Fertility and Sterility
Volume 83, Issue 4 , Pages 1041.e1-1041.e3, April 2005

Live birth of healthy triplets after in vitro fertilization and embryo transfer in an acromegalic woman with elevated growth hormone

  • Navid Esfandiari, D.V.M., Ph.D.
    • ,
  • Lynda Gotlieb, R.N.
    • ,
  • Robert F. Casper, M.D., F.R.C.S.(C.)

      Affiliations

    • Corresponding Author InformationReprint requests: Robert F. Casper, M.D., F.R.C.S.(C.), Toronto Centre for Advanced Reproductive Technology, 210-150 Bloor Street West, Toronto, Ontario, M5S 2X9, Canada (FAX: 416-972-0036)

Toronto Centre for Advanced Reproductive Technology, Toronto, Ontario, Canada

Received 22 June 2004; received in revised form 5 October 2004; accepted 5 October 2004.

Objective

To report a case of successful triplet pregnancy in an acromegaly patient with IVF and embryo transfer.

Design

Case report.

Setting

Tertiary center for assisted reproductive technologies.

Patient(s)

A 33-year-old woman with acromegaly and primary infertility.

Intervention(s)

Controlled ovulation hyperstimulation and IVF/embryo-transfer treatment using gonadotropins.

Main outcome measure(s)

Uncomplicated pregnancy course and successful take-home triplet infant girls.

Result(s)

Successful ovarian stimulation and IVF is possible in acromegalic patients.

Conclusion(s)

There may be an effect of elevated growth hormone resulting in increased ovarian response to gonadotropin, inducing hyperstimulation and high-order multiple pregnancies in these patients.

Key words:  Acromegaly , growth hormone , ovarian hyperstimulation , in vitro fertilization , multiple pregnancy

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PII: S0015-0282(04)03171-1

doi:10.1016/j.fertnstert.2004.10.034

Fertility and Sterility
Volume 83, Issue 4 , Pages 1041.e1-1041.e3, April 2005

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