Next »
Fertility and Sterility
Volume 85, Issue 5
, Pages 1307-1318
, May 2006
Aromatase inhibitors: the next generation of therapeutics for endometriosis?
References
- . The epidemiology of pelvic endometriosis . Clin Obstet Gynecol . 1988;31:787–800
-
.
The epidemiology of endometriosis
.
Ann NY Acad Sci
. 2002;955:11–22
- . Endometriosis (associations with menorrhagia, infertility and oral contraceptives) . Int J Gynaecol Obstet . 1980;17:573–576
- . Epidemiology of endometriosis . Obstet Gynecol Clin North Am . 1997;24:235–258
- . Delay in the diagnosis of endometriosis (a survey of women from the USA and the UK) . Hum Reprod . 1996;11:878–880
- . Aromatase (a key molecule in the pathophysiology of endometriosis and a therapeutic target) . Fertil Steril . 1999;72:961–969
- Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis . Endocr Rev . 1994;15:342–355
- Aromatase–a brief overview . Annu Rev Physiol . 2002;64:93–127
- . Aromatase inhibition and inactivation . Clin Cancer Res . 2001;7:4343s–4349s
- Estrogen production in endometriosis and use of aromatase inhibitors to treat endometriosis . Endocr Relat Cancer . 1999;6:293–301
- . Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue . Mol Endocrinol . 2002;16:2243–2254
- Aromatase—a brief overview . Annu Rev Physiol . 2002;64:93–127
-
Aromatase expression in health and disease
. 1997;52:185–214
-
.
Tissue-specific regulation of aromatase cytochrome P450 expression
.
In:
Schenkmon JB
, Greim H
editor.
Handbook of experimental pharmacology cytochrome P450
. Berlin: Springer-Verlag; 1993;p. 611–625
-
Regulation of expression of the gene encoding aromatase cytochrome P450
.
In:
Nunez J
, Dumont JE
editor.
Hormones and cell regulation
. London, UK: Libby; 1992;p. 49–55
- Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells . J Clin Endocrinol Metab . 1997;82:600–606
- . Stimulation of aromatase P450 promoter (II) activity in endometriosis and its inhibition in endometrium are regulated by competitive binding of SF-1 and COUP-TF to the same cis-acting element . Mol Endocrinol . 1999;13:239–253
- . Aromatase expression in endometriosis . J Clin Endocrinol Metab . 1996;81:174–179
- . Distinct regulation of cyclooxygenase-2 by interleukin-1{beta} in normal and endometriotic stromal cells . J Clin Endocrinol Metab . 2005;90(1):286–295
- . Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis . Hum Reprod . 2001;16:561–566
- Role of aromatase in endometrial disease . J Steroid Biochem Mol Biol . 2001;79:19–25
- . Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells . J Clin Endocrinol Metab . 2001;86:5765–5773
- . Aromatase inhibitors in the treatment and prevention of breast cancer . J Clin Oncol . 2001;19:881–894
- . Advances in aromatase inhibition (clinical efficacy and tolerability in the treatment of breast cancer) . Clin Cancer Res . 2001;7:2620–2635
- . An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane . Cancer . 2002;95:2006–2016
- Inhibition of breast cancer tissue aromatase activity and estrogen concentrations by the third-generation aromatase inhibitor vorozole . Cancer Res . 1997;57:2109–2111
- . Aminoglutethimide (review of pharmacology and clinical use) . Pharmacotherapy . 1981;1:95–120
- . Suppression of estrogens with aminoglutethimide and hydrocortisone (medical adrenalectomy) as treatment of advanced breast carcinoma (a review) . Breast Cancer Res Treat . 1981;1:183–202
- . Aminoglutethimide inhibits extraglandular estrogen production in postmenopausal women with breast carcinoma . J Clin Endocrinol Metab . 1978;47:1257–1265
- . Use of aminoglutethimide and hydrocortisone as a “medical adrenalectomy” for treatment of breast carcinoma . Prog Clin Cancer . 1982;8:245–265
-
.
Clinical use of aromatase inhibitors
(current data and future perspectives)
.
