Fertility and Sterility
Volume 82, Issue 1 , Pages 167-171 , July 2004

Accelerated endometrial maturation in the luteal phase of cycles utilizing controlled ovarian hyperstimulation: impact of gonadotropin-releasing hormone agonists versus antagonists

  • Peyman Saadat, M.D.

      Affiliations

    • Keck School of Medicine of the University of Southern California, Los Angeles, and Good Samaritan Hospital, Los Angeles, California, USA
    • Corresponding Author InformationReprint requests: Peyman Saadat, M.D., Department of Obstetrics and Gynecology, Women's and Children's Hospital, 1240 North Mission Road, Room 8K9, Los Angeles, California 90033, USA (FAX: 323-226-2850; Phone: (323) 226-3026
    • ,
  • Robert Boostanfar, M.D.

      Affiliations

    • Keck School of Medicine of the University of Southern California, Los Angeles, and Good Samaritan Hospital, Los Angeles, California, USA
    • ,
  • Cristin C Slater, M.D.

      Affiliations

    • Keck School of Medicine of the University of Southern California, Los Angeles, and Good Samaritan Hospital, Los Angeles, California, USA
    • ,
  • David E Tourgeman, M.D.

      Affiliations

    • Keck School of Medicine of the University of Southern California, Los Angeles, and Good Samaritan Hospital, Los Angeles, California, USA
    • ,
  • Frank Z Stanczyk, Ph.D.

      Affiliations

    • Keck School of Medicine of the University of Southern California, Los Angeles, and Good Samaritan Hospital, Los Angeles, California, USA
    • ,
  • Richard J Paulson, M.D.

      Affiliations

    • Keck School of Medicine of the University of Southern California, Los Angeles, and Good Samaritan Hospital, Los Angeles, California, USA

Received 7 April 2003 ,Revised 25 November 2003 ,Accepted 25 November 2003.

References 

  1. Frydman R, Cornel C, de Ziegler D, Taieb J, Spitz IM, Bouchard P. Prevention of premature luteinizing hormone and progesterone rise with a gonadotropin-releasing hormone antagonist, Nal-Glu, in controlled ovarian hyperstimulation. Fertil Steril. 1991;56:923–927
  2. Frydman R, Cornel C, de Ziegler D, Taieb J, Spitz IM, Bouchard P. Spontaneous luteinizing hormone surges can be reliably prevented by the timely administration of a gonadotropin-releasing antagonist (Nal-Glu) during the late follicular phase. Hum Reprod. 1992;7:930–933
  3. Cassidenti DL, Sauer MV, Paulson RJ, Ditkoff EC, Rivier J, Yen SSC, et al.  Comparison of intermittent and continuous use of a gonadotropin-releasing hormone antagonist (Nal-Glu) in in vitro fertilization cycles (a preliminary report). Am J Obstet Gynecol. 1991;165:1806–1810
  4. Ditkoff EC, Cassidenti DL, Paulson RJ, Sauer MV, Paul WL, Rivier J, et al.  The gonadotropin-releasing hormone antagonist (Nal-Glu) acutely blocks the luteinizing hormone surge but allows for resumption of folliculogenesis in normal women. Am J Obstet Gynecol. 1991;165:1811–1817
  5. The Ganirelix Dose-Finding Study Group . A double-blind, randomized, dose-finding study to assess the efficacy of the gonadotrophin-releasing hormone antagonist ganirelix (Org 37462) to prevent premature luteinizing hormone surges in women undergoing ovarian stimulation with recombinant follicle-stimulating hormone (Puregon®). Hum Reprod. 1998;13:3023–3031
  6. The North American Ganirelix Study Group . Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation. Fertil Steril. 2001;75:38–45
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  8. Albano C, Felberbaum RE, Smitz J, Riethmuller-Winzen H, Engel J, Diedrich K, et al.  Ovarian stimulation with HMG (results of a prospective randomized phase III European study comparing the luteinizing hormone-releasing hormone (LHRH)-antagonist cetrorelix and the LHRH-agonist buserelin). Hum Reprod. 2000;15:526–531
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  24. Silverberg KM, Burns WN, Olive DL, Reihl RM, Schenken RS. Serum progesterone levels predict success of in vitro fertilization/embryo transfer in patients stimulated with leuprolide acetate and human menopausal gonadotropins. J Clin Endocrinol Metab. 1991;73:797–803
  25. Bustillo M, Stern JJ, Coulam CB. Serum progesterone at the time of human chorionic gonadotrophin does not predict in-vitro fertilization and embryo transfer. Hum Reprod. 1995;10:2862–2867
  26. Eldestien MC, Seltman HJ, Cox BJ, Robinson SM, Shaw RA, Muasher SJ. Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome. Fertil Steril. 1990;54:853–857
  27. Legro RS, Ary BA, Paulson RJ, Stanczyk FZ, Sauer MV. Premature luteinization as detected by elevated serum progesterone is associated with a higher pregnancy rate in donor oocyte in-vitro fertilization. Hum Reprod. 1993;8:1506–1511

PII: S0015-0282(04)00552-7

doi: 10.1016/j.fertnstert.2003.11.050

Fertility and Sterility
Volume 82, Issue 1 , Pages 167-171 , July 2004

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