Fertility and Sterility
Volume 85, Issue 5 , Pages 1398-1403, May 2006

Urinary follicle-stimulating hormone (FSH) is more effective than recombinant FSH in older women in a controlled randomized study

  • Mohamed A. Mohamed, M.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Perinatology, “La Sapienza” University, Rome, Italy
    • ,
  • Marco Sbracia, M.D.

      Affiliations

    • Center for Endocrinology and Reproductive Medicine, Rome, Italy
    • Corresponding Author InformationReprint requests: Marco Sbracia, M.D., Center for Endocrinology and Reproductive Medicine, Via Carlo Porta 10, 00153, Rome, Italy (FAX: 9-06-5880096)
    • ,
  • Arianna Pacchiarotti, M.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Perinatology, “La Sapienza” University, Rome, Italy
    • ,
  • Giulietta Micara, B.S.

      Affiliations

    • Department of Obstetrics, Gynecology and Perinatology, “La Sapienza” University, Rome, Italy
    • ,
  • Antonella Linari, B.S.

      Affiliations

    • Department of Obstetrics, Gynecology and Perinatology, “La Sapienza” University, Rome, Italy
    • ,
  • Daniela Tranquilli, B.S.

      Affiliations

    • Department of Obstetrics, Gynecology and Perinatology, “La Sapienza” University, Rome, Italy
    • ,
  • Salomé M.B. Espinola, B.S.

      Affiliations

    • Department of Obstetrics, Gynecology and Perinatology, “La Sapienza” University, Rome, Italy
    • ,
  • Cesare Aragona, M.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Perinatology, “La Sapienza” University, Rome, Italy

Received 27 June 2005; received in revised form 25 October 2005; accepted 25 October 2005. published online 04 April 2006.

Objective

The following study was conducted to determine which FSH, recombinant or urinary, works better in older women.

Design

We conducted a controlled randomized study in a single university IVF center.

Setting

University IVF center.

Patient(s)

Women (N = 257) over 39 years old undergoing IVF.

Intervention(s)

The patients were randomized into two study groups at their first IVF cycle: 121 patients were treated with recombinant FSH, and 120 patients were treated with urinary FSH. Both groups were suppressed with a long GnRH analog protocol.

Main Outcome Measure(s)

Days of stimulation, E2 at the day of hCG, total amount of FSH administered, number of oocytes collected, amount of FSH per oocyte, and number of embryos obtained.

Result(s)

Patients treated with urinary FSH required a significantly lower total amount of FSH, and a lower amount of FSH per oocyte than women treated with recombinant FSH. The other measures evaluated did not show any statistically significant differences.

Conclusion(s)

Our study showed that urinary FSH performed better in older women than recombinant FSH when associated with the long protocol.

Key Words:  Urinary FSH , recombinant FSH , IVF outcome , controlled ovarian hyperstimulation

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 The work was performed at: Department of Obstetrics, Gynecology and Perinatology, Policlinico Umberto I Hospital, “La Sapienza” University, Rome, Italy.

PII: S0015-0282(06)00093-8

doi:10.1016/j.fertnstert.2005.10.049

Fertility and Sterility
Volume 85, Issue 5 , Pages 1398-1403, May 2006

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