J Enzym Inhib
. 1990;4:79–99
- . Endocrine treatment of breast cancer in women . Endocr Rev . 1990;11:221–265
- . Recent progress in development of aromatase inhibitors . J Steroid Biochem Mol Biol . 1990;37:1029–1035
- . Endocrine treatment of advanced breast cancer . Acta Oncol . 1996;35(Suppl 5):68–72
- . Anastrozole–a new generation in aromatase inhibition (clinical pharmacology) . Oncology . 1997;54(Suppl 2):11–14
- . ARIMIDEX (a potent and selective aromatase inhibitor for the treatment of advanced breast cancer) . J Steroid Biochem Mol Biol . 1997;61:145–149
- . Aromatase inhibitors in metastatic breast cancer . Semin Oncol . 1996;23:28–32
- . Update on endocrine therapy for breast cancer . Clin Cancer Res . 1998;4:527–534
- Letrozole, a new oral aromatase inhibitor for advanced breast cancer (double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate) . J Clin Oncol . 1998;16:453–461
- Letrozole, a new oral aromatase inhibitor (randomised trial comparing 2.5 mg daily, 0.5 mg daily and aminoglutethimide in postmenopausal women with advanced breast cancer) . Ann Oncol . 1998;9:639–645
- The efficacy of CGS 20267 in suppressing estrogen biosynthesis in patients with advanced stage breast cancer . J Steroid Biochem Mol Biol . 1993;44:687–691
- . Arimidex (a potent and selective fourth-generation aromatase inhibitor) . Breast Cancer Res Treat . 1994;30:103–111
- . In vivo measurement of aromatase inhibition by letrozole (CGS 20267) in postmenopausal patients with breast cancer . Clin Cancer Res . 1995;1:1511–1515
- A randomised comparison of oestrogen suppression with anastrozole and formestane in postmenopausal patients with advanced breast cancer . Oncology . 1997;54(Suppl 2):19–22
- . Exemestane . Drugs . 1999;58:675–680
- . Anastrazole and oral oral contraceptives (a novel treatment for endometriosis) . Fertil Steril . 2005;84(2):300–304
- . The ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial (an update) . Clin Breast Cancer . 2004;5(Suppl 1):S6–S12
- . The effects of tamoxifen on the female genital tract . Cancer Treat Rev . 2004;30:291–301
- . Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate (a pilot study) . Fertil Steril . 2004;81:290–296
- . The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis (a prospective randomized trial) . Hum Reprod . 2004;19:160–167
- . A highly complex organization of the regulatory region of the human CYP19 (aromatase) gene revealed by the human genome project . J Clin Endocrinol Metab . 2001;86:4600–4602
- . Use of a specific aromatase inhibitor for determining whether there is a role for oestrogen in follicle/oocyte maturation, ovulation and preimplantation embryo development . J Reprod Fertil Suppl . 1996;50:69–81
- . Resistance of the ovary to blockade of aromatization with aminoglutethimide . J Clin Endocrinol Metab . 1980;51:473–477
- . Endocrine and therapeutic effects of aminoglutethimide in premenopausal patients with breast cancer . J Clin Endocrinol Metab . 1982;55:718–722
- . Aminoglutethimide in the treatment of premenopausal patients with metastatic breast cancer . Eur J Cancer Clin Oncol . 1986;22:1371–1374
- Treatment of advanced breast cancer in postmenopausal women with 4-hydroxyandrostenedione . Cancer Chemother Pharmacol . 1990;26:75–78
- R 76713, a new specific non-steroidal aromatase inhibitor . J Steroid Biochem . 1989;32:781–788
- . The clinical and endocrine effects of 4-hydroxyandrostenedione alone and in combination with goserelin in premenopausal women with advanced breast cancer . Br J Cancer . 1990;62:679–683
- . Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate . Fertil Steril . 2001;75:305–309
- . Hormonal profile and endometrial morphology in letrozole-controlled ovarian hyperstimulation in ovulatory infertile patients . Fertil Steril . 2005;83:110–115
- . A randomized double-blind comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on ovulatory function in normal women . Fertil Steril . 2002;78:280–285
- . Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders . Fertil Steril . 2002;77:776–780
- . Aromatase inhibition reduces the dose of gonadotropin required for controlled ovarian hyperstimulation . J Soc Gynecol Investig . 2004;11:406–415
- A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response (a preliminary report) . Hum Reprod . 2004;19:2031–2035
- . Clinical and endocrine data for goserelin plus anastrozole as second-line endocrine therapy for premenopausal advanced breast cancer . Br J Cancer . 2004;90:590–594
- . A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis . Fertil Steril . 1993;60:75–79
- . Gonadotropin-releasing hormone analogues for the treatment of endometriosis (long-term follow-up) . Fertil Steril . 1993;59:511–515
- . Endometriosis and pelvic pain. Relation to disease stage and localization . Fertil Steril . 1996;65:299–304
- . Changing concepts of medical treatment of endometriosis . Acta Obstet Gynecol Scand . 1993;72:324–336
- . Pelvic denervation for chronic pain associated with endometriosis (fact or fancy?) . Am J Obstet Gynecol . 1991;165:745–749
-
.
Surgical interruption of pelvic nerve pathways for primary and secondary dysmenorrhoea
.
Cochrane Database Syst Rev
. 2000;(2):CD001896
- . Consensus statement for the management of chronic pelvic pain and endometriosis (proceedings of an expert-panel consensus process) . Fertil Steril . 2002;78:961–972
-
.
The treatment of endometriosis
(a review of the evidence)
.
Ann NY Acad Sci
. 2002;955:360–372
- . Long-term use of gonadotropin-releasing hormone analogs and hormone replacement therapy in the management of endometriosis (a randomized trial with a 6-year follow-up) . Fertil Steril . 2000;74:964–968
- . Endometriosis and pain . Clin Obstet Gynecol . 1999;42:664–686
-
.
Surgical management of endometriosis
.
Baillieres Best Pract Res Clin Obstet Gynaecol
. 2000;14:501–523
- . Successful treatment of severe endometriosis in two premenopausal women with an aromatase inhibitor . Fertil Steril . 2004;81:1395–1398
- . Treatment of severe postmenopausal endometriosis with an aromatase inhibitor . Fertil Steril . 1998;69:709–713
-
.
Treatment of severe recurrent endometriosis with an aromatase inhibitor in a young ovariectomised woman
.
Br J Obstet Gynaecol
. 2004;111:182–184
- . Dosage aspects of danazol therapy in endometriosis (short-term and long-term effectiveness) . Am J Obstet Gynecol . 1981;139:645–654
- Aromatase in endometriosis and uterine leiomyomata . J Steroid Biochem Mol Biol . 2005;95(1–5):57–62
Supported by National Institutes of Health (Bethesda, MD) grant HD 36891 and a grant from Friends of Prentice, Chicago, Illinois.
PII: S0015-0282(06)00228-7
doi: 10.1016/j.fertnstert.2005.09.064
© 2006 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Next »
Fertility and Sterility
Volume 85, Issue 5
, Pages 1307-1318
, May 2006

