Fertility and Sterility
Volume 84, Issue 5 , Pages 1300-1307 , November 2005

Children born after assisted fertilization have an increased rate of major congenital anomalies

Presented at the Conference of Health Technology Assessment International, May 30–June 2, 2004, Krakow, Poland.

  • Reija Klemetti, M.H.Sc.

      Affiliations

    • Health Services Research, National Research and Development Centre for Welfare and Health (STAKES), Helsinki, Finland
    • Corresponding Author InformationReprint requests: Reija Klemetti, M.H.Sc., STAKES, Health Services Research, P.O. Box 220, Helsinki 00531, Finland (FAX: 358-9-3967-2496).
    • ,
  • Mika Gissler, D.Phil.

      Affiliations

    • Information Unit, National Research and Development Centre for Welfare and Health (STAKES), Helsinki, Finland
    • ,
  • Tiina Sevón

      Affiliations

    • Health Services Research, National Research and Development Centre for Welfare and Health (STAKES), Helsinki, Finland
    • ,
  • Sari Koivurova, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, University Hospital of Oulu, Oulu, Finland
    • ,
  • Annukka Ritvanen, M.D.

      Affiliations

    • Information Unit, National Research and Development Centre for Welfare and Health (STAKES), Helsinki, Finland
    • ,
  • Elina Hemminki, M.D. Dr. P.H.

      Affiliations

    • Health Services Research, National Research and Development Centre for Welfare and Health (STAKES), Helsinki, Finland

Received 8 November 2004 ,Revised 2 March 2005 ,Accepted 2 March 2005.

References 

  1. Gissler M . Hedelmällisyys Suomessa ennen, nyt ja tulevaisuudessa. (Fertility in Finland in the past, present and future.) . Yhteiskuntapolitiikka . 2003;6:553–565
  2. Anthony S , Buitendijk SE , Dorrepaal CA , Lindner K , Braat DDM , den Ouden AL . Congenital malformations in 4224 children conceived after IVF . Hum Reprod . 2002;17:2089–2095
  3. Bergh T , Ericson A , Hillensjö T , Nygren K-G , Wennerholm U-B . Deliveries and children born after in-vitro fertilisation in Sweden 1982–95 (A retrospective cohort study) . Lancet . 1999;354:1579–1585
  4. Dhont M , De Sutter P , Ruyssinck G , Martens G , Bekaert A . Perinatal outcome of pregnancies after assisted reproduction (a case-control study) . Am J Obstet Gynecol . 1999;181:688–695
  5. Wennerholm U-B , Bergh C , Hamberger L , Lundin K , Nilsson L , Wikland M , et al.   Incidence of congenital malformations in children born after ICSI . Hum Reprod . 2000;15:944–948
  6. Ericson A , Källén B . Congenital malformations in infants born after IVF (a population-based study) . Hum Reprod . 2001;16:504–509
  7. Hansen M , Kurinczuk J , Bower C , Webb S . The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization . N Engl J Med . 2002;346:727–730
  8. Koivurova S , Hartikainen A-L , Sovio U , Gissler M , Hemminki E , Järvelin M-R . Neonatal outcome and congenital malformations in children born after in vitro fertilization . Hum Reprod . 2002;17:1391–1398
  9. Katalanic A , Rösch C , Ludwig M . Pregnancy course and outcome after intracytoplasmic sperm injection (a controlled, prospective cohort study) . Fertil Steril . 2004;81:1604–1616
  10. Loft A , Petersen K , Erb K , Mikkelsen AL , Grinsted J , Hald F , et al.   A Danish national cohort of 730 infants born after intracytoplasmic sperm injection (ICSI) 1994–1997 . Hum Reprod . 1999;14:2143–2148
  11. Westergaard HB , Tranberg Johanssen AM , Erb K , Nyboe Andersen A . Danish National In-Vitro Fertilization Registry 1994 and 1995 (a controlled study of births, malformations and cytogenetic findings) . Hum Reprod . 1999;14:1896–1902
  12. Sutcliffe AG , Taylor B , Saunders K , Thornton S , Lieberman BA , Grudzinskas JG . Outcome in the second year of life after in-vitro fertilisation by intracytoplasmic sperm injection (a UK case-control study) . Lancet . 2001;357:2080–2084
  13. Rizk B , Doyle P , Tan SL , Rainsbury P , Betts J , Brinsden P , et al.   Perinatal outcome and congenital malformations in in-vitro fertilization babies from the Bourn-Hallam group . Hum Reprod . 1991;6:1259–1264
  14. Källen B , Otterblad Olausson P , Nygren KG . Neonatal outcome in pregnancies from ovarian stimulation . Obstet Gynecol . 2002;100:414–419
  15. Hemminki E , Klemetti R , Rintapaavola M , Martikainen J . Identifying exposures from drug reimbursement files (a study on unintended effects of in-vitro-fertilization in Finland) . Med Inform Internet Med . 2003;28:279–289
  16. Gissler M , Klemetti R , Sevón T , Hemminki E . Monitoring of IVF birth outcomes in Finland (a data quality study) . BMC Med Inform Decis Mak . 2004;4:3
  17. Teperi J . Multi-method approach to the assessment of data quality in the Finnish Medical Birth Registry . J Epidemiol Community Health . 1993;47:242–247
  18. Gissler M , Teperi J , Hemminki E , Meriläinen J . Data quality after restructuring a nationwide medical birth registry . Scand J Soc Med . 1995;23:75–80
  19. Mastroiacovo P , Castilla EE , Arpino C , Botting B , Cocchi G , Goujard J , et al.   Congenital malformations in twins (an international study) . Am J Med Genet . 1999;83:117–124
  20. Pinborg A , Loft A , Rasmussen S , Schimdt L , Langhoff-Roos J , Greisen G , et al.   Neonatal outcome in a Danish national cohort of 3438 IVF/ICSI and 10 362 non-IVF/ICSI twins born between 1995 and 2000 . Hum Reprod . 2004;19:435–441
  21. STAKES (Finnish IVF-statistics 1992–2001—Data Supplier Feedback 2002) . Helsinki: STAKES; 2002;
  22. Schachter M , Raziel A , Friedler S , Strassburger D , Bern O , Ron-El R . Monozygotic twinning after assisted reproductive techniques (a phenomenon independent of micromanipulation) . Hum Reprod . 2001;16:1264–1269
  23. Hemminki E , Gissler M , Toukomaa H . Exposure to female hormone drugs during pregnancy (effect on malformations and cancer) . Br J Cancer . 1999;80:1092–1097
  24. Kruse K , Lauver D , Hanson K . Clinical implications of DES . Nurse Pract . 2003;28:26–35
  25. Silver RI , Rodriquez R , Chang TSK , Gearhart JP . In vitro fertilization is associated with an increased risk of hypospadias . J Urol . 1999;161:1954–1957

 Supported by the Academy of Finland, the Ministry of Education, and the National Research and Development Centre for Welfare and Health.

PII: S0015-0282(05)02926-2

doi: 10.1016/j.fertnstert.2005.03.085

Fertility and Sterility
Volume 84, Issue 5 , Pages 1300-1307 , November 2005

Article Tools