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Fertility and Sterility
Volume 84, Issue 6
, Pages 1589-1601
, December 2005
A critique of the Women’s Health Initiative hormone therapy study
References
- . Risks and benefits of estrogen plus progestin in healthy postmenopausal women (principal results from the Women’s Health Initiative randomized controlled trial) . JAMA . 2002;288:321–333
- . Effects of conjugated equine estrogen in postmenopausal women with hysterectomy (the Women’s Health Initiative randomized controlled trial) . JAMA . 2004;291:1701–1712
-
.
Deaths, percent of total deaths, and death rates for the 10 leading causes of death in selected age groups, by race and sex
(United States, 2000–Con)
.
National Vital Statistics Report
. 2002;50:1–85
- . A prospective study of postmenopausal estrogen therapy and coronary heart disease . N Engl J Med . 1985;313:1044–1049
- Comparison of electrocardiography and thallium-201 myocardial scintigraphy for the detection of ergonovine-induced coronary artery spasm (angiographic correlation) . Am Heart J . 1987;113:663–671
- . Correlation of vectorcardiogram and electrocardiogram with coronary arteriogram . Circulation . 1968;38:189–200
- Are electrocardiographic Q-wave criteria reliable for diagnosis of perioperative myocardial infarction after coronary surgery? . Eur J Cardiothorac Surg . 1998;13:655–661
- Reliability of the exercise ECG in detecting silent ischemia in patients with prior myocardial infarction . Kaku Igaku . 1991;28:261–269
- Coronary artery calcification detected with ultrafast CT as an indication of coronary artery disease . Radiology . 1992;185:435–439
- . Detection of calcific deposits in coronary arteries by ultrafast computed tomography and correlation with angiography . Am J Cardiol . 1989;63:870–872
-
Identification of patients at increased risk of first unheralded acute myocardial infarction by electron-beam computed tomography
.
Circulation
. 2000;101:850–855
- Synergistic action of severe wall injury and shear forces on thrombus formation in arterial stenosis (definition of a thrombotic shear rate threshold) . J Am Coll Cardiol . 1994;24:1091–1097
- Reduced effect of aspirin on thrombus formation at high shear and disturbed laminar blood flow . Thromb Haemost . 1996;75:827–832
- . Effects of low and high dose oral contraceptives on blood coagulation and thrombogenesis induced by vascular subendothelium exposed to flowing human blood . Contraception . 1991;43:435–446
- Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women . Thromb Haemost . 2001;85:619–625
- Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women . [see comments] JAMA . 1998;280:605–613
-
.
Critique of the Report from the Writing Group of the WHI
.
Menopausal Med
. 2003;10:1–4
-
.
Considerations in interpreting the cardiovascular effects of hormone replacement therapy observed in the WHI
(timing is everything)
.
Menopausal Med
. 2003;10:8–12
- . The relevance of the Women’s Health Initiative results on combined hormone replacement therapy in clinical practice . J Obstet Gynaecol Can . 2002;24:711–715
- Estrogen replacement and brachial artery flow-mediated vasodilation in older women . Arterioscler Thromb Vasc Biol . 2001;21:1955–1961
- Estrogen in the prevention of atherosclerosis. A randomized, double-blind, placebo-controlled trial . Ann Intern Med . 2001;135:939–953
- . Estrogen replacement therapy, atherosclerosis, and vascular function . Cardiovasc Res . 2002;53:605–619
- . Prevalence of climacteric symptoms according to years after menopause . J Med Assoc Thai . 2001;84:1681–1691
- . Prevalence of estrogen or estrogen–progestin hormone therapy use . Obstet Gynecol . 2003;102:1240–1249
- . Evaluation of cardiovascular event rates with hormone therapy in healthy, early postmenopausal women (results from 2 large clinical trials) . Arch Intern Med . 2004;164:482–484
- The Women’s Health Initiative could not have detected cardioprotective effects of starting hormone therapy during the menopausal transition . Fertil Steril . 2004;81:1498–1501
-
.
