Fertility and Sterility
Volume 82, Issue 1 , Pages 52-56 , July 2004

Platelet-activating factor significantly enhances intrauterine insemination pregnancy rates in non-male factor infertility

Presented in part (O-222) at the 58th Annual Meeting of the American Society for Reproductive Medicine, Seattle, WA, October 12–17, 2002.

  • William E Roudebush, Ph.D.

      Affiliations

    • Corresponding Author InformationReprints requests: William E. Roudebush, Ph.D., Reproductive Biology Associates, 1150 Lake Hearn Drive, Suite 400, Atlanta, Georgia 30342, USA (FAX: 404-256-8376).
    • Reproductive Biology Associates, Atlanta, Georgia, USA
    • ,
  • Andrew A Toledo, M.D.

      Affiliations

    • Reproductive Biology Associates, Atlanta, Georgia, USA
    • ,
  • Hilton I Kort, M.D.

      Affiliations

    • Reproductive Biology Associates, Atlanta, Georgia, USA
    • ,
  • Dorothy Mitchell-Leef, M.D.

      Affiliations

    • Reproductive Biology Associates, Atlanta, Georgia, USA
    • ,
  • Carlene W Elsner, M.D.

      Affiliations

    • Reproductive Biology Associates, Atlanta, Georgia, USA
    • ,
  • Joe B Massey, M.D.

      Affiliations

    • Reproductive Biology Associates, Atlanta, Georgia, USA

Received 11 August 2003 ,Revised 25 November 2003 ,Accepted 25 November 2003.

References 

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  2. Ecochard R, Mathieu C, Royere D, Blache G, Rabilloud M, Czyba JC. A randomized prospective study comparing pregnancy rates after clomiphene citrate and human menopausal gonadotropin before intrauterine insemination. Fertil Steril. 2000;73:90–93
  3. Pasqualotto EB, Daitch JA, Hendin BN, Falcone T, Thomas AJ, Nelson DR, et al.  Relationship to total motile sperm count and percentage motile sperm to successful pregnancy rates following intrauterine insemination. J Assisted Reprod Genetics. 1999;16:476–482
  4. Matorras R, Diaz T, Corcostegui B, Ramon O, Pijoan JI, Rodriguez-Escudero FJ. Ovarian stimulation in intrauterine insemination with donor sperm (a randomized study comparing clomiphene citrate in fixed protocol versus highly purified urinary FSH). Hum Reprod. 2002;8:2107–2111
  5. Silverberg KM, Johnson JV, Olive DL, Burns WN, Schenken RS. A prospective, randomized trial comparing two different intrauterine insemination regimens in controlled ovarian hyperstimulation cycles. Fertil Steril. 1992;2:357–361
  6. Cantineau AE, Heineman MJ, Cohlen BJ. Single versus double intrauterine insemination in stimulated cycles for subfertile couples (a systematic review based on a Cochrane review). Hum Reprod. 2003;18:941–946
  7. Duran EH, Morshedi M, Taylor S, Oehninger S. Sperm DNA quality predicts intrauterine insemination outcome (a prospective cohort study). Hum Reprod. 2002;17:3122–3128
  8. Harper MJK. Platelet-activating factor (a paracrine factor in preimplantation stages of development?). Biol Reprod. 1989;40:907–913
  9. Minhas BS, Kumar R, Ricker DD, Robertson JL, Dodson MG. The presence of platelet activating factor-like activity in human spermatozoa. Fertil Steril. 1991;55:372–376
  10. Roudebush WE, Purnell ET. Platelet-activating factor content in human spermatozoa (predicting pregnancy outcome). Fertil Steril. 2000;74:257–260
  11. Ricker DD, Minhas BS, Kumar R, Robertson JL, Dodson MG. The effects of platelet activating factor on the motility of human spermatozoa. Fertil Steril. 1989;52:655–658
  12. Roudebush WE, Fukuda AI, Minhas BS. Enhanced embryo development of rabbit oocytes fertilized in vitro with platelet-activating factor treated spermatozoa. J Assisted Reprod Genet. 1993;10:91–94
  13. Wild MD, Roudebush WE. Platelet-activating factor improves intrauterine insemination outcome. Am J Obstet Gynecol. 2001;184:1064–1065
  14. WHO Laboratory Manual. The examination of human semen and sperm–cervical mucus interaction. 4th ed. Prepared by WHO Special Programme for Research Development and Research Training in Human Reproduction: Cambridge University Press, Cambridge, UK 1999
  15. Purnell ET, Roudebush WE. Platelet-activating factor activity (ligand and receptor transcript) content in sperm: motile versus nonmotile. In:  Robaire E,  Chemes H,  Morales CR editor. Andrology in the 21st century, Proceedings of the VIIth International Congress of Andrology. Englewood, NJ: Medimond Publishing Company, Inc; 2001;p. 71–76
  16. Sengoku K, Tamate K, Takaoka Y, Ishikawa M. Effects of platelet-activating factor on human sperm function in vitro. Hum Reprod 1993;8:1443–7
  17. Minhas BS. Platelet-activating factor treatment of human spermatozoa enhances fertilization potential. Am J Obstet Gynecol. 1993;168:1314–1317
  18. Reinhardt JC, Cui X, Roudebush WE. Immunofluorescent evidence for the presence of the platelet-activating factor receptor in human spermatozoa. Fertil Steril. 1999;71:941–942
  19. Roudebush WE, Wild MD, Maguire EH. Platelet-activating factor receptor expression in human spermatozoa (differences in mRNA content and protein distribution between normal and abnormal spermatozoa). Fertil Steril. 2000;73:967–971
  20. Roudebush WE, Mayorov V, Adkison LR, Slayden SM, Shapiro DB, Elsner CW, et al. Abnormal sequence of the platelet-activating factor-receptor in nonmotile spermatozoa. Fertil Steril 2002;76:P-460
  21. Levine AS, Kort HI, Toledo AA, Roudebush WE. A review of the effect of platelet-activating factor on male reproduction and sperm function. J Androl. 2002;23:471–476
  22. Wu C, Stojanov T, Chami O, Ishii S, Shimizu T, Li A, et al.  Evidence for the autocrine induction of capacitation of mammalian spermatozoa. J Biol Chem. 2001;276:26962–26968
  23. Toledo AA, Mitchell-Leef D, Elsner CW, Slayden SM, Roudebush WE. Fertilization potential of human sperm is correlated with endogenous platelet-activating factor content. J Assist Reprod Genet. 2003;20:192–195

PII: S0015-0282(04)00612-0

doi: 10.1016/j.fertnstert.2003.11.057

Fertility and Sterility
Volume 82, Issue 1 , Pages 52-56 , July 2004

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