Fertility and Sterility
Volume 81, Issue 4 , Pages 977-981 , April 2004

Blastomere transplantation in human embryos may be a treatment for single gene diseases

This study was presented in part at the Annual Meeting of ESHRE, Madrid, Spain, July 1, 2003, and was a finalist for the Senior Investigator Award. This study was also presented in part at the Annual Meeting of the ASRM, San Antonio, Texas, October 15, 2003, and was a finalist for the American Society for Reproductive Medicine's General Program Prize Paper Award.

  • Norbert Gleicher, M.D.

      Affiliations

    • Centers for Human Reproduction, New York, New York, USA
    • Foundation for Reproductive Medicine, Chicago, Illinois, USA
    • Corresponding Author InformationReprint requests: Norbert Gleicher, M.D., Center for Human Reproduction (CHR), 60 East Delaware Place, Suite 1400, Chicago, Illinois 60611, USA (FAX: 312-397-8396).
    • ,
  • Ya Xu Tang, M.D.

      Affiliations

    • Centers for Human Reproduction, New York, New York, USA
    • Foundation for Reproductive Medicine, Chicago, Illinois, USA

Received 17 April 2003 ,Revised 15 August 2003 ,Accepted 15 August 2003.

References 

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  3. Hacien-Bey-Abina S, Le Deist F, Carlier F, Bouneaud C, Hue C, De Villartay JP, et al.  Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N Engl J Med. 2002;346:1185–1193
  4. American Society of Reproductive Medicine and Society for Assisted Reproductive Technology . A Practice Committee report (preimplantation genetic diagnosis). Birmingham, AL: American Society for Reproductive Medicine; 2001;
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  9. Delhanty JD, Harper JL, Ao A, Handyside AH, Winston RM. Multicolour FISH detects frequent chromosomal mosaicism and chaotic division in normal preimplantation embryos from fertile patients. Hum Genet. 1997;99:755–760
  10. Bielanska M, Lin Tan S, Ao A. Different probe combinations for assessment of postzygotic chromosomal imbalances in human embryos. J Assist Reprod Genet. 2002;19:177–182
  11. Fuchimoto Y, Yamada K, Shimizu A, Yasumoto A, Sawada T, Huang CH, et al.  Relationship between chimerism and tolerance in a kidney transplantation model. J Immunol. 1999;162:5704–5711
  12. Quaini F, Urbanek K, Beltrami AP, Finato N, Beltrami CA, Nadal-Ginard B, et al.  Chimerism of the transplanted heart. N Engl J Med. 2002;346:5–15
  13. Alikani M, Willadsen SM. Human blastocysts from aggregated mono-nucleated cells of two or more non-viable zygote-derived embryos. Reprod Biomed Online. 2002;5:56–58
  14. Elias S. Preimplantation genetic diagnosis by comparative genomic hybridization. N Engl J Med. 2001;345:1569
  15. Orellana C. German ethics group advises against pre-implantation genetic diagnosis. Lancet. 2002;359:1926

☆ Disclosure and Conflict Statement: A patent application for the concept of blastomere transplantation has been submitted by Dr. Gleicher. The publication of this study does not involve any conflicts.

PII: S0015-0282(04)00012-3

doi: 10.1016/j.fertnstert.2003.08.055

Fertility and Sterility
Volume 81, Issue 4 , Pages 977-981 , April 2004

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