Fertility and Sterility
Volume 85, Issue 1 , Pages 22-29 , January 2006

Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids

An abstract of this work was presented at the Annual Clinical Meeting of the American College of Obstetricians and Gynecologists, which was held in Philadelphia, Pennsylvania, in May 2004.

  • Elizabeth A. Stewart, M.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts
    • Corresponding Author InformationReprint requests: Elizabeth A. Stewart, M.D., Center for Uterine Fibroids, Brigham and Women’s Hospital, 75 Francis Street, Boston, Massachusetts 02115 (FAX: 617-566-7752)
  • ,
  • Jaron Rabinovici, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel
  • ,
  • Clare M.C. Tempany, M.D.

      Affiliations

    • Department of Radiology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts
  • ,
  • Yael Inbar, M.D.

      Affiliations

    • Radiology, Sheba Medical Center, Tel-Hashomer, Israel
  • ,
  • Leslie Regan, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, St. Mary’s Hospital, London, United Kingdom
  • ,
  • Bobbie Gastout, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA
  • ,
  • Gina Hesley, M.D.

      Affiliations

    • Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA
  • ,
  • Hyun S. Kim, M.D.

      Affiliations

    • Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
  • ,
  • Suzanne Hengst, M.D.

      Affiliations

    • Department of Radiology, Charité Medical Center and Humboldt University, Berlin, Germany
  • ,
  • Wladyslaw M. Gedroye, M.D.

      Affiliations

    • Department of Radiology, St. Mary’s Hospital, London, United Kingdom

Received 7 January 2005 ,Revised 15 April 2005 ,Accepted 15 April 2005.

