Fertility and Sterility
Volume 85, Issue 5 , Pages 1364-1367, May 2006

The play of chance

  • John Collins, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    • Department of and Obstetrics and Gynecology, Dalhousie University, Halifax, Nova Scotia, Canada
    • Corresponding Author InformationReprint requests: John Collins, M.D., 400 Mader’s Cove Road, RR 1, Mahone Bay, Nova Scotia B0J 2E0, Canada (FAX: 902-624-0115).

Received 26 October 2005; received in revised form 26 October 2005; accepted 26 October 2005. published online 05 April 2006.

Most randomized controlled trials are small relative to the clinical question they address, and chance causes more variability in the results of small trials. Thus, when small studies herald new treatment interventions, clinicians might wish to wait until the body of evidence is weighty and consistent enough to be convincing.

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PII: S0015-0282(06)00211-1

doi:10.1016/j.fertnstert.2005.10.064

Fertility and Sterility
Volume 85, Issue 5 , Pages 1364-1367, May 2006

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