Fertility and Sterility
Volume 85 , Pages 1248-1260 , April 2006

Evaluation of the embryonic preimplantation potential of human adult somatic cells via an embryo interspecies bioassay using bovine oocytes

  • Karl Illmensee, Ph.D.

      Affiliations

    • Reprogen, Limassol, Cyprus
    • Andrology Institute of America, Lexington, Kentucky, USA
  • ,
  • Mike Levanduski, Ph.D.

      Affiliations

    • Embryoserv Corporation, New York, New York, USA
  • ,
  • Panayiotis M. Zavos, Ed.S., Ph.D.

      Affiliations

    • Reprogen, Limassol, Cyprus
    • Andrology Institute of America, Lexington, Kentucky, USA
    • Corresponding Author InformationReprint requests: Panayiotis M. Zavos, Ph.D., Andrology Institute of America, P.O. Box 23777, Lexington, Kentucky 40523 (FAX: 859-278-6806).

Received 11 July 2005 ,Revised 28 October 2005 ,Accepted 28 October 2005.

References 

  1. Illmensee K , Hoppe PC . Nuclear transplantation in Mus musculus (developmental potential of nuclei from preimplantation embryos) . Cell . 1981;23:9–18
  2. Willadsen SM . Nuclear transplantation in sheep embryos . Nature . 1986;320:63–65
  3. Prather RS , Sims MM , First NL . Nuclear transplantation in early pig embryos . Biol Reprod . 1989;41:414–418
  4. Zhang Y , Wang J , Qian J , Hao Z . Nuclear transplantation in goat embryos . Sci Agric Sin . 1991;24:1–6
  5. Sims M , First NL . Production of calves by transfer of nuclei from cultured inner cell mass cells . Proc Natl Acad Sci U S A . 1994;91:6143–6247
  6. Meng L , Ely JJ , Stouffer RL , Wolf DP . Rhesus monkeys produced by nuclear transfer . Biol Reprod . 1997;57:454–459
  7. Wilmut I , Schnieke AE , McWhir J , Kind AJ , Campbell KHS . Viable offspring derived from fetal and adult mammalian cells . Nature . 1997;385:810–813
  8. Kato Y , Tani T , Sotomaru Y , Kurokawa K , Kato J , Doguchi H , et al.   Eight calves cloned from somatic cells of a single adult . Science . 1998;282:2095–2098
  9. Wells DN , Misica PM , Tervit HR . Production of cloned calves following nuclear transfer with cultured adult mural granulosa cells . Biol Reprod . 1999;60:996–1005
  10. Dominko T , Mitalipova M , Haley B , Beyhan Z , Memili E , McKusick B , et al.   Bovine oocyte cytoplasm supports development of embryos produced by nuclear transfer of somatic cell nuclei from various mammalian species . Biol Reprod . 1999;60:1496–1502
  11. Kubota C , Yamakuchi H , Todoroki J , Mizoshita K , Tabara N , Barber M , et al.   Six cloned calves produced from adult fibroblast cells after long-term culture . PNAS . 2000;97:990–995
  12. Kato Y , Tani T , Tsunoda Y . Cloning of calves from various somatic cell types of male and female adult, newborn and fetal cows . J Reprod Fertil . 2000;120:231–237
  13. Simerly C , Dominko T , Navara C , Payne C , Capuano S , Gosman G , et al.   Molecular correlates of primate nuclear transfer failures . Science . 2003;300:297
  14. Zhang Y , Li Y . Nuclear-cytoplasmic interaction and development of goat embryos reconstructed by nuclear transplantation (production of goats by serially cloning embryos) . Biol Reprod . 1998;58:266–269
  15. Zakhartchenko V , Durcova-Hills G , Stojkovic M , Schernthaner W , Prelle K , Steinborn R , et al.   Effects of serum starvation and recloning on the efficiency of nuclear transfer using bovine fetal fibroblasts . J Reprod Fertil . 1999;115:325–331
  16. Zavos PM , Illmensee K . Development of bioassays using the bovine model to measure the efficiency of SCNT in humans . Fertil Steril . 2003;80(Suppl 3):19–20
  17. Fulka J , First NL , Moor RM . Nuclear transplantation in mammals (remodelling of transplanted nuclei under the influence of maturation promoting factor) . Bioessays . 1996;18:835–840
  18. Wade PA , Kikyo N . Chromatin remodeling in nuclear cloning . Eur J Biochem . 2002;269:2284–2287
  19. Tian XC , Xu J , Yang X . Normal telomere length found in cloned cattle . Nature Genetics . 2000;26:272–273
  20. Betts D , Bordignon V , Hill J , Winger Q , Westhusin M , Smith L , et al.   Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle . PNAS . 2001;98:1077–1082
  21. Miyashita N , Shiga K , Yonai M . Remarkable differences in telomere length among cloned cattle derived from different cell types . Biol Reprod . 2002;66:1649–1655
