Fertility and Sterility
Volume 86, Issue 4, Supplement , Pages 1121-1128 , October 2006

Long-term suppression of reproductive function by a single dose of gonadotropin-releasing hormone antagonists in a sheep model

  • Antonio Gonzalez-Bulnes, Ph.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, Midlothian, United Kingdom
    • Departamento de Reproduccion Animal, Instituto Nacional de Investigaciones Agrarias, Madrid, Spain
    • Corresponding Author InformationReprint requests: Antonio Gonzalez-Bulnes, Ph.D., Departamento de Reproduccion Animal, Instituto Nacional de Investigaciones Agrarias, Avenida Puerta de Hierro s/n. 28040-Madrid, Spain (FAX: 00-34-91-347-40-14).
    • ,
  • Carlos J.H. Souza, Ph.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, Midlothian, United Kingdom
    • Embrapa Pecuaria Sul, Bage, Brazil
    • ,
  • Rex J. Scaramuzzi, Ph.D.

      Affiliations

    • Division of Veterinary Basic Sciences, Royal Veterinary College, London, United Kingdom
    • ,
  • Bruce K. Campbell, Ph.D.

      Affiliations

    • School of Human Development, Queen Medical Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom
    • ,
  • David T. Baird, Ph.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, Midlothian, United Kingdom

Received 14 November 2005 ,Revised 15 February 2006 ,Accepted 15 February 2006.

References 

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  2. Reissmann T , Felberbaum R , Diedrich K , Engel J , Comaru-Schally AM , Schally AV . Development and applications of luteinizing hormone-releasing hormone antagonists in the treatment of infertility: an overview . Hum Reprod . 1993;10:1974–1981
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  8. Oussaid B , Mariana JC , Poulin N , Fontaine J , Lonergan P , Beckers JF , et al.   Reduction of the developmental competence of sheep oocytes by inhibition of LH pulses during the follicular phase with a GnRH antagonist . J Reprod Fertil . 1999;117:71–77
  9. Dufour JJ , Cognie Y , Mermillod P , Mariana JC , Romain RF . Effects of the Booroola Fec gene on ovarian follicular populations in superovulated Romanov ewes pretreated with a GnRH antagonist . J Reprod Fertil . 2000;118:85–94
  10. Campbell BK , Dobson H , Scaramuzzi RJ . Ovarian function in ewes made hypogonadal with GnRH antagonist and stimulated with FSH in the presence or absence of low amplitude LH pulses . J Endocrinol . 1998;156:213–222
  11. Cognie Y , Baril G , Poulin N , Mermillod P . Current status of embryo technologies in sheep and goats . Theriogenology . 2003;59:171–188
  12. Blache D , Chagas LM , Caraty A , Deghenghi R , Delaleu B , Blackberry MA , et al.   GnRH secretion into CSF in rams treated with a GnRH antagonist . J Neuroendocrinol . 1997;9:887–892
  13. Baird DT , Land RB , Scaramuzzi RJ , Wheeler AG . Functional assessment of the autotransplanted uterus and ovary in the ewe . Proc R Soc Lond B Biol Sci . 1976;192:463–474
  14. Campbell BK , Mann GE , McNeilly AS , Baird DT . The pattern of ovarian inhibin, estradiol, and androstenedione secretion during the estrous cycle of the ewe . Endocrinology . 1990;127:227–235
  15. McNeilly AS , Fraser HM . Effect of gonadotrophin-releasing hormone agonist-induced suppression of LH and FSH on follicle growth and corpus luteum function in the ewe . J Endocrinol . 1987;115:273–282
  16. Knight PG , Feist SA , Tanetta DS , Bleach ECL , Fowler PA , O’Brien M , et al.   Measurement of inhibin-A (α-β dimer) during the estrous cycle, after manipulation of ovarian activity and during pregnancy in ewes . J Reprod Fertil . 1998;113:159–166
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  19. Campbell BK , Dobson H , Baird DT , Scaramuzzi RJ . Studies on the role of LH in the maturation of the pre-ovulatory follicle in a sheep using a GnRH-antagonist . Anim Reprod Sci . 1997;48:219–234
  20. Campbell BK , McNeilly AS , Picton HM , Baird DT . The effect of a potent gonadotrophin-releasing hormone antagonist on ovarian secretion of oestradiol, inhibin and androstenedione and the concentration of LH and FSH during the follicular phase of the sheep oestrous cycle . Endocrinology . 1990;126:377–384
  21. Baird DT , Campbell BK , Mann GE , McNeilly AS . Inhibin and oestradiol in the control of FSH secretion in the sheep . J Reprod Fertil Suppl . 1991;43:125–138
  22. Webb R , Nicholas B , Gong JG , Campbell BK , Gutierrez CG , Garverick HA , et al.   Mechanisms regulating follicular development and selection of the dominant follicle . Reproduction . 2003;61:71–90
  23. Gonzalez-Bulnes A , Baird DT , Campbell BK , Cocero MJ , Garcia-Garcia RM , Inskeep EK , et al.   Multiple factors affecting the efficiency of multiple ovulation and embryo transfer in sheep and goats . Reprod Fertil Dev . 2004;16:421–435
  24. Picton HM , McNeilly AS . Effect of basal and pulsatile LH release on FSH-stimulated follicle growth in ewes chronically treated with gonadotrophin-releasing hormone agonist . Endocrinology . 1991;128:449–456
  25. Campbell BK , Souza C , Gong J , Webb R , Kendall N , Marsters P , et al.   Domestic ruminants as models for the elucidation of the mechanisms controlling ovarian follicle development in humans . Reprod Suppl . 2003;61:429–443

 Supported by a grant (G9827407) from the Medical Research Council (United Kingdom). Also supported by a fellowship under the Organisation for Economic Co-operation and Development in the United Kingdom and by the Programa “Ramon y Cajal” in Spain (both, A.G.B.).

PII: S0015-0282(06)01079-X

doi: 10.1016/j.fertnstert.2006.02.104

Fertility and Sterility
Volume 86, Issue 4, Supplement , Pages 1121-1128 , October 2006

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