Fertility and Sterility
Volume 82, Issue 2 , Pages 405-414 , August 2004

Ovarian cancer risk associated with varying causes of infertility

Presented at the 59th Annual Meeting of the American Society for Reproductive Medicine, which was held in San Antonio, Texas, October 11–15, 2003.

  • Louise A Brinton, Ph.D.

      Affiliations

    • Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA
    • Corresponding Author InformationReprint requests: Louise A. Brinton, Ph.D., National Cancer Institute, 6120 Executive Blvd., Room 7068, Rockville, Maryland 20852-7234, USA (FAX: 301-402-0916).
  • ,
  • Emmet J Lamb, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Stanford University, Stanford, California, USA.
  • ,
  • Kamran S Moghissi, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
  • ,
  • Bert Scoccia, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois, USA
  • ,
  • Michelle D Althuis, Ph.D.

      Affiliations

    • Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA
  • ,
  • Jerome E Mabie, B.S.

      Affiliations

    • Information Management Services, Inc Rockville, Maryland, USA
  • ,
  • Carolyn L Westhoff, Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Columbia University, New York, New York, USA

Received 2 October 2003 ,Revised 12 February 2004 ,Accepted 12 February 2004.

References 

  1. Hankinson SE, Colditz GA, Hunter DJ, Willett WC, Stampfer MJ, Rosner B, et al.  A prospective study of reproductive factors and risk of epithelial ovarian cancer. Cancer. 1995;76:284–290
  2. Risch HA, Marrett LD, Howe GR. Parity, contraception, infertility, and the risk of epithelial ovarian cancer. Am J Epidemiol. 1994;140:585–597
  3. Booth M, Beral V, Smith P. Risk factors for ovarian cancer (a case-control study). Br J Cancer. 1989;60:592–598
  4. Whittemore AS, Wu ML, Paffenbarger RS, Sarles D, Kampert JB, Grosser S, et al.  Epithelial ovarian cancer and the ability to conceive. Cancer Res. 1989;49:4047–4052
  5. Klip H, Burger CW, Kenemans P, van Leeuwen FE. Cancer risk associated with subfertility and ovulation induction (a review). Cancer Causes Control. 2000;11:319–344
  6. DePriest PD, Banks ER, Powell DE, van Nagell JR, Gallion HH, Puls SE, et al.  Endometrioid carcinoma of the ovary and endometriosis (the association in postmenopausal women). Gynecol Oncol. 1992;47:71–75
  7. Heaps JM, Nieberg RK, Berek JS. Malignant neoplasms arising in endometriosis. Obstet Gynecol. 1990;75:1023–1028
  8. Jimbo H, Yoshikawa H, Onda T, Yasugi T, Sakamoto A, Taketani Y. Prevalence of ovarian endometriosis in epithelial ovarian cancer. Int J Gynecol Obstet. 1997;59:245–250
  9. LaGrenade A, Silverberg SG. Ovarian tumors associated with atypical endometriosis. Hum Pathol. 1988;19:1080–1084
  10. Moll Um, Chumas JC, Chalas E, Mann WJ. Ovarian carcinoma arising in atypical endometriosis. Obstet Gynecol. 1990;75:537–539
  11. Sainz de la Cuesta R, Eichhorn JH, Rice LW, Fuller AF, Mikrui N, Goff BA. Histologic transformation of benign endometriosis to early epithelial ovarian cancer. Gynecol Oncol. 1996;60:238–244
  12. Vercellini P, Parazzini F, Bolis G, Carinelli S, Dindelli M, Vendola N, et al.  Endometriosis and ovarian cancer. Am J Obstet Gynecol. 1993;169:181–182
  13. Modesitt SC, Tortolero-Luna G, Robinson JB, Gershenson DM, Wolf JK. Ovarian and extraovarian endometriosis-associated cancer. Obstet Gynecol. 2002;100:788–795
  14. Oral E, Ilvan S, Tustas E, Korbeyli B, Bese T, Demirkiran F, et al.  Prevalence of endometriosis in malignant epithelial ovary tumours. Eur J Obstet Gynecol Reprod Biol. 2003;109:97–101
  15. Stern RC, Dash R, Bentley RC, Snyder MJ, Haney AF, Robboy SJ. Malignancy in endometriosis (frequency and comparison of ovarian and extraovarian types). Int J Gynecol Pathol. 2001;20:133–139
  16. Brinton LA, Gridley G, Persson I, Baron J, Bergqvist A. Cancer risk after a hospital discharge diagnosis of endometriosis. Am J Obstet Gynecol. 1997;176:572–579
  17. Ness RB, Cramer DW, Goodman MT, Kruger Kjaer S, Mallin K, Mosgaard BJ, et al.  Infertility, fertility drugs, and ovarian cancer (a pooled analysis of case-control studies). Am J Epidemiol. 2003;155:217–224