  22. Clark AJ , Ferrier P , Aslam S , Burl S , Denning C , Wylie D , et al.   Proliferative lifespan is conserved after nuclear transfer . Nature Cell Biol . 2003;5:535–538
  23. Liu I , Dai Y , Moore RM . Nuclear transfer in sheep embryos (the effect of cell-cycle coordination between nucleus and cytoplasm and the use of in vitro matured oocytes) . Mol Reprod Dev . 1997;47:255–264
  24. Wells DN , Laible G , Tucker FC , Miller AL , Oliver JE , Xiang T , et al.   Coordination between donor cell type and cell cycle stage improves nuclear cloning efficiency in cattle . Theriogenology . 2003;59:45–59
  25. Dean W , Santos F , Stojkovic M , Zakhartchenko V , Walter J , Wolf E , et al.   Conservation of methylation reprogramming in mammalian development (aberrant reprogramming in cloned embryos) . PNAS . 2001;98:13734–13738
  26. Bourc’his D , Le Bourhis D , Patin D , Niveleau A , Comizzoli P , Renard JP , et al.   Delayed and incomplete reprogramming of chromosome methylation patterns in bovine cloned embryos . Curr Biol . 2001;11:1542–1546
  27. Shi W , Zakhartchenko V , Wolf E . Epigenetic reprogramming in mammalian nuclear transfer . Differentiation . 2003;71:91–113
  28. Zakartchenko V , Stojkovic M , Brem G , Wolf E . Karyoplast-cytoplast volume ratio in bovine nuclear transfer embryos (effect on developmental potential) . Mol Reprod Dev . 1997;48:332–338
  29. Du F , Sung L-Y , Tian C , Yang X . Differential cytoplast requirement for embryonic and somatic cell nuclear transfer in cattle . Mol Reprod Dev . 2002;63:183–191
  30. Tani T , Kato Y , Tsunoda Y . Direct exposure of chromosomes to nonactivated ovum cytoplasm is effective for bovine somatic cell nucleus reprogramming . Biol Reprod . 2001;64:324–330
  31. Lanza RP , Cibelli JB , West MD . Prospects for the use of nuclear transfer in human transplantation . Nat Biotechnol . 1999;17:1171–1174
  32. Chen Y , He ZX , Liu A , Wang K , Mao WW , Chu JX , et al.   Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes . Cell Res Online . 2003;13:251–264
  33. Chang KH , Lim JM , Kang SK , Lee BC , Moon SY , Hwang WS . Blastocyst formation, karyotype, and mitochondrial DNA of interspecies embryos derived from nuclear transfer of human cord fibroblasts into enucleated bovine oocytes . Fertil Steril . 2003;80:1380–1387
  34. Peura TT , Hartwich KM , Hamilton HM , Walker SK . No differences in sheep somatic cell nuclear transfer outcomes using serum-starved or actively growing donor granulosa cells . Reprod Fertil Dev . 2003;15:157–165
  35. Motlik J , Alberio R , Zakhartchenko V , Stojkovic M , Kubelka M , Wolf E . The effect of activation of mammalian oocytes on remodeling of donor nuclei after nuclear transfer . Cloning Stem Cells . 2002;4:245–252
  36. Lagutina I , Lazzari G , Duchi R , Galli C . Development potential of bovine androgenetic and parthenogenetic embryos (a comparative study) . Biol Reprod . 2004;70:400–405
  37. Thomson JA , Itskovitz-Eldor J , Shapiro SS , Waknitz MA , Swiergiel JJ , Marshall VS , et al.   Embryonic stem cell lines derived from human blastocysts . Science . 1998;282:1145–1147
  38. O’Shea KS . Directed differentiation of embryonic stem cells (genetic and epigenetic methods) . Wound Rep Regen . 2001;9:443–459
  39. Yang CX , Han ZM , Wen DC , Sun QY , Zhang KY , Zhang LS , et al.   In-vitro development and mitochondrial fate of macaca-rabbit cloned embryos . Mol Reprod Dev . 2003;65:394–401
  40. Steinborn R , Schinogl P , Zakhartchenko V , Achmann R , Schernthaner W , Stojkovic M , et al.   Mitochondrial DNA heteroplasmy in cloned cattle produced by fetal and adult cell cloning . Nat Genet . 2000;25:255–257
  41. Takeda K , Akagi S , Kaneyama K , Kojima T , Takahashi S , Imai H , et al.   Proliferation of donor mitochondrial DNA in nuclear transfer calves (Bos taurus) derived from cumulus cells . Mol Reprod Develop . 2003;64:429–437
  42. Hiendleder S , Wolf E . The mitochondrial genome in embryo technologies . Reprod Domest Anim . 2003;38:290–304
  43. Illmensee K . Cloning in reproductive medicine . J Assist Reprod Genetics . 2001;18:451–467
  44. Illmensee K . Therapeutic cloning in reproductive medicine . 2005;Vol. 1:832–836 Proceedings of the 12th World Congress on Human Reproduction, Venice, Italy

PII: S0015-0282(05)04203-2

doi: 10.1016/j.fertnstert.2005.10.026

Fertility and Sterility
Volume 85 , Pages 1248-1260 , April 2006