Fertility and Sterility
Volume 84, Issue 6 , Pages 1637-1642 , December 2005

Optimum number of embryos to transfer in women more than 40 years of age undergoing treatment with assisted reproductive technologies

Received 12 August 2004 ,Revised 19 April 2005 ,Accepted 19 April 2005.

References 

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  8. Janny L , Ménézo Y . Maternal age effect on early human embryonic development and blastocyst formation . Mol Reprod Dev . 1996;45:31–37
  9. Ziebe S , Loft A , Peterson J , Andersen A , Lindenberg S , Petersen K , et al.   Embryo quality and developmental potential is compromised by age . Acta Obstet Gynecol Scand . 2001;80:169–174
  10. Hassold T , Chiu D . Maternal age-specific rates of numerical chromosomal abnormalities with special reference to trisomy . Hum Genet . 1985;70:11–17
  11. Munné S , Alikani M , Tomkin G , Grifo J , Cohen J . Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities . Fertil Steril . 1995;64:382–391
  12. Svendsen T , Jones D , Butler L , Muasher S . The incidence of multiple gestations after in vitro fertilization is dependent on the number of embryos transferred and maternal age . Fertil Steril . 1996;65:561–565
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  14. Schieve L , Peterson H , Meikle S , Jeng G , Danel I , Burnett N , et al.   Live-birth rates and multiple-birth risk using in vitro fertilization . JAMA . 1999;282:1832–1838
  15. Opsahl M , Blauer K , Black S , Lincoln S , Thorsell L , Sherins R . The number of embryos available for transfer predicts successful pregnancy outcome in women over 39 years with normal ovarian hormonal reserve testing . J Assist Reprod Genet . 2001;18:551–556
  16. Racowsky C , Combelles CMH , Nureddin A , Pan Y , Finn A , Miles L , et al.   Day 3 and day 5 morphological predictors of embryo viability . Reprod Biomed Online . 2003;6:323–331
  17. Adonakis G , Camus M , Joris H , Vandervorst M , Van Steirteghem A , Devroey P . The role of the number of replaced embryos on intracytoplasmic sperm injection outcome in women over the age of 40 . Hum Reprod . 1997;12:2542–2545
  18. Magli M , Gianaroli L , Munné S , Ferraretti A . Incidence of chromosomal abnormalities from a morphologically normal cohort of embryos in poor-prognosis patients . J Assist Reprod Genet . 1998;15:297–301
  19. Sandalinas M , Sadowy S , Alikani M , Calderon J , Cohen J , Munné S . Developmental ability of chromosomally abnormal human embryos to develop to the blastocyst stage . Hum Reprod . 2001;16:1954–1958
  20. Gianaroli L , Magli MC , Ferraretti AP , Tabanelli C , Trombetta C , Boudjema E . The role of preimplantation diagnosis for aneuploidies . Reprod Biomed Online . 2002;4(Suppl 3):31–36
  21. Obasaju M , Kadam A , Biancardi T , Sultan K , Fateh M , Munné S . Pregnancies from single normal embryo transfer in women older than 40 years . Reprod Biomed Online . 2001;2:98–101

PII: S0015-0282(05)03040-2

doi: 10.1016/j.fertnstert.2005.04.070

Fertility and Sterility
Volume 84, Issue 6 , Pages 1637-1642 , December 2005

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