  18. Rossing MA, Daling JR, Weiss NS, Moore DE, Self SG. Ovarian tumors in a cohort of infertile women. N Engl J Med. 1994;331:771–776
  19. Meirow D, Schenker JG. The link between female infertility and cancer (epidemiology and possible aetiologies). Hum Reprod Update. 2003;2:63–75
  20. Schildkraut JM, Schwingl PJ, Bastos E, Evanoff A, Hughes C. Epithelial ovarian cancer risk among women with polycystic ovary syndrome. Obstet Gynecol. 1996;88:554–559
  21. Ness RB, Cottreau C. Possible role of ovarian epithelial inflammation in ovarian cancer. J Natl Cancer Inst. 1999;91:1459–1467
  22. Ness RB, Grisso JA, Cottreau C, Klapper J, Vergona R, Wheeler JE, et al.  Factors related to inflammation of the ovarian epithelium and risk of ovarian cancer. Epidemiology. 2000;11:111–117
  23. Risch HA, Howe GR. Pelvic inflammatory disease and the risk of epithelial ovarian cancer. Cancer Epidemiol Biomark Prev. 1995;4:447–451
  24. Shu X, Brinton LA, Gao YT, Yuan JM. Population-based case-control study of ovarian cancer in Shanghai. Cancer Res. 1989;49:3670–3674
  25. Breslow NE, Day NE. Statistical methods in cancer research. Vol. 2. The design and analysis of cohort studies. International Agency for Research on Cancer: Lyon, France, 1987
  26. Ron E, Lunenfeld B, Menczer J, Blumstein T, Katz L, Oelsner G, et al.  Cancer incidence in a cohort of infertile women. Am J Epidemiol. 1987;125:780–790
  27. Modan B, Ron E, Lerner-Geva L, Blumstein T, Menczer J, Rabinovici J, et al.  Cancer incidence in a cohort of infertile women. Am J Epidemiol. 1998;147:1038–1042
  28. Brugo-Olmedo S, Chillik C, Kopelman S. Definition and causes of infertility. Reprod Biomed Online. 2001;2:41–53
  29. Smith S, Pfeifer SM, Collins JA. Diagnosis and management of female infertility. JAMA. 2003;290:1767–1770
  30. Whittemore AS, Harris R, Itnyre J  the Collaborative Ovarian Cancer Group . Characteristics relating to ovarian cancer risk (collaborative analysis of 12 US case-control studies. II. Invasive epithelial ovarian cancers in white women). Am J Epidemiol. 1992;136:1184–1203
  31. Duczman L, Ballweg ML. Endometriosis and cancer (what is the connection?). Endometr Assoc Newsl. 1999;20
  32. Ness RB. Endometriosis and ovarian cancer (thoughts on shared pathophysiology). Am J Obstet Gynecol. 2003;189:289–294
  33. Coulam CB, Annegers JF, Kranz JS. Chronic anovulation syndrome and associated neoplasia. Obstet Gynecol. 1983;61:403–407
  34. Green A, Purdie D, Bain C, Siskind V, Russell P, Quinn M, et al.  Tubal sterilisation, hysterectomy and decreased risk of ovarian cancer. Survey of Women's Health Study Group. Int J Cancer. 1997;71:948–951
  35. Hankinson SE, Hunter DJ, Colditz GA, Willett WC, Stampfer MJ, Rosner B, et al.  Tubal ligation, hysterectomy, and risk of ovarian cancer. A prospective study. JAMA. 1993;270:2813–2818
  36. Kreiger N, Sloan M, Cotterchio M, Parsons P. Surgical procedures associated with risk of ovarian cancer. Int J Epidemiol. 1997;26:710–715
  37. Miracle-McMahill HL, Calle EE, Kosinski AS, Rodriguez C, Wingo PA, Thun MJ, et al.  Tubal ligation and fatal ovarian cancer in a large prospective cohort study. Am J Epidemiol. 1997;145:349–357
  38. Rosenblatt KA, Thomas DB. Reduced risk of ovarian cancer in women with a tubal ligation or hysterectomy. The World Health Organization Collaborative Study of Neoplasia and Steroid Contraceptives. Cancer Epidemiol Biomark Prev. 1996;5:933–935
  39. Ellsworth LR, Allen HH, Nisker JA. Ovarian function after radical hysterectomy for stage IB carcinoma of cervix. Am J Obstet Gynecol. 1983;145:185–188
  40. Venn A, Watson L, Bruinsma F, Giles G, Healy D. Risk of cancer after use of fertility drugs with in-vitro fertilisation. Lancet. 1999;354:1586–1590
  41. Cahill DJ, Hull MGR. Pituitary-ovarian dysfunction and endometriosis. Hum Reprod Update. 2000;6:56–66

 Supported by National Cancer Institute intramural funds.

PII: S0015-0282(04)00879-9

doi: 10.1016/j.fertnstert.2004.02.109

Fertility and Sterility
Volume 82, Issue 2 , Pages 405-414 , August 2004