Fertility and Sterility
Volume 83, Issue 3 , Pages 649-658 , March 2005

Preimplantation sex selection demand and preferences in an infertility population

  • Tarun Jain, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • Department of Obstetrics and Gynecology, University of Illinois Medical Center, Chicago, Illinois
    • Corresponding Author InformationReprint requests: Tarun Jain, M.D., Division of Reproductive Endocrinology and Infertility, University of Illinois Medical Center, 820 South Wood Street, M/C 808, Chicago, IL 60612 (FAX: 312-996-4238)
    • ,
  • Stacey A. Missmer, Sc.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • ,
  • Raina S. Gupta, B.A.

      Affiliations

    • Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    • ,
  • Mark D. Hornstein, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts

Received 17 June 2004 ,Revised 26 August 2004 ,Accepted 26 August 2004.

References 

  1. Handyside AH , Pattinson JK , Penketh RJ , Delhanty JD , Winston RM , Tuddenham EG . Biopsy of human preimplantation embryos and sexing by DNA amplification . Lancet . 1989;1:347–349
  2. Handyside AH , Kontogianni EH , Hardy K , Winston RM . Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification . Nature . 1990;344:768–770
  3. Soussis I , Harper JC , Handyside AH , Winston RM . Obstetric outcome of pregnancies resulting from embryos biopsied for pre-implantation diagnosis of inherited disease . Br J Obstet Gynaecol . 1996;103:784–788
  4. Preimplantation genetic diagnosis—an integral part of assisted reproduction. Report of the 9th Annual Meeting of the International Working Group on Preimplantation Genetics. J Assist Reprod Genet 2000;17:75–9.
  5. Malpani A , Malpani A , Modi D . Preimplantation sex selection for family balancing in India . Hum Reprod . 2002;17:11–12
  6. Johnson LA , Welch GR , Keyvanfar K , Dorfmann A , Fugger EF , Schulman JD . Gender preselection in humans? Flow cytometric separation of X and Y spermatozoa for the prevention of X-linked diseases . Hum Reprod . 1993;8:1733–1739
  7. Vidal F , Fugger EF , Blanco J , Keyvanfar K , Catala V , Norton M , et al.  Efficiency of MicroSort flow cytometry for producing sperm populations enriched in X- or Y-chromosome haplotypes: a blind trial assessed by double and triple colour fluorescent in-situ hybridization . Hum Reprod . 1998;13:308–312
  8. Fugger EF , Black SH , Keyvanfar K , Schulman JD . Births of normal daughters after microsort sperm separation and intrauterine insemination, in-vitro fertilization, or intracytoplasmic sperm injection . Hum Reprod . 1998;13:2367–2370
  9. accessed August 20, 2004) http://www.microsort.net/index.htm
  10. ESHRE PGD Consortium Steering Committee . ESHRE Preimplantation Genetic Diagnosis Consortium: data collection III (May 2001) . Hum Reprod . 2002;17:233–246
  11. Kalb C. Brave New Babies. Newsweek 26 Jan, 2004.
  12. The President's Council on Bioethics. Beyond therapy—Biotechnology and the pursuit of happiness. Washington, D.C., October 2003 . http://www.bioethics.gov
  13. Wade N. Bush's advisers on biotechnology express concern on its use. The New York Times 17 Oct, 2003.
  14. The President's Council on Bioethics. Reproduction and responsibility: the regulation of new biotechnologies. Washington, D.C., March 2004 . http://www.bioethics.gov
  15. American College of Obstetrics and Gynecology . Sex selection . In: Ethics in Obstetrics and Gynecology . Washington, D.C.: ACOG; 2002;
  16. FIGO . Recommendations on ethical issues in obstetrics and gynecology by the FIGO Committee for the Ethical Aspects of Human Reproduction and Women's Health . London: FIGO; 2000;
  17. Ethics Committee of the American Society for Reproductive Medicine . Preconception gender selection for nonmedical reasons . Fertil Steril . 2001;75:861–864
  18. Robertson JA . Sex selection for gender variety by preimplantation genetic diagnosis . Fertil Steril . 2002;78:463
  19. Human Fertilisation and Embryology Authority. Sex selection: options for regulation. London: HFEA, 2003 . http://www.hfea.gov.uk/AboutHFEA/Consultations
  20. Robertson JA . Gender variety as a valid choice: a comment on the HFEA—response to Edgar Dahl's “The presumption in favour of liberty.” . Reprod Biomed Online . 2004;8:270–271
  21. Dahl E , Beutel M , Brosig B , Hinsch KD . Preconception sex selection for non-medical reasons: a representative survey from Germany . Hum Reprod . 2003;18:2231–2234
  22. Parikh FR . Ethical differences between sex selection by sperm and embryo? . Fertil Steril . 2002;77:202
  23. Rothman KJ , Greenland S . Modern epidemiology, 2nd ed . Philadelphia: Lippincott-Raven; 1998;
  24. Greenland S . Modeling and variable selection in epidemiologic analysis . Am J Public Health . 1989;79:340–349
  25. Hosmer DW , Lemeshow S . Applied logistic regression . New York: Wiley; 1989;
  26. Robertson JA . Preconception gender selection . Am J Bioeth . 2001;1:2–9
  27. Robertson JA . Extending preimplantation genetic diagnosis: the ethical debate (Ethical issues in new uses of preimplantation genetic diagnosis) . Hum Reprod . 2003;18:465–471
  28. Sen A . More than 100 million women are missing . New York Review of Books . 1990;37:61–68
  29. Allahbadia GN . The 50 million missing women . J Assist Reprod Genet . 2002;19:411–416
  30. Simpson JL , Carson SA . The reproductive option of sex selection . Hum Reprod . 1999;14:870–872
  31. Savulescu J , Dahl E . Sex selection and preimplantation diagnosis (A response to the Ethics Committee of the American Society of Reproductive Medicine) . Hum Reprod . 2000;15:1879–1880
  32. Lyons L. Oh boy: Americans still prefer sons. The Gallup Organization 23 Sep, 2003.
  33. The Vatican. Catechism of the Catholic Church. Article 6: The sixth commandment . accessed June 15, 2004) http://www.vatican.va/archive/ccc_css/archive/catechism/p3s2c2a6.htm#2377
  34. Mabrey V. Babies by design. 60 Minutes II. CBC News 14 Apr, 2004.
  35. Onion A. Congratulations! It's a (Insert Choice)! ABC News 26 Apr, 2004.

PII: S0015-0282(04)03120-6

doi: 10.1016/j.fertnstert.2004.11.023

Fertility and Sterility
Volume 83, Issue 3 , Pages 649-658 , March 2005

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