Fertility and Sterility
Volume 82, Issue 4 , Pages 775-779, October 2004

Assisted reproductive techniques in patients with Klinefelter syndrome: A critical review

  • Dominik Denschlag, M.D.

      Affiliations

    • Department of Obstetrics and GynecologyUniversity of Freiburg, Freiburg, Germany
    • Corresponding Author InformationReprint requests: Dominik Denschlag, M.D., Department of Obstetrics and Gynecology, University of Freiburg School of Medicine, Hugstetter Strasse 55, Freiburg D-79106, Germany (FAX: 49-761-2703037
    • ,
  • Clemens Tempfer, M.D.

      Affiliations

    • Department of Obstetrics and GynecologyUniversity of Freiburg, Freiburg, Germany
    • ,
  • Myriam Kunze, M.D.

      Affiliations

    • Department of Obstetrics and GynecologyUniversity of Freiburg, Freiburg, Germany
    • ,
  • Gerhard Wolff, M.D.

      Affiliations

    • Institute of Human GeneticsUniversity of Freiburg, Freiburg, Germany
    • ,
  • Christoph Keck, M.D.

      Affiliations

    • Department of Obstetrics and GynecologyUniversity of Freiburg, Freiburg, Germany

Received 24 June 2003; received in revised form 15 September 2003; accepted 15 September 2003.

Objective

To summarize the existing experience with the use and success rate of assisted reproductive techniques (ART), in particular testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI), in Klinefelter patients.

Design

A systematic review of the literature, including all published case reports to date.

Patient(s)

Thirty-nine reported successful pregnancies fathered by nonmosaic Klinefelter patients.

Main outcome measure(s)

The overall risk of transmitting a chromosomal abnormality to the offspring of Klinefelter patients.

Result(s)

In nonmosaic and mosaic Klinefelter patients, chromosomally normal sperm cells can be extracted from testicular tissue and used for ICSI.

Conclusion(s)

The application of ART to Klinefelter patients can be recommended as a method to achieve reproduction in this selected infertility patient cohort.

Key words:  Klinefelter syndrome , male infertility , ICSI , TESE , genetic counseling

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PII: S0015-0282(04)01248-8

doi:10.1016/j.fertnstert.2003.09.085

Fertility and Sterility
Volume 82, Issue 4 , Pages 775-779, October 2004

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