Müllerian anomalies, hearing loss, and connexin 26 mutations

Rabinson, Jacob; Orvieto, Raoul; Shapira, Amnon; Brownstein, Zippora; Meltzer, Simion; Tur-Kaspa, Ilan

doi:10.1016/j.fertnstert.2005.11.050

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Volume 85, Issue 6 , Pages 1824-1825, June 2006

Müllerian anomalies, hearing loss, and connexin 26 mutations

Jacob Rabinson, M.D.
- Infertility and IVF Unit, Departments of Obstetrics and Gynecology, Barzilai Medical Center, Ben-Gurion University, Ashkelon, Israel
Raoul Orvieto, M.D., M.Sc.
- Infertility and IVF Unit, Departments of Obstetrics and Gynecology, Barzilai Medical Center, Ben-Gurion University, Ashkelon, Israel
- Reprint requests: Ilan Tur-Kaspa, M.D., Director, Institute for Human Reproduction and the Clinical IVF-PGD Program at the Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, Illinois 60657. (FAX: 1-773-935-3691)
Amnon Shapira, M.D.
- Department of Otolaryngology, Barzilai Medical Center, Ben-Gurion University, Ashkelon, Israel
Zippora Brownstein, M.Sc.
- Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Simion Meltzer, M.D.
- Infertility and IVF Unit, Departments of Obstetrics and Gynecology, Barzilai Medical Center, Ben-Gurion University, Ashkelon, Israel
Ilan Tur-Kaspa, M.D.
- Infertility and IVF Unit, Departments of Obstetrics and Gynecology, Barzilai Medical Center, Ben-Gurion University, Ashkelon, Israel
- Institute for Human Reproduction and Reproductive Genetics Institute, Chicago, Illinois

Received 14 August 2005; received in revised form 25 November 2005; accepted 25 November 2005. published online 01 May 2006.

In a study of the possible inter-relationship among müllerian anomalies, hearing loss, and connexin 26 mutations, we evaluated all women in whom müllerian anomalies were diagnosed on hysterosalpingography during a 6-year period (n = 24/519). Audiometric testing revealed five (22.7%) with unrecognized sensorineural hearing loss; however, on genetic evaluation, none harbored a connexin 26 mutation.