Fertility and Sterility
Volume 84, Issue 6 , Pages 1662-1664 , December 2005

Age as a limiting factor for successful sperm retrieval in patients with nonmosaic Klinefelter’s syndrome

  • Hiroshi Okada, M.D., Ph.D.

      Affiliations

    • Department of Urology, Teikyo University School of Medicine, Tokyo, Japan
    • Corresponding Author InformationReprint requests: Hiroshi Okada, M.D., Department of Urology, Teikyo University School of Medicine, 2-11-1, Kaga, Itabashi-ku, Tokyo, Japan, 173-8605 (FAX: +81-3-3964-89349).
    • ,
  • Kazumasa Goda, M.D., Ph.D.

      Affiliations

    • Division of Urology, Department of Organ Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    • ,
  • Yasuhisa Yamamoto, M.D., Ph.D.

      Affiliations

    • Department of Urology, Tottori University School of Medicine, Yonago, Japan
    • ,
  • Nikolaos Sofikitis, M.D., Ph.D.

      Affiliations

    • Molecular Urology Laboratory, Department of Urology, Ionannina University School of Medicine, Ionannina, Greece
    • ,
  • Ikuo Miyagawa, M.D., Ph.D.

      Affiliations

    • Department of Urology, Tottori University School of Medicine, Yonago, Japan
    • ,
  • Yasuyuki Mio, M.D., Ph.D.

      Affiliations

    • Mio Fertility Clinic, Yonago, Japan
    • ,
  • Mitsunobu Koshida, M.D., Ph.D.

      Affiliations

    • Koshida Clinic, Osaka, Japan
    • ,
  • Shigeo Horie, M.D., Ph.D.

      Affiliations

    • Department of Urology, Teikyo University School of Medicine, Tokyo, Japan

Received 8 December 2004 ,Revised 23 May 2005 ,Accepted 23 May 2005.

References 

  1. Okada H , Fujioka H , Tatsumi N , Kanzaki M , Okuda Y , Fujisawa M , et al.   Klinefelter’s syndrome in the male infertility clinic . Hum Reprod . 1999;14:946–952
  2. Friedler S , Raziel A , Strassburger D , Schachter M , Bern O , Ron-El R . Outcome of ICSI using fresh and cryopreserved-thawed testicular spermatozoa in patients with non-mosaic Klinefelter’s syndrome . Hum Reprod . 2001;16:2616–2620
  3. Okada H , Dobashi M , Yamazaki T , Hara I , Fujisawa M , Arakawa S , et al.   Conventional versus microdissection testicular sperm extraction for nonobstructive azoospermia . J Urol . 2002;168:1063–1067
  4. Schlegel PN . Testicular sperm extraction (microdissection improves sperm yield with minimal tissue excision) . Hum Reprod . 1999;141:131–135
  5. Tsujimura A , Matsumiya K , Miyagawa Y , Tohda A , Miura H , Nishimura K , et al.   Conventional multiple or microdissection testicular sperm extraction (a comparative study) . Hum Reprod . 2002;17:2924–2929
  6. Friedler S , Raziel A , Schachter M , Strassburger D , Bern O , Ron-El R . Outcome of first and repeated testicular sperm extraction and ICSI in patients with non-obstructive azoospermia . Hum Reprod . 2002;17:2356–2361
  7. Madgar I , Dor J , Weissenberg R , Raviv G , Menashe Y , Levron J . Prognostic value of the clinical and laboratory evaluation in patients with nonmosaic Klinefelter syndrome who are receiving assisted reproductive therapy . Fertil Steril . 2002;77:1167–1169
  8. Tournaye H , Verheyen G , Nagy P , Ubaldi F , Goossens A , Silber S , et al.   Are there any predictive factors for successful testicular sperm recovery in azoospermic patients? . Hum Reprod . 1997;12:80–86
  9. Ezeh UI , Taub NA , Moore HD , Cooke ID . Establishment of predictive variables associated with testicular sperm retrieval in men with non-obstructive azoospermia . Hum Reprod . 1999;14:1005–1012
  10. Westlander G , Ekerhovd E , Granberg S , Hanson L , Hanson C , Bergh C . Testicular ultrasonography and extended chromosome analysis in men with nonmosaic Klinefelter syndrome (a prospective study of possible predictive factors for successful sperm recovery) . Fertil Steril . 2001;75:1102–1105
  11. Vernaeve V , Staessen C , Verheyen G , Steirteghem AV , Devroey P , Tournaye H . Can biological or clinical parameters predict testicular sperm recovery in 47,XXY Klinefelter’s syndrome patients? . Hum Reprod . 2004;19:1135–1139
  12. Ballesca JL , Balasch J , Calafell JM , Alvarez R , Fabregues F , de Osaba MJ , et al.   Serum inhibin B determination is predictive of successful testicular sperm extraction in men with non-obstructive azoospermia . Hum Reprod . 2000;15:1734–1738
  13. Sniffen RC , Howard RP , Simmons FA . The testis III, absence of germ cells, sclerosing tubular degeneration; “male climacteric.” . Arch Pathol . 1951;51:293–311
  14. Gordon DL , Krmpotic E , Thomas W , Gandy HM , Paulsen CA . Pathologic testicular findings in Klinefelter’s syndrome. 47,XXY vs. 46,XY-47,XXY . Arch Intern Med . 1972;130:726–729
  15. Lanfranco F , Kamischke A , Zitzmann M , Nieschlag E . Klinefelter’s syndrome . Lancet . 2004;364:273–283
  16. Damani MN , Mittal R , Oates RD . Testicular tissue extraction in a young male with 47,XXY Klinefelter’s syndrome (potential strategy for preservation of fertility) . Fertil Steril . 2001;76:1054–1056
  17. Lin YM , Huang WJ , Lin JSN , Kuo PL . Progressive depletion of germ cells in a man with nonmosaic Klinefelter’s syndrome (optimal time for sperm recovery) . Urology . 2004;63:380–381

PII: S0015-0282(05)02940-7

doi: 10.1016/j.fertnstert.2005.05.053

Fertility and Sterility
Volume 84, Issue 6 , Pages 1662-1664 , December 2005

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