Fertility and Sterility
Volume 84, Issue 5 , Pages 1318-1319 , November 2005

Congenital abnormalities in children born after assisted reproductive techniques: how much is associated with the presence of infertility and how much with its treatment?

  • William M. Buckett, M.D.

      Affiliations

    • Corresponding Author InformationReprint requests: William Buckett, M.D., McGill University, Department of Obstetrics and Gynecology, Royal Victoria Hospital–F6.91, 687 avenue des Pins Ouest, Montréal, Québec H3A 1A1, Canada (FAX: 514-843-1496).
    • ,
  • Seang Lin Tan, M.B.B.S.

Received 20 April 2005 ,Revised 20 April 2005 ,Accepted 20 April 2005.

References 

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  2. Tan SL , Doyle P , Campbell S , Beral V , Rizk B , Brinsden P , et al.   Obstetric outcome of in vitro fertilization pregnancies compared with normally conceived pregnancies . Am J Obstet Gynecol . 1992;167:778–784
  3. Morin NC , Wirth FH , Johnson DH , Frank LM , Presburg NJ , van der Water VL , et al.   Congenital malformations and psychosocial development in children conceived by in vitro fertilization . J Pediatr . 1989;115:222–227
  4. Rizk B , Doyle P , Tan SL , Rainsbury P , Betts J , Brindsen P , et al.   Perinatal outcome and congenital malformations in IVF babies from the Bourn-Hallam . Hum Reprod . 1991;6:1259–1264
  5. Sutcliffe AG , D’Souza SW , Cadman J , Richards B , McKinlay IA , Lieberman B . Minor congenital anomalies, major congenital malformations and development in children conceived from cryopreserved embryos . Hum Reprod . 1995;10:3332–3337
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  8. Hansen M , Bower C , Milne E , de Klerk N , Kurinczuk JJ . Assisted reproductive technologies and the risk of birth defects—a systematic review . Hum Reprod . 2005;20:328–338
  9. Klemetti R , Gissler M , Sévon T , Koivurova S , Ritvanen A , Hemminki E . Children born after assisted fertilization have an increased rate of major congenital anomalies . Fertil Steril . 2005;84:1300–1307
  10. Draper ES , Kurinczuk JJ , Abrams KR , Clarke M . Assessment of separate contributions to perinatal mortality of infertility history and treatment (a case control analysis) . Lancet . 1999;353:1746–1749
  11. Buckett W , Aird L , Luckas M , Kingsland C , Lewis-Jones I , Howard P . Intracytoplasmic sperm injection. Karyotyping should be done before treatment . Br Med J . 1996;313:1334
  12. Gekas J , Thepot F , Turleau C , Siffroi JP , Dadoune JP , Briault S , et al.   Chromosomal factors of infertility in candidate couples for ICSI (an equal risk of constitutional aberrations in women and men) . Hum Reprod . 2001;16:82–90
  13. Chang AS , Moley KH , Wangler M , Feinberg AP , Debaun MR . Association between Beckwith-Wiedemann syndrome and assisted reproductive technology (a case series of 19 patients) . Fertil Steril . 2005;83:349–354
  14. Ludwig M , Katalinic A , Gross S , Sutcliffe A , Varon R , Horsthemke B . Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples . J Med Genet . 2005;42:289–291
  15. Kuwata T , Matsubara S , Ohkuchi A , Watanabe T , Izumi A , Honma Y , et al.   The risk of birth defects in dichorionic twins conceived by assisted reproductive technology . Twin Res . 2004;7:223–227

PII: S0015-0282(05)02924-9

doi: 10.1016/j.fertnstert.2005.04.065

Fertility and Sterility
Volume 84, Issue 5 , Pages 1318-1319 , November 2005

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