WHI Response to Goodman, Goldzieher and Ayala’s critique of the Women’s Health Initiative Report on the risks and benefits of estrogen plus progestin
.
Menopausal Med
. 2003;11:1–3
-
.
The time has come to stop letting the HERS tale wag the dogma
.
Circulation
. 2001;104:2256–2259
- . Estrogen replacement therapy and coronary heart disease (a quantitative assessment of the epidemiologic evidence) . Prev Med . 1991;20:47–63
- . Hormonal replacement therapy and morbidity and mortality in a prospective study of postmenopausal women . Am J Public Health . 1995;85:1128–1132
- Postmenopausal estrogen and progestin use and the risk of cardiovascular disease . N Engl J Med . 1996;335:453–461
- . A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease . Ann Intern Med . 2000;133:933–941
- . Postmenopausal oestrogen treatment and stroke (a prospective study) . BMJ . 1988;297:519–522
- . Estrogen replacement therapy and stroke . Prog Cardiovasc Dis . 1995;38:223–242
- . Mortality in a cohort of long-term users of hormone replacement therapy (an updated analysis) . Br J Obstet Gynaecol . 1990;97:1080–1086
- . Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins . N Engl J Med . 1991;325:1196–1204
- . Prevention of atherosclerosis by estrogen substitution? . Geburtshilfe Frauenheilkd . 1988;48:747–756
- Cardiovascular mortality and noncontraceptive use of estrogen in women (results from the Lipid Research Clinics Program Follow-up Study) . Circulation . 1987;75:1102–1109
- . Effect of postmenopausal hormone replacement on atherosclerosis in femoral arteries . Maturitas . 2002;41:51–60
- . Estrogen status correlates with the calcium content of coronary atherosclerotic plaques in women . J Clin Endocrinol Metab . 2002;87:1062–1067
- . Atherosclerosis imaging methods (assessing cardiovascular disease and evaluating the role of estrogen in the prevention of atherosclerosis) . Am J Cardiol . 2002;89:19E–27E
- . Estrogen replacement therapy and coronary heart disease (a quantitative assessment of the epidemiologic evidence) . Prev Med . 1991;20:47–63
- . Understanding the divergent data on postmenopausal hormone therapy . N Engl J Med . 2003;348:645–650
- . Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial . JAMA . 1995;273:199–208
- . Estrogen, progestogens and cardiovascular risk . J Reprod Med . 1999;44:221–226
- . Progestins and cardiovascular risk markers . Steroids . 2000;65:651–658
- . Effects of post-menopausal oestrogen–progestogen replacement therapy on serum lipids and lipoproteins (a review) . Maturitas . 1990;12:259–285
- Effects of long-term administration of high doses of medroxyprogesterone acetate on hormone receptors and target organs in the female rat . J Endocrinol . 1984;103:287–293
- . Changes in the binding of oestradiol to uterine oestrogen receptors induced by some progesterone and 19-nor-testosterone derivatives . J Endocrinol . 1983;98:385–389
- . Cytoplasmic and nuclear estradiol and progesterone receptors in human endometrium . J Clin Endocrinol Metab . 1978;46:635–648
- . Facilitation and inhibition of the estrogen-induced luteinizing hormone surge in the rat by progesterone (effects on cytoplasmic and nuclear estrogen receptors in the hypothalamus-preoptic area, pituitary, and uterus) . Endocrinology . 1981;108:1487–1496
- . Estrogen and progesterone interactions on the estrogen receptor and thymidine kinase in the immature rat uterus . Nippon Sanka Fujinka Gakkai Zasshi . 1982;34:2172–2176
- . Effect of medroxyprogesterone acetate contraception on cytoplasmic estrogen receptor content of the human cervix uteri . Int J Fertil . 1978;23:51–56
- . Impact of progestins on estradiol potentiation of the glutamate calcium response . Neuroreport . 2002;13:825–830
