CA-125 serum levels and pregnancy outcome in in vitro fertilization

Fish, Karen E.; Phipps, Maureen; Trimarchi, James; Weitzen, Sherry; Blazar, Andrew S.

doi:10.1016/j.fertnstert.2004.07.951

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Volume 82, Issue 6 , Pages 1705-1707, December 2004

CA-125 serum levels and pregnancy outcome in in vitro fertilization

Karen E. Fish, M.D.
- Department of Obstetrics and Gynecology
- Brown Medical School, Providence, Rhode Island
Maureen Phipps, M.D., M.P.H.
- Department of Obstetrics and Gynecology
- Brown Medical School, Providence, Rhode Island
- Division of Research
James Trimarchi, Ph.D.
- Department of Obstetrics and Gynecology
- Brown Medical School, Providence, Rhode Island
- Division of Reproductive Medicine and Infertility, Women & Infants' Hospital of Rhode Island
Sherry Weitzen, Ph.D.
- Department of Obstetrics and Gynecology
- Brown Medical School, Providence, Rhode Island
- Division of Research
Andrew S. Blazar, M.D.
- Department of Obstetrics and Gynecology
- Brown Medical School, Providence, Rhode Island
- Division of Reproductive Medicine and Infertility, Women & Infants' Hospital of Rhode Island
- Reprints requests: Andrew S. Blazar, M.D., Women & Infants' Hospital of Rhode Island, 101 Dudley Street, Providence, RI 02905 (FAX: 401-453-7599

Received 21 November 2003; received in revised form 27 July 2004; accepted 27 July 2004.

This is a prospective cohort study of CA-125 levels drawn on the day of hCG administration in 386 women undergoing IVF treatment. The CA-125 levels were not helpful in determining pregnancy outcome, as indicated by poor sensitivity (40.8%) and specificity (52.7%), as well as an area under the receiver operator characteristic curve close to 0.50.