References 

  1. Stewart EA . Uterine fibroids . Lancet . 2001;357:293–298
  2. Carlson KJ , Nichols DH , Schiff I . Indications for hysterectomy . N Engl J Med . 1993;328:856–860
  3. Zhao SZ , Wong JM , Arguelles LM . Hospitalization costs associated with leiomyoma . Clin Ther . 1999;21:563–575
  4. Cote I , Jacobs P , Cumming D . Work loss associated with increased menstrual loss in the United States . Obstet Gynecol . 2002;100:683–687
  5. American College of Obstetricians and Gynecologists . Surgical alternatives to hysterectomy in the management of leiomyomas . 2000;
  6. Spies JB , Spector A , Roth AR , Baker CM , Mauro L , Murphy-Skrynarz K . Complications after uterine artery embolization for leiomyomas . Obstet Gynecol . 2002;100:873–880
  7. Pron G , Bennett J , Common A , Wall J , Asch M , Sniderman K . The Ontario Uterine Fibroid Embolization Trial. Part 2. Uterine fibroid reduction and symptom relief after uterine artery embolization for fibroids . Fertil Steril . 2003;79:120–127
  8. Goldfarb HA . Bipolar laparoscopic needles for myoma coagulation . J Am Assoc Gynecol Laparoscop . 1995;2:175–179
  9. Zreik TG , Rutherford TJ , Palter SF , Troiano RN , Williams E , Brown JM , et al.   Cryomyolysis, a new procedure for the conservative treatment of uterine fibroids . J Am Assoc Gynecol Laparoscop . 1998;5:33–38
  10. Law P , Gedroyc WM , Regan L . Magnetic-resonance-guided percutaneous laser ablation of uterine fibroids . [letter] Lancet . 1999;354:2049–2050
  11. Cowan BD , Sewell PE , Howard JC , Arriola RM , Robinette LG . Interventional magnetic resonance imaging cryotherapy of uterine fibroid tumors (preliminary observation) . Am J Obstet Gynecol . 2002;186:1183–1187
  12. Hindey J , Law P , Hickey M , Smith S , Lamping D , Gedroyc W , et al.   Clinical outcomes following percutaneous magnetic resonance image guided laser ablation of symptomatic uterine fibroids . Hum Reprod . 2002;17:2737–2741
  13. Lynn JG , Zwemer RL , Chick AJ , Miller AE . A new method for the generation and use of focused ultrasound in experimental biology . J Gen Physiol . 1942;26:179–183
  14. Hill CR , ter Haar GR . Review article (high intensity focused ultrasound—potential for cancer treatment) . Br J Radiol . 1995;68:1296–1303
  15. Rowland IJ , Rivens I , Chen L , Lebozer CH , Collins DJ , ter Haar GR , et al.   MRI study of hepatic tumours following high intensity focused ultrasound surgery . Br J Radiol . 1997;70:144–153
  16. Gelet A , Chapelon JY , Bouvier R , Pangaud C , Lasne Y . Local control of prostate cancer by transrectal high intensity focused ultrasound therapy (preliminary results) . J Urol . 1999;161:156–162
  17. Hynynen K , Pomeroy O , Smith DN , Huber PE , McDannold NJ , Kettenbach J , et al.   MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast (a feasibility study) . Radiology . 2001;219:176–185
  18. Huber PE , Jenne JW , Rastert R , Simiantonakis I , Sinn HP , Strittmatter HJ , et al.   A new noninvasive approach in breast cancer therapy using magnetic resonance imaging–guided focused ultrasound surgery . Cancer Res . 2001;61:8441–8447
  19. Tempany CM , Stewart EA , McDannold N , Quade BJ , Jolesz FA , Hynynen K . MR imaging-guided focused ultrasound surgery of uterine leiomyomas (a feasibility study) . Radiology . 2003;226:897–905
  20. Stewart EA , Gedroyc WM , Tempany CM , Quade BJ , Inbar Y , Ehrenstein T , et al.   Focused ultrasound treatment of uterine fibroid tumors (safety and feasibility of a noninvasive thermoablative technique) . Am J Obstet Gynecol . 2003;189:48–54
  21. Ishihara Y , Calderon A , Watanabe H , Okamoto K , Suzuki Y , Kuroda K . A precise and fast temperature mapping using water proton chemical shift . Magn Reson Med . 1995;34:814–823
  22. Hindley J , Gedroyc WM , Regan L , Stewart E , Tempany C , Hynnen K , et al.   MRI guidance of focused ultrasound therapy of uterine fibroids (early results) . Am J Roentgenol . 2004;183:1713–1719
  23. Tempany CM , Stewart EA , McDannold NJ , Quade BJ , Jolesz FA , Hynynen KH . MR imaging–guided focused ultrasound surgery of leiomyoma of the uterus (early experience) . Radiology . 2001;221:357–358
  24. Spies JB , Coyne K , Guaou N , Boyle D , Skyrnarz-Murphy K , Gonzalves SM . The UFS-QOL, a new disease-specific symptom and health-related quality of life questionnaire for leiomyomata . Obstet Gynecol . 2002;99:290–300
  25. Spies JB , Warren EH , Mathias SD , Walsh SM , Roth AR , Pentecost MJ . Uterine fibroid embolization (measurement of health-related quality of life before and after therapy) . J Vasc Interv Radiol . 1999;10:1293–1303
  26. Dicker RC , Greenspan JR , Strauss LT , Cowart MR , Scally MJ , Peterson HB , et al.   Complications of abdominal and vaginal hysterectomy among women of reproductive age in the United States. The Collaborative Review of Sterilization . Am J Obstet Gynecol . 1982;144:841–848
  27. Gurtcheff SE , Sharp HT . Complications associated with global endometrial ablation (the utility of the MAUDE database) . Obstet Gynecol . 2003;102:1278–1282
  28. Buttram VC , Reiter RC . Uterine leiomyomata (etiology, symptomatology, and management) . Fertil Steril . 1981;36:433–445
  29. Stewart EA , Faur AV , Wise LA , Reilly RJ , Harlow BL . Predictors of subsequent surgery for uterine leiomyomata after abdominal myomectomy . Obstet Gynecol . 2002;99:426–432
  30. Stewart EA , Nowak RA . Leiomyoma-related bleeding (a classic hypothesis updated for the molecular era) . Hum Reprod Update . 1996;2:295–306
  31. Spies JB , Roth AR , Jha RC , Gomez-Jorge J , Levy EB , Chang TC , et al.   Leiomyomata treated with uterine artery embolization (factors associated with successful symptom and imaging outcome) . Radiology . 2002;222:45–52
  32. Pron G , Mocarski E , Bennett J , Vilos G , Common A , Zaidi M , et al.   Tolerance, hospital stay, and recovery after uterine artery embolization for fibroids (the Ontario Uterine Fibroid Embolization Trial) . J Vasc Interv Radiol . 2003;14:1243–1250

 Supported and funded by Insightec, Ltd., Haifa, Israel.The following individuals also contributed to this work: Michael A. Jacobs, Ph.D., Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland; Jonathan Hindley, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel; Simcha Yagel, M.D., Department of Obstetrics and Gynecology, Hadassah Medical Center, Jerusalem, Israel; Tilman Ehrenstein, M.D., and Miri Sklair Levy, M.D., Department of Radiology, Charité Medical Center and Humboldt University, Berlin, Germany; and Ferenc A. Jolesz, M.D., Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts.

PII: S0015-0282(05)03655-1

doi: 10.1016/j.fertnstert.2005.04.072

Fertility and Sterility
Volume 85, Issue 1 , Pages 22-29 , January 2006