Fertility and Sterility
Volume 86, Issue 3 , Pages 658-663 , September 2006

Pregnancy outcome after first-trimester exposure to metformin: a meta-analysis

Presented at the Canadian Society for Clinical Pharmacology 2005 Annual Meeting in Vancouver, British Columbia, Canada, April 16, 2005.

  • Cameron Gilbert, M.Sc.

      Affiliations

    • Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    • ,
  • Maria Valois, M.D., FRCPC, Ph.D.

      Affiliations

    • The Scarborough Hospital, Toronto, Ontario, Canada
    • ,
  • Gideon Koren, M.D.

      Affiliations

    • Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    • Corresponding Author InformationReprint requests: Gideon Koren, M.D., Division of Clinical Pharmacology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada (FAX: 416-813-7562).

Received 12 July 2005 ,Revised 13 February 2006 ,Accepted 13 February 2006.

References 

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  2. Hellmuth E , Damm P , Molsted-Pedersen L . Congenital malformations in offspring of diabetic women treated with oral hypoglycaemic agents during embryogenesis . Diabet Med . 1994;11(5):471–474
  3. Hellmuth E , Damm P , Molsted-Pedersen L . Oral hypoglycaemic agents in 118 diabetic pregnancies . Diabet Med . 2000;17(7):507–511
  4. Piacquadio K , Hollingsworth DR , Murphy H . Effects of in-utero exposure to oral hypoglycaemic drugs . Lancet . 1991;338(8771):866–869
  5. Towner D , Kjos SL , Leung B , Montoro MM , Xiang A , Mestman JH , et al.   Congenital malformations in pregnancies complicated by NIDDM . Diabetes Care . 1995;18(11):1446–1451
  6. Denno KM , Sadler TW . Effects of the biguanide class of oral hypoglycemic agents on mouse embryogenesis . Teratology . 1994;49:260–266
  7. Ben Haroush A , Yogev Y , Fisch B . Insulin resistance and metformin in polycystic ovary syndrome . Eur J Obstet Gynecol Reprod Biol . 2004;115:125–133
  8. McCarthy EA , Walker SP , McLachlan K , Boyle J , Permezel M . Metformin in obstetric and gynecologic practice: a review . Obstet Gynecol Surv . 2004;59:118–127
  9. Gargaun S , Ryan E , Greenblatt E , Fettes I , Shapiro H , Padjen A , et al.   Pregnancy outcome in women with polycystic o to metformin . Can J Clin Pharmacol . 2003;10:149
  10. Jakubowicz DJ , Iuorno MJ , Jakubowicz S , Roberts KA , Nestler JE . Effects of metformin on early pregnancy loss in the polycystic ovary syndrome . J Clin Endocrinol Metab . 2002;87:524–529
  11. Glueck CJ , Wang P , Kobayashi S , Phillips H , Sieve-Smith L . Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome . Fertil Steril . 2002;77:520–525
  12. Begg CB , Mazumdar M . Operating characteristics of a rank correlation test for publication bias . Biometrics . 1994;50:1088–1101
  13. Coetzee EJ , Jackson WP . Oral hypoglycaemics in the first trimester and fetal outcome . S Afr Med J . 1984;65:635–637
  14. Piacquadio K , Hollingsworth DR , Murphy H . Effects of in utero exposure to oral hypoglycaemic drugs . Lancet . 1991;338:866–869
  15. Hellmuth E , Damm P , Molsted-Pedersen L . Oral hypoglycaemic agents in 118 diabetic pregnancies . Diabet Med . 2000;17:507–511
  16. Vandermolen DT , Ratts VS , Evans WS , Stovall DW , Kauma SW , Nestler JE . Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone . Fertil Steril . 2001;75:310–315
  17. Sahin Y , Yirmibes U , Kelestimur F , Aygen E . The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome . Eur J Obstet Gynecol Reprod Biol . 2004;113:214–220
  18. Duval S , Tweedie R . Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis . Biometrics . 2000;56:455–463
  19. Koren G . Maternal-fetal toxicology: a clinician’s guide . New York, NY: Marcel Dekker; 2001;

PII: S0015-0282(06)00964-2

doi: 10.1016/j.fertnstert.2006.02.098

Fertility and Sterility
Volume 86, Issue 3 , Pages 658-663 , September 2006

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