Fertility and Sterility
Volume 79, Issue 3 , Pages 577-584 , March 2003

Conception, early pregnancy loss, and time to clinical pregnancy: a population-based prospective study

  • Xiaobin Wang, M.D.

      Affiliations

    • Department of Pediatrics, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, USA
    • ,
  • Changzhong Chen, M.D.

      Affiliations

    • Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    • ,
  • Lihua Wang, M.D.

      Affiliations

    • Center for Ecogenetics and Reproductive Health, Beijing Medical University, Beijing Medical University, Beijing, China
    • ,
  • Dafang Chen, M.D.

      Affiliations

    • Center for Ecogenetics and Reproductive Health, Beijing Medical University, Beijing Medical University, Beijing, China
    • Institute for Biomedicine, Anhui Medical University, Anhui, China
    • ,
  • Wenwei Guang, M.D.

      Affiliations

    • Institute for Biomedicine, Anhui Medical University, Anhui, China
    • ,
  • Jonathan French, PhD.

      Affiliations

    • Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
    • ,
  • The Reproductive Health Study Group

      Affiliations

    • The Reproductive Health Study Group also includes Sung-Il Cho, M.D., Aiqun Huang, M.D., Louise Ryan, Ph.D., John O’Connor, Ph.D., Bill Lasley, Ph.D., James W. Overstreet, M.D., David C. Christiani, M.D., Allen Wilcox, M.D., and Xiping Xu, M.D.
    • Corresponding Author InformationReprint requests: Xiping Xu, M.D., Ph.D., Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, FXB 1, Boston, Massachusetts 02115, USA (FAX: 617-414-3679).
    • Corresponding Author InformationReprint requests: Xiping Xu, M.D., Ph.D., Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, FXB 1, Boston, Massachusetts 02115, USA (FAX: 617-414-3679).
    • xbwang@bu.edu

Received 2 April 2002 ,Revised 13 August 2002 ,Accepted 13 August 2002.

References 

  1. Modvig J, Schmidt L, Damsgaard MT. Measurement of total risk of spontaneous abortion (the virtue of conditional risk estimation). Am J Epidemiol. 1990;132:1021–1038
  2. Wilcox AJ. Surveillance of pregnancy loss in human populations. Am J Ind Med. 1983;4:285–291
  3. Wilcox AJ, Weinberg CR, Wehmann RE, Armstrong EG, Canfield RE, Nisula BC. Measuring early pregnancy loss (laboratory and field methods). Fertil Steril. 1985;44:366–374
  4. Wilcox AJ, Weinberg CR, O’Connor JF, Baird DD, Schlatterer JP, Canfield RE, et al.  Incidence of early loss of pregnancy. N Engl J Med. 1988;319:189–194
  5. Zinaman MJ, O’Connor J, Clegg ED, Selevan SG, Brown CC. Estimates of human fertility and pregnancy loss. Fertil Steril. 1996;65:503–509
  6. Baird DD, Wilcox AJ, Weinberg CR. Use of time to pregnancy to study environmental exposures. Am J Epidemiol. 1986;124:470–480
  7. Gelman A, Carlin JB, Stern HS, Rubin DB. Bayesian data analysis. London: Chapman and Hall; 1997;
  8. Dunson DB. A Bayesian model for fecundability and sterility. J Am Stat Assoc. 2000;95:1054–1062
  9. O’Connor JF, Schlatterer JP, Birken S, Krichevsky A, Armstrong EG, McMahon D, et al.  Development of highly sensitive immunoassays to measure human chorionic gonadotropin, its beta subunit and beta core fragment in the urine (application to malignancies). Can Res. 1988;48:1361–1366
  10. Husdan H, Rapoport A. Estimation of creatinine by the Jaffe reaction. A comparison of three methods. Clin Chem. 1968;14:222–238
  11. Liang K-Y, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrica. 1986;73:13–22
  12. Monson RR. Occupational epidemiology. Boca Raton, FL: CRC Press; 1990;

☆ Supported in part by grants 1R01 HD32505 from the National Institute of Child Health and Human Development, Bethesda, Maryland; grants 1R01 ES08337, ES-00002, P01 ES06198, and 1R01 ES11682 from the National Institute of Environmental Health Science, Research Triangle, North Carolina; and grants 20-FY98-0701 and 20-FY02-56 from the March of Dimes Birth Defects Foundation, White Plains, New York.

PII: S0015-0282(02)04694-0

doi: 10.1016/S0015-0282(02)04694-0

Fertility and Sterility
Volume 79, Issue 3 , Pages 577-584 , March 2003

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