chin Med. 1976;4:391–401
  39. Yu J, Zheng HM, Ping SM. Changes in serum FSH, LH and ovarian follicular growth during electroacupuncture for induction of ovulation. [Chinese] Chung Hsi I Chieh Ho Tsa Chih. 1989;9:199–202
  40. Mo X, Li D, Pu Y, Xi G, Le X, Fu Z. Clinical studies on the mechanism of acupuncture stimulation of ovulation. J Trad Chin Med. 1993;13:115–119
  41. Cai X. Substitution of acupuncture for human chorionic gonadotropin in ovulation induction. J Tradit Chin Med. 1997;17:119–121
  42. Chen BY, Yu J. Relationship between blood radioimmunoreactive beta-endorphin and hand skin temperature during the electro-acupuncture induction of ovulation. Acupunct Electrother Res. 1991;16:1–5
  43. Chen BY. Acupuncture normalizes dysfunction of hypothalamic-pituitary-ovarian axis. Acupunct Electrother Res. 1997;22:97–108
  44. Gerhard I, Postneek F. Auricular acupuncture in the treatment of female infertility. Gynecol Endocrinol. 1992;6:171–181
  45. Stener-Victorin E, Waldenstrom U, Tagnfors U, Lundeberg T, Lundstedt G, Janson PO. Effects of electro-acupuncture on anovulation in women with polycystic ovary syndrome. Acta Obstet Gynecol Scand. 2000;79:180–188
  46. Paulus WE, Zhang M, Strehler E, El-Danasouri I, Sterzik K. Influence of acupuncture on the pregnancy rate in patients who undergo assisted reproduction therapy. Fert Steril. 2002;77:721–724
  47. Haker E, Egekvist H, Bjerring P. Effect of sensory stimulation (acupuncture) on sympathetic and parasympathetic activities in healthy subjects. J Automomic Nerv Sys. 2000;79:52–59
  48. Yao T, Andersson S, Thoren P. Long-lasting cardiovascular depression induced by acupuncture-like stimulation of the sciatic nerve in unanaesthetized spontaneously hypertensive rats. Brain Res. 1982;240:77–85
  49. Knardahl S, Elam M, Olausson B, Wallin BG. Sympathetic nerve activity after acupuncture in humans. Pain. 1998;75:19–25
  50. Noyes N, Liu HC, Sultan K, Schattman G, Rosenwaks Z. Endometrial thickness appears to be a significant factor in embryo implantation in in-vitro fertilization. Hum Reprod. 1995;10:919–922
  51. Schild RL, Knoblock C, Dorn C, Fimmers R, van der Ven H, Hansmann M. Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood flow, endometrial thickness, endometrial volume, and uterine artery blood flow. Fertil Steril. 2001;75:361–366
  52. Chiang CH, Hsieh TT, Chang MY, Shiau CS, Hou HC, Hsu JJ, et al.  Prediction of pregnancy rate of in vitro fertilization and embryo transfer in women aged 40 and over with basal uterine artery pulsatility index. J Assist Reprod Genet. 2000;17:409–414
  53. Engmann L, Sladkevicius P, Agrawal R, Bekir J, Campbell S, Tan SL. The pattern of changes in ovarian stromal and uterine artery blood flow velocities during in vitro fertilization treatment and its relationship with outcome of the cycle. Ultrasound Obstet Gynecol. 1999;13:26–33
  54. Salle B, Bied-Damon V, Benchaib M, Desperes S, Gaucherand P, Rudigoz RC. Preliminary report of an ultrasonography and colour Doppler uterine score to predict uterine receptivity in an in-vitro fertilization programme. Hum Reprod. 1998;13:1669–1673
  55. Aytoz A, Ubaldi F, Tournaye H, Nagy ZP, Van Steirteghem A, Devroey P. The predictive value of uterine artery blood flow measurements for uterine receptivity in an intracytoplasmic sperm injection program. Fertil Steril. 1997;68:935–937
  56. Friedler S, Schenker JG, Herman A, Lewin A. The role of ultrasonography in the evaluation of endometrial receptivity following assisted reproductive treatments (a critical review). Hum Reprod Update. 1996;2:323–335
  57. Zaidi J, Pittrof R, Shaker A, Kyei-Mensah A, Campbell S, Tan SL. Assessment of uterine artery blood flow on the day of human chorionic gonadotropin administration by transvaginal color Doppler ultrasound in an in vitro fertilization program. Fertil Steril. 1996;65:377–381
  58. Sher G, Fisch JD. Vaginal sildenifil (Viagra) (a preliminary report of a novel method to improve uterine artery blood flow and endometrial development in patients undergoing IVF). Hum Reprod. 2000;15:806–809
  59. Stener-Victorin E, Waldenstrom U, Andersson SA, Wikland M. Reduction of blood flow impedance in the uterine arteries of infertile women with electro-acupuncture. Hum Reprod. 1996;11:1314–1317
  60. Schenker JG, Meirow D, Schenker E. Stress and human reproduction. Eur J Obstet Gynecol Reprod Biol. 1992;45:1–8
  61. Eugster A, Vingerhoets AJ. Psychological aspects of in vitro fertilization (a review). Soc Sci Med. 1999;48:575–589
  62. Domar AD, Broome A, Zuttermeister PC, Seibel M, Friedman R. The prevalence and predictability of depression in infertile women. Fertil Steril. 1992;58:1158–1163
  63. Domar AD, Zuttermeister PC, Friedman R. The psychological impact of infertility (a comparison with patients with other medical conditions). J Psychosom Obstet Gynaecol. 1993;14:45–52
  64. Mahlstedt PP, Macduff S, Bernstein J. Emotional factors in in vitro fertilization and embryo transfer process. J In Vitro Fert Embryo Transf. 1987;4:232–235
  65. Seibel MM, Taymor ML. Emotional aspects of infertility. Fertil Steril. 1982;37:137–145
  66. Domar AS, Seibel MM, Benson H. The mind/body program for infertility (a new behavioral treatment approach for women with infertility). Fertil Steril. 1990;53:246–249
  67. Chen A. An introduction to sequential electric acupuncture (SEA) in the treatment of stress related physical and mental disorders. Acupunct Electrother Res. 1992;17:273–283
  68. Dong JT. Research on the reduction of anxiety and depression with acupuncture. Am J Acupunct. 1993;21:327–330
  69. Luo H, Meng F, Jia Y, Zhao X. Clinical research on the therapeutic effect of the electroacupuncture treatment in patients with depression. Psychiatry Clin Neurosci. 1998;52:S338–340

PII: S0015-0282(02)04348-0

Fertility and Sterility
Volume 78, Issue 6 , Pages 1149-1153 , December 2002