Fertility and Sterility
Volume 84, Issue 6 , Pages 1613-1619 , December 2005

Elective single blastocyst transfer reduces twin rates without compromising pregnancy rates

Presented at the American Society of Reproductive Medicine annual meeting, Philadelphia, Pennsylvania, October 16–20, 2004.

  • Amy Criniti, M.D.

      Affiliations

    • University of Washington Fertility and Endocrine Center, Seattle, Washington
    • Corresponding Author InformationReprint requests: Amy Criniti, M.D., Department of Obstetrics and Gynecology, University of Washington Medical Center, 1959 NE Pacific Street, Seattle, Washington 98195 (FAX: 206-543-3915).
  • ,
  • Angela Thyer, M.D.

      Affiliations

    • Seattle Reproductive Medicine, Seattle, Washington
  • ,
  • Gregory Chow, M.D.

      Affiliations

    • University of Washington Fertility and Endocrine Center, Seattle, Washington
  • ,
  • Paul Lin, M.D.

      Affiliations

    • Seattle Reproductive Medicine, Seattle, Washington
  • ,
  • Nancy Klein, M.D.

      Affiliations

    • Seattle Reproductive Medicine, Seattle, Washington
  • ,
  • Michael Soules, M.D.

      Affiliations

    • Seattle Reproductive Medicine, Seattle, Washington

Received 23 January 2005 ,Revised 10 June 2005 ,Accepted 10 June 2005.

