Fertility and Sterility
Volume 84, Issue 5 , Pages 1308-1315 , November 2005

In vitro fertilization is associated with an increase in major birth defects

  • Christine K. Olson, M.D., M.P.H.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa, USA
    • ,
  • Kim M. Keppler-Noreuil, M.D.

      Affiliations

    • Iowa State Birth Defects Registry, Iowa City, Iowa, USA
    • ,
  • Paul A. Romitti, Ph.D.

      Affiliations

    • College of Public Health, University of Iowa, Iowa City, Iowa
    • ,
  • William T. Budelier

      Affiliations

    • College of Public Health, University of Iowa, Iowa City, Iowa
    • ,
  • Ginny Ryan, M.D.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa, USA
    • ,
  • Amy E.T. Sparks, Ph.D.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa, USA
    • ,
  • Bradley J. Van Voorhis, M.D.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa, USA
    • Corresponding Author InformationReprint requests: Bradley J. Van Voorhis, M.D., University of Iowa Hospitals and Clinics, Department of Obstetrics and Gynecology, 200 Hawkins Drive, Iowa City, IA 52242 (FAX: 319-353-6659).

Received 16 September 2004 ,Revised 3 March 2005 ,Accepted 3 March 2005.

References 

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  2. French In Vitro National (FIVNAT) and Instituit National de la Sante et de la Recherché Medicale U292 . Pregnancies and births resulting from in vitro fertilization (French national registry, analysis of data 1986 to 1990) . Fertil Steril . 1995;64:746–756
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  15. Moll AC , Imhof SM , Cruysberg JR , Schouten-van Meeteren AY , Boers M , van Leeuwen FE . Incidence of retinoblastoma in children born after in-vitro fertilization . Lancet . 2003;361:309–310
  16. Orstavik KH , Eiklid K , van der Hagen CB , Spetalen S , Kierulf K , Skjeldal O , et al.   Another case of imprinting defect in a girl with Angelman Syndrome who was conceived by intracytoplasmic sperm injection . Am J Hum Genet . 2003;72:218–219
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  18. Rasmussen SA , Olney RS , Holmes LB , Lin AE , Keppler-Noreuil KM , Moore CA , et al.   Guidelines for case classification for the National Birth Defects Prevention Study . Birth Defects Res A Clin Mol Teratol . 2003;67:193–201
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PII: S0015-0282(05)02929-8

doi: 10.1016/j.fertnstert.2005.03.086

Fertility and Sterility
Volume 84, Issue 5 , Pages 1308-1315 , November 2005

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