Fertility and Sterility
Volume 80, Issue 3 , Pages 595-599 , September 2003

Comparison of the effectiveness of single intrauterine insemination (IUI) versus double IUI per cycle in infertile patients

  • Saeed Alborzi, M.D.

      Affiliations

    • Division of Infertility and Endoscopy, Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
    • Corresponding Author InformationReprint requests: Saeed Alborzi, M.D., P.O. Box 71345-1818, Shiraz, Iran (FAX: 98-711-6253291).
  • ,
  • Shahdokht Motazedian, M.D.

      Affiliations

    • Division of Infertility and Endoscopy, Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
  • ,
  • Mohammad E Parsanezhad, M.D.

      Affiliations

    • Division of Infertility and Endoscopy, Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
  • ,
  • Sima Jannati, M.D.

      Affiliations

    • Division of Infertility and Endoscopy, Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran

Received 11 July 2002 ,Revised 21 February 2003 ,Accepted 21 February 2003.

References 

  1. Silverberg KM, Johnson JV, Olive DL, Burns W, Schenken RS. A prospective, randomized trial comparing two different intrauterine insemination regimens in controlled ovarian hyperstimulation cycles. Fertil Steril. 1992;57:357–361
  2. Ransom MX, Blotner MB, Bohrer M, Corsan G, Kemmann E. Does increasing frequency of intrauterine insemination improve pregnancy rates significantly during superovulation cycles?. Fertil Steril. 1994;61:303–307
  3. Ragni G, Maggioni P, Guermandi E, Testa A, Baroni E, Colombo M, et al.  Efficacy of double intrauterine insemination in controlled ovarian hyperstimulation cycles. Fertil Steril. 1999;72:619–622
  4. Collection and examination of human semen. In: WHO laboratory manual for the examination of human semen and semen-cervical mucus interaction. Fourth edition. Cambridge (UK): Cambridge University Press, 1999:4–5.
  5. Dickey RP, Pyrzak R, Lu PY, Taylor SN, Rye PH. Comparison of the sperm quality necessary for successful intrauterine insemination with World Health Organization threshold values for normal sperm. Fertil Steril. 1999;71:684–689
  6. Stone BA, Vargyas JM, Ringler GE, Stein AL, Marrs RP. Determinants of the outcome of intrauterine insemination (analysis of outcomes of 9963 consecutive cycles). Am J Obstet Gynecol. 1999;180:1522–1534
  7. Berg U, Bruker C, Berg FD. Effect of motile sperm count after swim-up on outcome of intrauterine insemination. Fertil Steril. 1997;67:747–750
  8. Zreik TG, Garcia-Velasco JA, Habboosh MS, Olive DL, Arici A. Prospective, randomized, cross over study to evaluate the benefit of HCG-timed versus urinary luteinizing hormone-timed IUI in clomiphene citrate stimulated treatment cycles. Fertil Steril. 1999;71:1070–1074
  9. Dodson WC, Haney AF. Controlled ovarian hyperstimulation and intrauterine insemination for treatment of infertility. Fertil Steril. 1991;55:457–467
  10. van der Westernlaken LA, Naaktgeboren N, Helmerhost FM. Evaluation of pregnancy rates after intrauterine insemination according to indication, age, and sperm parameters. J Assist Reprod Genet. 1998;15:359–364
  11. Kirby CA, Warnes GM, Flaherty SP, Matthews CD, Godfrey BM. A prospective trial of intrauterine insemination of motile spermatozoa versus timed intercourse. Fertil Steril. 1991;56:102–107
  12. Agarwal SK, Buyalos RP. Clomiphene citrate with intrauterine insemination (is it effective therapy in women above the age of 35 years?). Fertil Steril. 1996;65:759–763
  13. Van Voorhis BJ, Barnett M, Sparks AE, Syrop CH, Rosenthal G, Daveson J. Effect of the total motile sperm count on the efficacy and cost effectiveness of intrauterine insemination and in vitro fertilization. Fertil Steril. 2001;75:661–668
  14. Guzick DS, Carson SA, Coutifaris C, Overstreet JW, Factor-Litvak P, Steinkampf MP, et al.  Efficacy of ovulation and intrauterine insemination in the treatment of infertility. N Engl J Med. 1999;340:177–183
  15. Melis GB, Paoletti AM, Strigini F, Fabris FM, Canale D, Fioretti P. Pharmacologic induction of multiple follicular development improves the success rate of artificial insemination with husband's semen in couples with male related or unexplained infertility. Fertil Steril. 1987;47:441–445
  16. Martinez AR, Bernardus RE, Voorhorst FJ, Vermeiden JP, Schoemaker J. Intrauterine insemination does and clomiphene citrate does not improve fecundity in couples with infertility due to male or idiopathic factors (a prospective, randomized, controlled study). Fertil Steril. 1990;53:847–853
  17. Khalil MR, Rasmussen PE, Erb K, Laursen SB. Homologous intrauterine insemination. An evaluation of prognostic factors based on a review of 2473 cycles. Acta Obstet Gynecol Scand. 2001;80:74–81
  18. Gerli S, Gholami H, Manna A, Di Frega AS, Vitiello C, Unfer V. Use of ethinyl estradiol to reverse the antiestrogenic effects of clomiphene citrate in patients undergoing intrauterine insemination (a comparative, randomized study). Fertil Steril. 2000;73:85–89

PII: S0015-0282(03)00980-4

doi: 10.1016/S0015-0282(03)00980-4

Fertility and Sterility
Volume 80, Issue 3 , Pages 595-599 , September 2003