Fertility and Sterility
Volume 86, Issue 4, Supplement , Pages 1129-1136 , October 2006

Role of cytosolic malate dehydrogenase in oocyte maturation and embryo development

Presented at the 60th annual meeting of the American Society for Reproductive Medicine, Philadelphia, Pennsylvania.

  • Se-Jin Yoon, Ph.D.

      Affiliations

    • CHA Research Institute, Fertility Center, CHA General Hospital, Seoul
    • Department of Biological Science, College of Natural Sciences, Chung-Ang University, Seoul
  • ,
  • Deog-Bon Koo, Ph.D.

      Affiliations

    • Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon
  • ,
  • Jung Sun Park, M.Sc.

      Affiliations

    • Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon
  • ,
  • Kyung-Hee Choi, Ph.D.

      Affiliations

    • Department of Biological Science, College of Natural Sciences, Chung-Ang University, Seoul
  • ,
  • Yong-Mahn Han, Ph.D.

      Affiliations

    • Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejon
  • ,
  • Kyung-Ah Lee, Ph.D.

      Affiliations

    • CHA Research Institute, Fertility Center, CHA General Hospital, Seoul
    • Graduate School of Life Science and Biotechnology, Pochon CHA University, Seoul, Korea
    • Corresponding Author InformationReprint requests: Kyung-Ah Lee, Ph.D., Graduate School of Life Science and Biotechnology, Pochon CHA University College of Medicine, 606-13, Yeoksam-1-dong, Gangnam-gu, Seoul, 135-081, Korea (FAX: 82-2-563-2028).

Received 7 October 2005 ,Revised 13 February 2006 ,Accepted 13 February 2006.

