Fertility and Sterility
Volume 82, Issue 1 , Pages 234-236 , July 2004

Controlled natural in vitro fertilization may be an alternative for patients with repeated unexplained implantation failure and a high uterine natural killer cell count

  • Nathalie Lédée-Bataille, M.D., Ph.D.

      Affiliations

    • INSERM (Institut National de la Santé et de la Recherche Médicale) Unité 131, Clamart, France
    • EA (Equipe associée) 3538Clamart, France
    • Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Clamart, France
    • Corresponding Author InformationReprint requests: Nathalie Lédée-Bataille, M.D., Ph.D., Unité INSERM 131, Hôpital Antoine Béclère, 157 rue de la porte de Trivaux, 92141 Clamart Cedex, France (FAX: 33-1-45-37-44-50).
    • ,
  • Sylvie Dubanchet

      Affiliations

    • INSERM (Institut National de la Santé et de la Recherche Médicale) Unité 131, Clamart, France
    • ,
  • Jacques Kadoch, M.D.

      Affiliations

    • Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Clamart, France
    • ,
  • Altina Castelo-Branco, M.D.

      Affiliations

    • Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Clamart, France
    • ,
  • René Frydman, M.D.

      Affiliations

    • EA (Equipe associée) 3538Clamart, France
    • Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Clamart, France
    • ,
  • Gérard Chaouat, M.D., Ph.D.

      Affiliations

    • INSERM (Institut National de la Santé et de la Recherche Médicale) Unité 131, Clamart, France

Received 3 July 2003 ,Revised 8 December 2003 ,Accepted 8 December 2003.

References 

  1. Croy BA, Chantakru S, Esadeg S, Ashkar AA, Wei Q. Decidual natural killer cells (key regulators of placental development (a review)). J Reprod Immunol. 2002;57:151–168
  2. Loke YW, King A, Burrows TD. Decidua in human implantation. Hum Reprod. 1995;10(Suppl 2):14–21
  3. Guimond MJ, Luross JA, Wang B, Terhorst C, Danial S, Croy BA. Absence of natural killer cells during murine pregnancy is associated with reproductive compromise in TgE26 mice. Biol Reprod. 1997;56:169–179
  4. Ashkar AA, Croy BA. Interferon-gamma contributes to the normalcy of murine pregnancy. Biol Reprod. 1999;61:493–502
  5. Croy BA, Ashkar AA, Minhas K, Greenwood JD. Can murine uterine natural killer cells give insights into the pathogenesis of preeclampsia?. J Soc Gynecol Investig. 2000;7:12–20
  6. Chaouat G, Zourbas S, Ostojic S, Lappree-Delage G, Dubanchet S, Ledee N, et al.  A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy. J Reprod Immunol. 2002;53:241–256
  7. Coulam CB, Goodman C. Increased pregnancy rates after IVF/ET with intravenous immunoglobulin treatment in women with elevated circulating C56+ cells. Early Pregnancy. 2000;4:90–98
  8. Chaouat G, Menu E, Delage G, Moreau JF, Khrishnan L, Hui L, et al.  Immuno-endocrine interactions in early pregnancy. Hum Reprod. 1995;10(Suppl 2):55–59
  9. Hill JA, Polgar K, Anderson DJ. T-helper 1-type immunity to trophoblast in women with recurrent spontaneous abortion. JAMA. 1995;273:1933–1936
  10. Raghupathy R, Makhseed M, Azizieh F, Hassan N, Al-Azemi M, Al-Shamali E. Maternal Th1- and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortions. Cell Immunol. 1999;196:122–130
  11. Emmer PM, Nelen WL, Steegers EA, Hendriks JC, Veerhoek M, Joosten I. Peripheral natural killer cytotoxicity and CD56(pos)CD16(pos) cells increase during early pregnancy in women with a history of recurrent spontaneous abortion. Hum Reprod. 2000;15:1163–1169
  12. Levi AJ, Drews MR, Bergh PA, Miller BT, Scott RT. Controlled ovarian hyperstimulation does not adversely affect endometrial receptivity in in vitro fertilization cycles. Fertil Steril. 2001;76:670–674
  13. Check JH, Choe JK, Katsoff D, Summers-Chase D, Wilson C. Controlled ovarian hyperstimulation adversely affects implantation following in vitro fertilization-embryo transfer. J Assist Reprod Genet. 1999;16:416–420
  14. Van Der Gaast MH, Beckers NG, Beier-Hellwig K, Beier HM, Macklon NS, Fauser BC. Ovarian stimulation for IVF and endometrial receptivity—the missing link. Reprod Biomed Online. 2002;5(Suppl 1):36–43
  15. Simon C, Cano F, Valbuena D, Remohi J, Pellicer A. Clinical evidence for a detrimental effect on uterine receptivity of high serum estradiol concentrations in high and normal responder patients. Hum Reprod. 1995;10:2432–2437
  16. De Ziegler D, Fanchin R, Massonneau M, Bergeron C, Frydman R, Bouchard P. Hormonal control of endometrial receptivity. The egg donation model and controlled ovarian hyperstimulation. Ann N Y Acad Sci. 1994;734:209–220
  17. Ludwig M, Diedrich K. Evaluation of an optimal luteal phase support protocol in IVF. Acta Obstet Gynecol Scand. 2001;80:452–466
  18. Noyes RW, Hertig AT, Rock J. Dating the endometrial biopsy. Am J Obstet Gynecol. 1975;122:262–263
  19. Lédée-Bataille N, S D, K B-C, Coulomb-l'hermine A, Durand-Gasselin I, Frydman R, Chaouat G. A new role for natural killer cells, interleukin12 and 18 in repeated implantation failure after successful in vitro fertilization. Fertil Steril In press
  20. Tourgeman DE, Gentzchein E, Stanczyk FZ, Paulson RJ. Serum and tissue hormone levels of vaginally and orally administered estradiol. Am J Obstet Gynecol. 1999;180:1480–1483
  21. DeLoia JA, Stewart-Akers AM, Brekosky J, Kubik CJ. Effects of exogenous estrogen on uterine leukocyte recruitment. Fertil Steril. 2002;77:548–554
  22. Henderson TA, Saunders PT, Moffett-King A, Groome NP, Critchley HO. Steroid receptor expression in uterine natural killer cells. J Clin Endocrinol Metab. 2003;88:440–449
  23. DeLoia JA, Stewart-Akers AM, Brekosky J, Kubik C. Stimulation of uterine cell cytokine production by ovarian hormones. Am J Reprod Immunol. 2000;44:16–21

PII: S0015-0282(04)00615-6

doi: 10.1016/j.fertnstert.2003.12.030

Fertility and Sterility
Volume 82, Issue 1 , Pages 234-236 , July 2004

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