Fertility and Sterility
Volume 79, Issue 3 , Pages 543-549 , March 2003

Cytologic aspects of the nasal respiratory epithelium in postmenopausal women treated with hormone therapy

  • Salvatore Caruso, M.D.

      Affiliations

    • Research Group for Sexology, Department of Microbiological Science and Gynecological Science, School of Medicine University of Catania, Catania, Italy
    • Corresponding Author InformationReprint requests: Salvatore Caruso, M.D., Ospedale S. Bambino, Via Torre del Vescovo, 95124 Catania, Italy (FAX: 39-095-312001).
  • ,
  • Lucia Roccasalva, M.D.

      Affiliations

    • Menopausal Service, Department of Microbiological Science and Gynecological Science, School of Medicine, University of Catania, Catania, Italy
  • ,
  • Enza Di Fazio, M.D.

      Affiliations

    • Department of Otorhinolaryngology, School of Medicine, University of Catania, Catania, Italy
  • ,
  • Gloria Sapienza, M.D.

      Affiliations

    • Research Group for Sexology, Department of Microbiological Science and Gynecological Science, School of Medicine University of Catania, Catania, Italy
  • ,
  • Carmela Agnello, M.D.

      Affiliations

    • Research Group for Sexology, Department of Microbiological Science and Gynecological Science, School of Medicine University of Catania, Catania, Italy
  • ,
  • Simona Ficarra, M.D.

      Affiliations

    • Department of Otorhinolaryngology, School of Medicine, University of Catania, Catania, Italy
  • ,
  • Lucia Di Mari, M.D.

      Affiliations

    • Research Group for Sexology, Department of Microbiological Science and Gynecological Science, School of Medicine University of Catania, Catania, Italy
  • ,
  • Agostino Serra, M.D.

      Affiliations

    • Department of Otorhinolaryngology, School of Medicine, University of Catania, Catania, Italy

Received 21 March 2002 ,Revised 17 September 2002 ,Accepted 17 September 2002.

References 

  1. Sherman BM, West JH, Korenman SG. The menopausal transition (analysis of LH, FSH, estradiol and progesterone concentrations during menstrual cycle of older women). J Clin Endocrinol Metab. 1974;42:629–636
  2. Pennington GW, Naik S. Hormone analysis (methodology and clinical interpretation). Key Biscayne (FL): CRS Press; 1980;
  3. Hammond CB. Menopause and hormone replacement therapy (an overview). Obstet Gynecol. 1996;87:2S–15S
  4. Wiklund I, Berg G, Hammar M, Karlberg J, Lindgren R, Sandin K. Long-term effect of transdermal hormone therapy on aspects of quality of life in postmenopausal women. Maturitas. 1992;14:225–236
  5. Lichtman R. Perimenopausal and postmenopausal hormone replacement therapy. J Nurse Midwifery. 1996;41:3–28
  6. Burger HG. The endocrinology of the menopause. J Steroid Biochem Mol Biol. 1999;69:31–35
  7. Brittebo EB. Localization of oestradiol in the rat nasal mucosa. Acta Pharmacol Toxicol. 1985;57:285–290
  8. Helmi AM, El Ghazzawi IF, Mandour MA, Shehata MA. The effect of oestrogen on the nasal respiratory mucosa. An experimental histopathological and histochemical study. J Laryngol Otol. 1975;89:1229–1241
  9. Zhao X, Dong Z, Yang Z. An experimental observation on the influence of the different levels of estradiol on the nasal mucosa. Zhonghua Er Bi Yan Hou Ke Za Zhi. 1994;29:98–100
  10. Grillo C, La Mantia I, Triolo C, Scollo A, Intelisano G, Caruso S. Rhinomanometric and olfactometric variations throughout the menstrual cycle. Ann Otol Rhinol Laryngol. 2001;110:785–789
  11. Farbman A. The biology of olfaction. Cambridge (UK): Cambridge University Press; 1992;
  12. Ship A, Pearson JD, Criuse LJ, Brant LJ, Matter EJ. Longitudinal changes in smell identification. J Gerontol. 1996;51:M86–M91
  13. Doty RL. A review of olfactory dysfunction in man. Am J Otolaryngol. 1979;1:57–79
  14. Naessen R. An enquiry of the morphological characteristics and possible changes with age in the olfactory region of man. Acta Otolaryngol. 1971;71:49–62
  15. Rosli Y, Breckenridge LJ, Smith A. An ultrastructural study of age-related changes in mouse olfactory epithelium. J Electron Microsc (Tokyo). 1999;48:77–84
  16. Nakashima T, Kimmelman CP, Snow JB. Structure of human fetal and adult olfactory neuroepithelium. Arch Otolaryngol. 1984;110:641–646
  17. van der Laak JA, Schijf CP, Kerstens HM, Heijnen-Wijnen TH, de Wilde PC, Hanselaar GJ. Development and validation of a computerized cytomorphometric method to assess the maturation of vaginal epithelial cells. Cytometry. 1999;35:196–202
  18. World Health Organization . Research on the menopause in the 1990s. Report of a WHO scientific group. WHO Technical Report series no. 866. Geneva: World Health Organization; 1996;
  19. Don’at J. The postmenopausal estrogen deficiency syndrome and hormone replacement therapy. Cas Lek Cesk. 1997;136:343–347
  20. Velle W. Sex differences in sensory functions. Perspect Biol Med. 1987;30:491–523
  21. Caruso S, Roccasalva L, Sapienza G, Zappalá M, Nuciforo G, Biondi S. Laryngeal cytological aspects in women with surgically induced menopause who were treated with transdermal estrogen replacement therapy. Fertil Steril. 2000;74:1073–1079
  22. Caruso S, Cianci A, Grasso D, Agnello C, Galvani F, Maiolino L, et al.  Auditory brainstem response in postmenopausal women treated with hormone replacement therapy (a pilot study). Menopause. 2000;7:178–183
  23. Toppozada H. The human nasal mucosa in the menopause (a histochemical and electron microscopic study). J Laryngol Otol. 1988;102:314–318
  24. Haeggstrom A, Ostberg B, Stjerna P, Graf P, Hallen H. Nasal mucosal swelling and reactivity during a menstrual cycle. ORL J Othorhinolaryngol Relat Spec. 2000;62:39–42
  25. Caruso S, Grillo C, Agnello C, Maiolino L, Intelisano G, Serra A. A prospective study evidencing rhinomanometric and olfactometric outcomes in women taking oral contraceptives. Hum Reprod. 2001;16:2288–2294

PII: S0015-0282(02)04844-6

doi: 10.1016/S0015-0282(02)04844-6

Fertility and Sterility
Volume 79, Issue 3 , Pages 543-549 , March 2003