- . Effects of progestins in different hormone replacement therapy formulations on estrogen-induced lipid changes in postmenopausal women . Am J Cardiol . 2002;89:47E–55E
- . A review of postmenopausal hormone therapy recommendations (potential for selection bias) . Obstet Gynecol . 1993;82:1021–1028
- . Uncertainty about postmenopausal estrogen. Time for action, not debate . N Engl J Med . 1991;325:800–802
- . Impact of the menopause on the epidemiology and risk factors of coronary artery heart disease in women . Exp Gerontol . 1994;29:357–375
- . Time trends in the HERS secondary prevention trial (much ado about nothing?) . J Am Med Womens Assoc . 2002;57:215–216
- . Design of the Women’s Health Initiative clinical trial and observational study . Control Clin Trials . 1998;19:61–109
- Hormone therapy to prevent disease and prolong life in postmenopausal women . Ann Intern Med . 1992;117:1016–1037
- . Decreased mortality in users of estrogen replacement therapy . Arch Intern Med . 1991;151:75–78
- Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the Nurses’ Health Study . N Engl J Med . 1991;325:756–762
- . Reduced mortality associated with long-term postmenopausal estrogen therapy . Obstet Gynecol . 1996;87:6–12
- . MPA and postmenopausal coronary artery atherosclerosis revisited . Steroids . 2003;68:941–951
- A review of the association of estrogens and progestins with cardiovascular disease in postmenopausal women . Arch Intern Med . 1993;153:1421–1427
- . Serum high density lipoprotein cholesterol levels in women using a contraceptive injection of depot-medroxyprogesterone acetate . Contraception . 1980;22:359–367
- . Medroxyprogesterone interferes with ovarian steroid protection against coronary vasospasm . Nat Med . 1997;3:324–327
- . Medroxyprogesterone attenuates estrogen-mediated inhibition of neointima formation after balloon injury of the rat carotid artery . Circulation . 1996;94:2221–2227
- . Conjugated equine estrogens alone, but not in combination with medroxyprogesterone acetate, inhibit aortic connective tissue remodeling after plasma lipid lowering in female monkeys . Arterioscler Thromb Vasc Biol . 1998;18:1164–1171
- . Progestogens and cardiovascular disease. A critical review . J Reprod Med . 1999;44:180–184
- . Medroxyprogesterone acetate antagonizes inhibitory effects of conjugated equine estrogens on coronary artery atherosclerosis . Arterioscler Thromb Vasc Biol . 1997;17:217–221
- . A comparison of tibolone and conjugated equine estrogens effects on coronary artery atherosclerosis and bone density of postmenopausal monkeys . J Clin Endocrinol Metab . 2001;86:5396–5404
- . Clinical and metabolic responses of menopausal women to sequential versus continuous estrogen and progestin replacement therapy . Obstet Gynecol . 1998;71:39–43
- Inhibition of coronary artery atherosclerosis by 17-beta estradiol in ovariectomized monkeys. Lack of an effect of added progesterone . Arteriosclerosis . 1990;10:1051–1057
- Hormone therapy and the progression of coronary-artery athersclerosis in postmenopausal women . N Engl J Med . 2003;349:535–545
- Effects of estrogen replacement on the progression of coronary-artery atherosclerosis . N Engl J Med . 2000;343:522–529
- . Common carotid intima–media thickness is correlated with myocardial flow reserve in patients with coronary artery disease (a useful non-invasive indicator of coronary atherosclerosis) . Int J Cardiol . 2004;93:131–136
- Effect of estrogen plus progestin on progression of carotid atherosclerosis in postmenopausal women with heart disease (HERS B-mode substudy) . Arterioscler Thromb Vasc Biol . 2002;22:1692–1697
- Estrogen plus progestin and the risk of coronary heart disease . N Engl J Med . 2003;349:523–534
-
.
WHI study
(one year later)
.
