Mutations in the human BOULE gene are not a major cause of impaired spermatogenesis

Westerveld, G. Henrike; Repping, Sjoerd; Leschot, Nico J.; van der Veen, Fulco; Lombardi, M. Paola

doi:10.1016/j.fertnstert.2004.10.013

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Volume 83, Issue 2 , Pages 513-515, February 2005

Mutations in the human BOULE gene are not a major cause of impaired spermatogenesis

G. Henrike Westerveld, M.D.
- Center for Reproductive Medicine, Department of Obstetrics and Gynaecology
- Reprint requests: Henrike Westerveld, M.D., Center for Reproductive Medicine, Department of Obstetrics and Gynaecology, Academic Medical Center, Meibergdreef 9, H4-205, 1105 AZ Amsterdam, The Netherlands, FAX:+31-20-6963489).
Sjoerd Repping, Ph.D.
- Center for Reproductive Medicine, Department of Obstetrics and Gynaecology
Nico J. Leschot, M.D., Ph.D.
- Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands
Fulco van der Veen, M.D., Ph.D.
- Center for Reproductive Medicine, Department of Obstetrics and Gynaecology
M. Paola Lombardi, Ph.D.
- Center for Reproductive Medicine, Department of Obstetrics and Gynaecology
- Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands

Received 3 May 2004; received in revised form 14 July 2004; accepted 14 July 2004.

Mutation screening of the BOULE gene in 156 men with azoospermia or severe oligozoospermia revealed no relevant mutations; thus, mutations in BOULE can be eliminated as a major cause of impaired spermatogenesis.