References 

  1. Centers for Disease Control and Prevention, ASRM, Society for Assisted Reproductive Technology, Resolve . Assisted reproductive technology success rates . Atlanta, Georgia: Centers for Disease Control and Prevention; 2002;
  2. Pinborg A , Loft A , Ziebe S , Andersen A . What is the most relevant standard of success in assisted reproduction? Is there a single “parameter of excellence”? . Hum Reprod . 2004;19:1052–1054
  3. Pinborg A , Loft A , Schmidt L , Andersen AN . Morbidity in a Danish national cohort of 472 IVF/ICSI twins, 1132 nonIVF/ICSI twins and 634 IVF/ICSI singletons (health related and social implications for the children and their families) . Hum Reprod . 2003;18:1234–1243
  4. Kogan MD , Alexander GR , Kotelchuck M , MacDorman MF , Buekens P , Martin JA , et al.   Trends in twin birth outcomes and prenatal care utilization in the United States, 1981–1997 . JAMA . 2000;19:284:335–341
  5. Scher AI , Petterson B , Blair E , Ellenberg JH , Grether JK , Haan E , et al.   The risk of mortality or cerebral palsy in twins (a collaborative population-based study) . Pediatr Res . 2002;52:671–681
  6. Rutter M , Thorpe K , Greenwood R , Northstone K , Golding J . Twins as a natural experiment to study the causes of mild language delay: I: design, twin-singleton differences in language, and obstetrics risks . J Child Psychol Psychiatry . 2003;44:326–341
  7. Griesinger G , Dafopoulos K , Schultze-Mosgau A , Felberbaum R , Diedrich K . What is the most relevant standard of success in assisted reproduction? Is BESST (birth emphasizing a successful singleton at term) truly the best? . Hum Reprod . 2004;19:1239–1241
  8. Glazebrook C , Sheard C , Cox S , Oates M , Ndukwe G . Parenting stress in first-time mothers of twins and triplets conceived after in vitro fertilization . Fertil Steril . 2004;81:505–511
  9. ESHRE Campus Course Report. Prevention of twin pregnancies after IVF/ICSI by single embryo transfer . Hum Reprod . 2001;16:790–800
  10. Gardner DK , Schoolcraft WB . In-vitro culture of human blastocysts . In:  Jansen R editors. Towards reproductive certainty (fertility and genetics beyond 1999) . Carnforth (UK): Parthenon Press; 1999;
  11. Menezo YJ . Blastocyst freezing . Eur J Obstet Gynecol Reprod Biol . 2004;115:12–15
  12. Gerris J , De Neubourg D , Mangelschots K , Van Royen E , Van de Meerssche M , Valkenburg M . Prevention of twin pregnancy after in-vitro fertilization or intracytoplasmic sperm injection based on strict embryo criteria (a prospective randomized clinical trial) . Hum Reprod . 1999;14:2581–2587
  13. Gerris J , De Neubourg D , Mangelschots K , Van Royen E , Vercruyssen M , Barudy-Vasquez J , et al.   Elective single day 3 embryo transfer halves the twinning rate without decrease in the ongoing pregnancy rate of an IVF/ICSI programme . Hum Reprod . 2002;17:2626–2631
  14. Vilska S , Tiitinen A , Hyden-Granskog C , Hovatta O . Elective transfer of one embryo results in an acceptable pregnancy rate and eliminates the risk of multiple birth . Hum Reprod . 1999;14:2392–2395
  15. Martikainen H , Tiitinen A , Candido T , Tomas C , Tapanainen J , Orava M , et al.   One versus two embryo transfer after IVF and ICSI (a randomized study) . Hum Reprod . 2001;16:1900–1903
  16. Tiitinen A , Unkila-Kallio L , Halttunen M , Hyden-Granskog C . Impact of elective single embryo transfer on the twin pregnancy rate . Hum Reprod . 2003;18:1449–1453
  17. Gardner DK , Surrey E , Minjarez D , Leitz A , Stevens J , Schoolcraft WB . Single blastocyst transfer (a prospective randomized trial) . Fertil Steril . 2004;81:551–554
  18. Milki A , Jun S , Hinckley M , Behr B , Giudice L , Westphal L . Incidence of monozygotic twinning with blastocyst transfer compared to cleavage-stage transfer . Fertil Steril . 2003;79:503–506
  19. Gardner DK , Schoolcraft WB , Wagley L , Schlenker T , Stevens J , Hesla J . A prospective randomized trial of blastocyst culture and transfer in in-vitro fertilization . Hum Reprod . 1998;13:3434–3440
  20. Coskun S , Hollanders J , Al Hassan S , Al Sufyan H , Al Mayman H , Jaroudi K . Day 5 versus day 3 embryo transfer (a controlled randomized trial) . Hum Reprod . 2000;15:1947–1952
  21. Karaki RZ , Samarraie SS , Younis NA , Lahloub TM , Ibrahim MH . Blastocyst culture and transfer (a step toward improved in vitro fertilization outcome) . Fertil Steril . 2002;77:114–118
  22. Levron J , Schulman A , Bider D , Seidman D , Levin T , Dor J . A prospective randomized study comparing day 3 with blastocyst-stage embryo transfer . Fertil Steril . 2002;77:1300–1301
  23. Utsunomiya T , Naitou T , Nagaki M . A prospective trial of blastocyst culture and transfer . Hum Reprod . 2002;17:1846–1851
  24. Rienzi L , Ubaldi F , Iacobeli M , Ferrero S , Minasi MG , Martinez F , et al.   Day 3 embryo transfer with combined evaluation at the pronuclear and cleavage stages compares favorably with day 5 blastocyst transfer . Hum Reprod . 2002;17:1852–1855
  25. Van der Auwera I , Debrock S , Spiessens C , Afschrift H , Bakelants E , Meuleman C , et al.   A prospective randomized study (day 2 versus day 5 embryo transfer) . Hum Reprod . 2002;17:1507–1512
  26. Frattarelli JL , Leondires M , McKeeby JL , Miller BT , Segars JH . Blastocyst transfer decreases multiple pregnancy rates in in vitro fertilization cycles (a randomized controlled trial) . Fertil Steril . 2003;79:228–230
  27. Margreiter M , Weghofer A , Kogosowski A , Mahmoud KZ , Feichtinger W . A prospective randomised multicenter study to evaluate the best day for embryo transfer (does the outcome justify prolonged embryo culture?) . J Assist Reprod Genet . 2003;20:91–93
  28. Behr B , Fisch JD , Racowski C , Miller K , Pool TB , Milki AA . Blastocyst-ET and monozygotic twinning . J Assist Reprod Genet . 2000;17:349–351
  29. Gardner DK , Vella P , Lane M , Wagley L , Schlenker T , Schoolcraft WB . Culture and transfer of human blastocysts increase implantation rates and reduces the need for multiple embryo transfers . Fertil Steril . 1998;69:84–88
  30. Behr B , Pool TB , Milki A , Moore D , Gebhardt J , Dasig D . Preliminary clinical experience with human blastocyst development in vitro without co-culture . Hum Reprod . 1999;14:454–457
  31. Ryan G , Zhang S , Dokras A , Syrop C , Van Voorhis B . The desire of infertile patients for multiple births . Fertil Steril . 2004;81:500–504
  32. Murray S , Shetty A , Rattray A , Taylor V , Bhattacharya S . A randomized comparison of alternative methods of information provision on the acceptability of elective single embryo transfer . Hum Reprod . 2004;19:911–916

PII: S0015-0282(05)03331-5

doi: 10.1016/j.fertnstert.2005.06.035

Fertility and Sterility
Volume 84, Issue 6 , Pages 1613-1619 , December 2005