Fertility and Sterility
Volume 84, Issue 3 , Pages 605-610 , September 2005

In vitro fertilization in Sweden: child morbidity including cancer risk

  • Bengt Källén, Ph.D.

      Affiliations

    • Tornblad Institute, University of Lund, Lund, Sweden
    • Corresponding Author InformationReprint requests: Bengt Källén, Ph.D., Centre for Reproduction Epidemiology, Tornblad Institute, Biskopsgatan 7, Lund SE-223 62, Sweden (FAX: 46-46-222-4226).
    • ,
  • Orvar Finnström, Ph.D.

      Affiliations

    • Department of Pediatrics, University Hospital, Linköping, Sweden
    • ,
  • Karl-Gösta Nygren, Ph.D.

      Affiliations

    • Fertility Clinic, Sophiahemmet, Stockholm, Sweden
    • ,
  • Petra Otterblad Olausson, Ph.D.

      Affiliations

    • Centre for Epidemiology, National Board of Health and Welfare, Stockholm, Sweden

Received 8 November 2004 ,Revised 3 March 2005 ,Accepted 3 March 2005.

References 

  1. Ericson A , Nygren KG , Otterblad Olausson P , Källén B . Hospital care utilization of infants born after IVF . Hum Reprod . 2002;17:929–932
  2. Strömberg B , Dahlquist G , Ericson A , Finnström O , Köster M , Stjernqvist K . Neurological sequelae in children born after in-vitro fertilisation (a population-based study) . Lancet . 2002;359:461–465
  3. National Board of Health and Welfare, Centre for Epidemiology. The Swedish Medical Birth Register—a summary of content and quality. Available at: http://www.sos.se/FULLTEXT/112/2003-112-3/2003-112-3.pdf. Accessed Oct. 1, 2004.
  4. Källén B , Finnström O , Nygren K-G , Otterblad Olausson P . In vitro fertilization in Sweden (Infant outcome after different fertilization methods) . Fertil Steril . 2005;84:611–617
  5. Källén B , Finnström O , Nygren K-G , Otterblad Olausson P . In vitro fertilization (IVF) in Sweden (Risk for congenital malformations after different IVF methods) . Birth Defects Res (Part A) . 2005;73:162–169
  6. National Board of Health and Welfare, Centre for Epidemiology. The Swedish Hospital Discharge Register. Available at: http://www.sos.se/epc/english/ParEng.thm.
  7. National Board of Health and Welfare, Centre for Epidemiology. Cancer incidence in Sweden 2002. Available at: http://www.sos.se/FULLTEXT/42/2003-42-11/2003-42-11.pdf.
  8. Rooul-Duval A , Bertrand-Servais M , Letur-Kornisch H , Frydman R . Psychological follow-up of children born after in-vitro fertilization . Hum Reprod . 1994;9:1097–1101
  9. Saunders K , Spensley J , Munro J , Halasz G . Growth and physical outcome of children conceived by in vitro fertilization . Pediatrics . 1996;97:688–692
  10. Koivurova S , Hartikainen AL , Sovio U , Gissler M , Hemminki E , Jarvellin MR . Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF . Hum Reprod . 2003;18:2328–2336
  11. Place I , Englert Y . A prospective longitudinal study of the physical, psychomotor, and intellectual development of singleton children up to 5 years who were conceived by intracytoplasmic sperm injection compared with children conceived spontaneously and by in vitro fertilization . Fertil Steril . 2003;80:1388–1397
  12. Olivennes F , Blancket V , Kerbrat V , Fanchin R , Rufat P , Frydman R . Follow-up of a cohort of 422 children aged 6 to 13 years conceived by in vitro fertilization . Fertil Steril . 1997;67:284–289
  13. Leslie GI , Gibson FL , McMahon C , Tennant C , Saunders DM . Infants conceived using in-vitro fertilization do not over-utilize health care resources after the neonatal period . Hum Reprod . 1998;13:2055–2059
  14. Leslie GI , Gibson FL , McMahon C , Cohen J , Saunders DM , Tennant C . Children conceived using ICSI do not have an increased risk of delayed mental development at 5 years of age . Hum Reprod . 2003;18:2067–2072
  15. Ericson A , Källén B . Congenital malformations in infants born after IVF (a population based study) . Hum Reprod . 2001;16:504–509
  16. Bonduelle M , Ponjaert I , van Steirteghen A , Derde M-P , Devroey P , Liebaers L . Developmental outcome at 2 years of age for children born after ICSI compared with children born after IVF . Hum Reprod . 2003;18:342–350
  17. Bonduelle M , Bergh C , Niklasson A , Palermo GD , Wennerholm UB . Medical follow-up study of 5-year old ICSI children . Reprod BioMed Online . 2004;9:91–101
  18. Bruinsma F , Venn A , Lancaster P , Speirs A , Healy D . Incidence of cancer in children born after in-vitro fertilization . Hum Reprod . 2000;15:604–607
  19. Klip H , Burger CW , de Kraker J , van Leeuwen FE  OMEGA-project group . Risk of cancer in the offspring of women who underwent ovarian stimulation for IVF . Hum Reprod . 2001;16:2452–2458
  20. Moll AC , Imhof SM , Cruysberg JRM , Schouten-van Meeteren AYN , Boers M , van Leeuwen FE . Incidence of retinoblastoma in children born after in-vitro fertilization . Lancet . 2003;361:309–310

 Supported by a grant from the K. and A. Wallenberg Foundation (KAW 2001-0124), Stockholm, Sweden (to B.K.).

PII: S0015-0282(05)01036-8

doi: 10.1016/j.fertnstert.2005.03.035

Fertility and Sterility
Volume 84, Issue 3 , Pages 605-610 , September 2005

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