[letter]
San Francisco Med
. 2003;19–21
- . Effects of hormone replacement therapy on the mammary gland of surgically postmenopausal cynomolgus macaques . Am J Obstet Gynecol . 1996;174:93–100
- . Progestins and menopause (epidemiological studies of risks of endometrial and breast cancer) . Steroids . 2000;65:659–664
- . Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk . [see comments] JAMA . 2000;283:485–491
- . Prospective study of estrogen replacement therapy and risk of breast cancer in postmenopausal women . JAMA . 1990;264:2648–2653
- . Breast cancer risk after estrogen replacement therapy (results from the Toronto Breast Cancer Study) . Am J Epidemiol . 1991;134:1386–1401
- . Breast cancer and hormone replacement therapy (collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer) . Lancet . 1997;350:1047–1059
- Hormone replacement therapy regimens and breast cancer risk . Obstet Gynecol . 2002;100:1148–1158
- . Effect of hormone replacement therapy on breast cancer risk (estrogen versus estrogen plus progestin) . J Natl Cancer Inst . 2000;92:328–332
- . Breast cancer and hormone-replacement therapy in the Million Women Study . Lancet . 2003;362:419–427
- Postmenopausal hormone therapy and mortality . [see comments] N Engl J Med . 1997;336:1769–1775
- . The impact of hormone replacement therapy on the detection and stage of breast cancer . Arch Surg . 2002;137:1015–1021
- . The Million Women Study and breast cancer . Maturitas . 2003;46:1–6
-
.
Assess your true risk of breast cancer
. New York: Henry Holt; 2000;
- Relationships of serum estradiol levels, menopausal duration, and mood during hormonal replacement therapy . Psychoneuroendocrinology . 1997;22:549–558
-
.
Hormones and the mind
(a woman’s guide to enhancing mood, memory, and sexual vitality)
. New York: HarperCollins; 2001;
- . Failure of estrogen plus progestin therapy for prevention . JAMA . 2002;288:366–368
- . Preserving cardiovascular benefits of hormone replacement therapy . J Reprod Med . 2000;45(3 Suppl):259–273
- . Estrogen and progesterone replacement therapy reduces low density lipoprotein accumulation in the coronary arteries of surgically postmenopausal cynomolgus monkeys . J Clin Invest . 1991;88:1995–2002
- . Hormone replacement therapy of menopause, heart and blood vessels . Arch Mal Coeur Vaiss . 2001;94:685–689
- Natural progesterone, but not medroxyprogesterone acetate, enhances the beneficial effect of estrogen on exercise-induced myocardial ischemia in postmenopausal women . J Am Coll Cardiol . 2000;36:2154–2159
- Effect of transdermal estradiol and oral conjugated estrogen on C-reactive protein in retinoid-placebo trial in healthy women . Circulation . 2002;106:1224–1228
- Effects of transdermal and oral oestrogen replacement therapy on C-reactive protein levels in postmenopausal women (a randomised, placebo-controlled trial) . Thromb Haemost . 2002;88:605–610
- . Differential effects of oral versus transdermal estrogen replacement therapy on C-reactive protein in postmenopausal women . J Am Coll Cardiol . 2003;41:1358–1363
- Differential effects of oral and transdermal postmenopausal estrogen replacement therapies on C-reactive protein . Thromb Haemost . 2003;90:124–131
- Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease (prospective analysis from the Women’s Health Initiative observational study) . JAMA . 2002;288:980–987
- . Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk . Lancet . 2003;362:428–432
-
.
Hormone replacement therapy
(standardized or individually adapter doses?)
. New York: Parthenon Publishing Group; 1994;
- . The menopause and osteoporosis . Obstet Gynecol . 1996;87:16S–19S
PII: S0015-0282(05)03422-9
doi: 10.1016/j.fertnstert.2005.08.010
© 2005 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Fertility and Sterility
Volume 84, Issue 6
, Pages 1589-1601
, December 2005