References 

  1. Gardner DK . Changes in requirements and utilization of nutrients during mammalian preimplantation embryo development and their significance in embryo culture . Theriogenology . 1998;49:83–102
  2. Pinyopummintr T , Bavister BD . In vitro-matured/in vitro-fertilized bovine oocytes can develop into morulae/blastocysts in chemically defined, protein-free culture media . Biol Reprod . 1991;45:736–742
  3. Krisher RL , Bavister BD . Responses of oocytes and embryos to the culture environment . Theriogenology . 1998;49:103–114
  4. Sutton ML , Gilchrist RB , Thompson JG . Effects of in-vivo and in-vitro environments on the metabolism of the cumulus-oocyte complex and its influence on oocyte developmental capacity . Hum Reprod Update . 2003;9:35–48
  5. Zhang L , Jiang S , Wozniak PJ , Yang X , Godke RA . Cumulus cell function during bovine oocyte maturation, fertilization, and embryo development in vitro . Mol Reprod Dev . 1995;40:338–344
  6. Cetica PD , Dalvit GC , Beconi MT . Study of evaluation criteria used for in vitro bovine oocyte selection and maturation . Biocell . 1999;23:125–133
  7. Fatehi AN , Zeinstra EC , Kooij RV , Colenbrander B , Bevers MM . Effect of cumulus cell removal of in vitro matured bovine oocytes prior to in vitro fertilization on subsequent cleavage rate . Theriogenology . 2002;57:1347–1355
  8. Zuelke KA , Brackett BG . Increased glutamine metabolism in bovine cumulus cell-enclosed and denuded oocytes after in vitro maturation with luteinizing hormone . Biol Reprod . 1993;48:815–820
  9. Cetica PD , Pintos LN , Dalvit GC , Beconi MT . Effect of lactate dehydrogenase activity and isoenzyme localization in bovine oocytes and utilization of oxidative substrates on in vitro maturation . Theriogenology . 1999;51:541–550
  10. Cetica P , Pintos L , Dalvit G , Beconi M . Involvement of enzymes of amino acid metabolism and tricarboxylic acid cycle in bovine oocyte maturation in vitro . Reproduction . 2003;126:753–763
  11. Sutton ML , Cetica PD , Beconi MT , Kind KL , Gilchrist RB , Thompson JG . Influence of oocyte-secreted factors and culture duration on the metabolic activity of bovine cumulus cell complexes . Reproduction . 2003;126:27–34
  12. Buccione R , Schroeder AC , Eppig JJ . Interactions between somatic cells and germ cells throughout mammalian oogenesis . Biol Reprod . 1990;43:543–547
  13. Biggers JD , Whittingham DG , Donahue RP . The pattern of energy metabolism in the mouse oocyte and zygote . Proc Natl Acad Sci USA . 1967;58:560–567
  14. Webb LE , Hill EJ , Banaszak LJ . Conformation of nicotinamide adenine dinucleotide bound to cytoplasmic malate dehydrogenase . Biochemistry . 1973;12:5101–5109
  15. Grant PM , Roderick SL , Grant GA , Banaszak LJ , Strauss AW . Comparison of the precursor and mature forms of rat heart mitochondrial malate dehydrogenase . Biochemistry . 1987;26:128–134
  16. Lane M , Gardner DK . Mitochondrial malate-aspartate shuttle regulates mouse embryo nutrient consumption . J Biol Chem . 2005;280:18361–18367
  17. Yoon SJ , Chung HM , Cha KY , Kim NH , Lee KA . Identification of differential gene expression in germinal vesicle vs. metaphase II mouse oocytes using annealing control primers . Fertil Steril . 2005;83(Suppl 1):1293–1296
  18. Zeng F , Baldwin DA , Schultz RM . Transcript profiling during preimplantation mouse development . Dev Biol . 2004;272:483–496
  19. Fire A , Xu S , Montgomery MK , Kostas SA , Driver SE , Mello CC . Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans . Nature . 1998;391:806–811
  20. Wianny F , Zernicka-Goetz M . Specific interference with gene function by double-stranded RNA in early mouse development . Nat Cell Biol . 1999;2:70–75
  21. Svoboda P , Stein P , Hayashi H , Schultz RM . Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference . Development . 2000;127:4147–4156
  22. Park CE , Shin MR , Jeon EH , Lee SH , Cha KY , Kim K , et al.   Oocyte-selective expression of MT transposon-like element, clone MTi7 and its role in oocyte maturation and embryo development . Mol Reprod Dev . 2004;69:365–374
  23. Rieger D , Loskutoff NM . Changes in the metabolism of glucose, pyruvate, glutamine and glycine during maturation of cattle oocytes in vitro . J Reprod Fertil . 1994;100:257–262
  24. Whittingham DG , Biggers JD . Fallopian tube and early cleavage in the mouse . Nature . 1967;213:942–943
  25. Brinster RL . Studies on the development of mouse embryos in vitro II (The effect of energy source) . J Exp Zool . 1965;158:59–68
  26. Brinster RL , Thomson JL . Development of eight-cell mouse embryos in vitro . Exp Cell Res . 1966;42:308–315
  27. Kovacevic Z . Possibility for the transfer of reducing equivalents from the cytosol to the mitochondrial compartment in Ehrlich ascites tumor cells by the malate-aspartate shuttle . Eur J Biochem . 1972;25:372–378
  28. Greenhouse WV , Lehninger AL . Occurrence of the malate-aspartate shuttle in various tumor types . Cancer Res . 1976;36:1392–1396
  29. Cooper AJ , Lai JC . Cerebral ammonia metabolism in normal and hyperammonemic rats . Neurochem Pathol . 1987;6:67–95
  30. Faff-Michalak L , Albrecht J . Aspartate aminotransferase, malate dehydrogenase, and pyruvate carboxylase activities in rat cerebral synaptic and nonsynaptic mitochondria: effects of in vitro treatment with ammonia, hyperammonemia and hepatic encephalopathy . Metab Brain Dis . 1991;6:187–197

 Supported by a grant from KRIBB Research Initiative Program, Daejeon, Korea.

PII: S0015-0282(06)01080-6

doi: 10.1016/j.fertnstert.2006.02.105

Fertility and Sterility
Volume 86, Issue 4, Supplement , Pages 1129-1136 , October 2006