Fertility and Sterility
Volume 80, Issue 6 , Pages 1413-1419 , December 2003

Pregnancy rates are higher with intracytoplasmic morphologically selected sperm injection than with conventional intracytoplasmic injection

  • Benjamin Bartoov, Ph.D.

      Affiliations

    • Male Fertility Laboratory, Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel
    • Corresponding Author InformationReprints requests: Prof. Benjamin Bartoov, Male Fertility Laboratory, Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 52900, Israel (FAX: 972-3-5343679).
    • ,
  • Arie Berkovitz, M.D.

      Affiliations

    • IVF Unit, Department of Obstetrics and Gynaecology, Sapir Medical Center, Meir Hospital, Kfar Saba, Israel
    • ,
  • Fina Eltes, M.Sc.

      Affiliations

    • Male Fertility Laboratory, Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel
    • ,
  • Avraham Kogosovsky, M.D.

      Affiliations

    • IVF Unit, Herzliya Medical Center, Herzliya-on-the-Sea, Israel
    • ,
  • Arie Yagoda, M.D.

      Affiliations

    • Women's Health Centre, Kupat Holim Leumit, Israel
    • ,
  • Hanna Lederman, M.Sc.

      Affiliations

    • Male Fertility Laboratory, Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel
    • ,
  • Shira Artzi, M.Sc.

      Affiliations

    • IVF Unit, Herzliya Medical Center, Herzliya-on-the-Sea, Israel
    • ,
  • Moshe Gross, M.D.

      Affiliations

    • Women's Health Centre, Kupat Holim Leumit, Israel
    • ,
  • Yona Barak, Ph.D.

      Affiliations

    • IVF Unit, Herzliya Medical Center, Herzliya-on-the-Sea, Israel

Received 12 December 2002 ,Revised 1 May 2003 ,Accepted 1 May 2003.

References 

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  2. Ola B, Afnan M, Sharif K, Papaioannou S, Hammadieh N, Barratt CL. Should ICSI be the treatment of choice for all cases of in-vitro conception? Considerations of fertilization and embryo development, cost effectiveness and safety. Hum Reprod. 2001;6:2485–2490
  3. Kuczynski W, Dhont M, Grygoruk C, Grochowski D, Wolczynski S, Szamatowicz M. The outcome of intracytoplasmic injection of fresh and cryopreserved ejaculated spermatozoa—a prospective randomized study. Reprod. 2001;16:2109–2113
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  5. Olivius K, Friden B, Lundin K, Bergh C. Cumulative probability of live birth after three in vitro fertilization/intracytoplasmic sperm injection cycles. Fertil Steril. 2002;77:505–510
  6. Stolwijk AM, Wetzels AM, Braat DD. Cumulative probability of achieving an ongoing pregnancy after in-vitro fertilization and intracytoplasmic sperm injection according to a woman's age, subfertility diagnosis and primary or secondary subfertility. Hum Reprod. 2000;15:203–209
  7. Oehninger S. Strategies for the infertile man. Semin Reprod Med. 2001;19:231–237
  8. Hardy K, Wright C, Rice S, Tachataki M, Roberts R, Morgan D, et al.  Future developments in assisted reproduction in humans. Reproduction. 2000;2:171–183
  9. Bartoov B, Berkovitz A, Eltes F, Kogosowski A, Menezo Y, Barak Y. Relationship between human sperm subtle morphological characteristics and IVF-ICSI outcome. J Androl. 2002;23:1–8
  10. World Health Organization (WHO) . Laboratory manual for the examination of human semen and semen–cervical mucus interaction. 4th ed. Cambridge, UK: Cambridge University Press; 1999;
  11. Glezerman M, Bartoov B. Semen analysis. In:  Insler V,  Lunenfeld B editor. Infertility: male and female. Edinburgh, London: Churchill Livingstone; 1993;p. 285–315
  12. Bartoov B, Eltes F, Pansky M, Langzam J, Reichart M, Soffer Y. Improved diagnosis of male fertility potential via a combination of quantitative ultramorphology and routine semen analysis. Hum Reprod. 1994;9:2069–2075
  13. Van Steirteghem AC, Nagy Z, Joris H, Liu J, Staessen C, Smitz J, et al.  High fertilization and implantation rates after intracytoplasmic sperm injection. Hum Reprod. 1993;8:1061–1066
  14. Bartoov B, Berkovitz A, Eltes F. Selection of spermatozoa with normal nuclei to improve the pregnancy rate with intracytoplasmic sperm injection. [letter to the Editor] N Engl J Med. 2001;345:1067–1068
  15. De Vos A, Van De Velde H, Joris H, Verheyen G, Devroey P, Van Steirteghem A. Influence of individual sperm morphology on fertilization, embryo morphology, and pregnancy outcome of intracytoplasmic sperm injection. Fertil Steril. 2003;79:42–48
  16. Koudstaal J, Van Dop PA, Hogerzeil HV, Kremer JA, Naaktgeboren N, Van Os HC, et al.  Pregnancy course and outcome in 2956 pregnancies after in-vitro fertilization in the Netherlands. Ned Tijdschr Geneeskd. 1999;143:2375–2380
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  18. Larson KL, DeJonge CJ, Barnes AM, Jost LK, Evenson DP. Sperm chromatin structure assay parameters as predictors of failed pregnancy following assisted reproductive techniques. Hum Reprod. 2000;15:1717–1722
  19. Check JH, Katsoff D, Check ML, Choe JK, Swenson K. In vitro fertilization with intracytoplasmic sperm injection is an effective therapy for male factor infertility related to subnormal hypo-osmotic swelling test scores. J Androl. 2001;22:261–265
  20. Check ML, Kiefer D, Check JH, Hourani W, Long R. Treatment of sperm with subnormal host scores with chymotrypsin/viable pregnancy after IUI. Arch Androl. 2002;48:155–158
  21. Serhal PF, Ranieri DM, Kinis A, Marchant S, Davies M, Khadum IM. Oocyte morphology predicts outcome of intracytoplasmic sperm injection. Hum Reprod. 1997;12:1267–1270
  22. Mikkelsen AL, Lindenberg S. Morphology of in-vitro matured oocytes (impact on fertility potential and embryo quality). Hum Reprod. 2001;16:1714–1718
  23. Nagy ZP, Verheyen G, Tournaye H, Van Steirteghem AC. Special applications of intracytoplasmic sperm injection (the influence of sperm count, motility, morphology, source and sperm antibody on the outcome of ICSI). Hum Reprod. 1998;13(Suppl 1):143–154
  24. Oehninger S, Chaturvedi S, Toner J, Morshedi M, Mayer J, Lanzendorf S, et al.  Semen quality (is there a paternal effect on pregnancy outcome in in-vitro fertilization/intracytoplasmic sperm injection?). Hum Reprod. 1998;13:2161–2164

PII: S0015-0282(03)02256-8

doi: 10.1016/j.fertnstert.2003.05.016

Fertility and Sterility
Volume 80, Issue 6 , Pages 1413-1419 , December 2003

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