Fertility and Sterility
Volume 85 , Pages 1265-1275 , April 2006

Increased expression of interleukin-1α and interleukin-1β is associated with experimental varicocele

  • Zeliha Sahin, M.Sc.

      Affiliations

    • Department of Histology and Embryology, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    • ,
  • Ciler Celik-Ozenci, Ph.D.

      Affiliations

    • Department of Histology and Embryology, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    • ,
  • Gokhan Akkoyunlu, Ph.D.

      Affiliations

    • Department of Histology and Embryology, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    • ,
  • Emin Turkay Korgun, Ph.D.

      Affiliations

    • Department of Histology and Embryology, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    • ,
  • Nuray Acar, M.Sc.

      Affiliations

    • Department of Histology and Embryology, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    • ,
  • Tibet Erdogru, M.D.

      Affiliations

    • Department of Urology, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    • ,
  • Ramazan Demir, Ph.D.

      Affiliations

    • Department of Histology and Embryology, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    • ,
  • Ismail Ustunel, Ph.D.

      Affiliations

    • Department of Histology and Embryology, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    • Corresponding Author InformationReprint requests: Ismail Ustunel, Ph.D., Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, 07070, Antalya, Turkey (FAX: +90-242-2274486)

Received 18 July 2005 ,Revised 26 October 2005 ,Accepted 26 October 2005.

References 

  1. Jarow JP . Effect of varicocele on male fertility . Hum Reprod Update . 2001;7:59–64
  2. Sahin Z , Bayram Z , Celik-Ozenci C , Akkoyunlu G , Seval Y , Erdogru T , et al.   Effect of experimental varicocele on the expressions of notch 1, 2 and 3 in rat testes (an immunohistochemical study) . Fertil Steril . 2005;83:86–94
  3. Celik-Ozenci C , Sahin Z , Ustunel I , Akkoyunlu G , Erdogru T , Korgun ET , et al.   The Fas system may have a role in male reproduction . Fertil Steril . 2006;85:1168–1178
  4. Callard R , George AJT , Stark J . Cytokines, chaos, and complexity . Immunity . 1999;11:507–513
  5. Cavaillon JM . Interleukine-1 . In:  Cavaillon JM editors. Les cytokines . 2nd ed.. Paris: Masson; 1996;p. 93–117 French
  6. Sims JE , Dawer SK . Interleukin-1 receptors . Eur Cytokine Netw . 1994;5/6:539–546
  7. Huleihel M , Lunenfeld E , Horowitz S , Levy A , Potashnik G , Glezerman M . Production of interleukin-1–like molecules by human sperm cells . Fertil Steril . 2000;73:1132–1137
  8. Khan S , Soder O , Syed V , Gustafson K , Lindh M , Litzen EM . The rat testis produces large amounts of interleukin 1–like factor . Int J Androl . 1987;10:494–503
  9. Gerard N , Syed V , Bardin W , Genetet N , Jegou B . Sertoli cells are the site of interleukin-1 alpha synthesis in rat testis . Mol Cell Endocrinol . 1991;82:R13–R16
  10. Gow R , O’Bryan MK , Canny BJ , Ooi GT , Hedger MP . Differential effects of dexamethasone treatment on lipopolysaccharide-induced testicular inflammation and reproductive hormone inhibition in adult rats . J Endocrinol . 2001;168:193–201
  11. Gerard N , Syed V , Je’gou B . Lipopolysaccharide, latex beads and residual bodies are potent activators of Sertoli cell interleukin-1a production . Biochem Biophys Res Commun . 1992;185:154–161
  12. Buch JP , Kolon TF , Maulik N , Kreutzer DL , Das DK . Cytokines stimulate lipid membrane peroxidation of human sperm . Fertil Steril . 1994;62:186–188
  13. Hedger MP , Meinhardt A . Cytokines and the immune-testicular axis . J Reprod Immunol . 2003;58:1–26
  14. Chen LP , Wang SQ , Zhao YZ , Liu L , Wang SX , Lu YZ . The changes of IL-1 and NO levels in the testes of rats with experimental varicocele . Zhonghua Nan Ke Xue . 2002;8:125–126
  15. Hahn D, Blaschitz A, Korgun ET, Lang I, Desoye G, Skofitsch G, et al. From maternal glucose to fetal glycogen (expression of key regulators in the human placenta) . Mol Hum Reprod . 2001;7:1173–1178
  16. Lowry OH , Rosebrough NJ , Farr AL , Randall RJ . Protein measurement with the Folin phenol reagent . J Biol Chem . 1951;193:265–275
  17. Harrison RM , Lewis RW , Roberts JA . Pathophysiology of varicocele in the nonhuman primates (long-term survival and testicular changes) . Fertil Steril . 1986;46:500–510
  18. Lipshultz LI , Corriere JN . Progressive testicular atrophy in the varicocele patient . J Urol . 1997;17:175–176
  19. Baggiolin M , Dewald B , Moser B . Human chemokines (an update) . Ann Rev Immunol . 1997;15:675–700
  20. Khan SA , Khan SJ , Dorrington JH . Interleukin-1 stimulates deoxyribonucleic acid synthesis in immature rat Leydig cells in vitro . Endocrinology . 1992;131:1853–1857
  21. Jegou B , Cudicini C , Gomez E , Stephan JP . Interleukin-1, interleukin- 6 and the germ cell-Sertoli cell cross-talk . Reprod Fertil Dev . 1995;7:723–730
  22. Dousset B , Hussenet F , Daudin M , Bujan L , Foliguet B , Nabet P . Seminal cytokine concentrations (IL-1beta, IL-2, IL-6, sR IL-2, sR IL-6), semen parameters and blood hormonal status in male infertility . Hum Reprod . 1997;12:1476–1479
  23. Lin T , Guo H , Calkins JH , Wang D , Chi R . Recombinant monocyte-derived interleukin-1 receptor antagonist reverses inhibitory effects of interleukin-1 on Leydig cell steroidogenesis . Mol cell endocrinol . 1991;78:205–209
  24. Mauduit C , Chauvin MA , Hartmann DJ . Interleukin-1a as a potent inhibitor of gonadotropin action in porcine Leydig cells (sites of action) . Biol Reprod . 1992;46:1119–1126
  25. Verhoeven G , Cailleau J , Damme JV , Billiau A . Interleukin-1 stimulates steroidogenesis in cultured rat Leydig cells . Mol Cell Endocrinol . 1988;57:51–60
  26. Stylianou E , Saklatvala J . Interleukin-1 . Int J Biochem Cell Biol . 2000;30:1075–1079
  27. Sultana T , Svechnikov K , Weber G , Soder O . Molecular cloning and expression of a functionally different alternative splice variant of prointerleukin-1alpha from the rat testis . Endocrinology . 2000;141:4413–4418

 This study was supported by Akdeniz University Research Foundation Antalya, Turkey, project number 2002.02.0122.003.

PII: S0015-0282(05)04201-9

doi: 10.1016/j.fertnstert.2005.10.025

Fertility and Sterility
Volume 85 , Pages 1265-1275 , April 2006

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