Fertility and Sterility
Volume 86, Issue 6 , Pages 1634-1641 , December 2006

Factors influencing adverse perinatal outcomes in pregnancies achieved through use of in vitro fertilization

Presented at the 61st Annual Meeting of the American Society for Reproductive Medicine, Montreal, Canada.

  • Karine Chung, M.D., M.S.C.E.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania
    • Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania
    • Corresponding Author InformationReprint requests: Karine Chung, M.D., M.S.C.E., LAC-USC Women’s and Children’s Hospital, 1240 N. Mission Road, Room 8K9, Los Angeles, California 90033 (FAX: 323-226-2850).
    • ,
  • Christos Coutifaris, M.D., Ph.D.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Raffi Chalian, M.D.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Kathleen Lin, M.D.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Sarah J. Ratcliffe, Ph.D.

      Affiliations

    • Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Arthur J. Castelbaum, M.D.

      Affiliations

    • Northern Fertility and Reproductive Associates, Meadowbrook, Pennsylvania
    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Temple University, Philadelphia, Pennsylvania
    • ,
  • Martin F. Freedman, M.D.

      Affiliations

    • Northern Fertility and Reproductive Associates, Meadowbrook, Pennsylvania
    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Temple University, Philadelphia, Pennsylvania
    • ,
  • Kurt T. Barnhart, M.D., M.S.C.E.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania
    • Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania

Received 28 September 2005 ,Revised 19 April 2006 ,Accepted 19 April 2006.

References 

  1. Centers for Disease Control and PreventionAmerican Society for Reproductive MedicineSociety for Assisted Reproductive Technology, RESOLVE. 2002 assisted reproductive technology success rates: national summary and fertility clinic reports. Atlanta: Centers for Disease Control and Prevention; 2005;
  2. Schieve LA, Meikle SF, Ferre C, Peterson HB, Jeng G, Wilcox LS. Low and very low birth weight in infants conceived with use of assisted reproductive technology. N Engl J Med. 2002;346:731–737
  3. Kovalevsky G, Rinaudo P, Coutifaris C. Do assisted reproductive technologies cause adverse fetal outcomes?. Fertil Steril. 2003;79:1270–1272
  4. Schieve LA, Ferre C, Peterson HB, Macaluso M, Reynolds MA, Wright VC. Perinatal outcome among singleton infants conceived through assisted reproductive technology in the United States. Obstet Gynecol. 2004;103:1144–1153
  5. Jackson RA, Gibson KA, Wu YW, Croughan MS. Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol. 2004;103:551–563
  6. McGovern PG, Llorens AJ, Skurnick JH, Weiss G, Goldsmith LT. Increased risk of preterm birth in singleton pregnancies resulting from in vitro fertilization-embryo transfer or gamete intrafallopian transfer: a meta-analysis. Fertil Steril. 2004;82:1514–1520
  7. Helmerhorst FM, Perquin DA, Donker D, Keirse MJ. Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. Br Med J [Clin Res]. 2004;328:261
  8. Copper RL, Goldenberg RL, Creasy RK, DuBard MB, Davis RO, Entmann SS, et al. A multicenter study of pre-term birth weight and gestational age specific neonatal mortality. Am J Obstet Gynecol. 1993;168:78–84
  9. Godfrey K, Robinson S, Barker DJP, Osmond C, Cox V. Maternal nutrition in early and late pregnancy in relation to placental and fetal growth. Br Med J [Clin Res]. 1996;312:410–414
  10. Kwong WY, Wild AE, Roberts P, Willis AC, Fleming TP. Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension. Development. 2000;127:4195–4202
  11. Hansen M, Kurinczuk J, Bower C, Webb S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med. 2002;346:725–730
  12. Johnson MR, Irvine R, Hils F, Bolton VN, Abbas AA, Brooks AA, et al. Superovulation, IGFBP-1, and birth weight. Eur J Obstet Gynecol Reprod Biol. 1995;59:193–195
  13. Weiss G, Goldsmith LT, Sachdev R, Von Hagen S, Lederer K. Elevated first-trimester serum relaxin concentrations in pregnant women following ovarian stimulation predict prematurity risk and preterm delivery. Obstet Gynecol. 1993;82:821–828
  14. Isaksson R, Gissler M, Tiitinen A. Obstetric outcome among women with unexplained infertility after IVF: a matched case-control study. Hum Reprod. 2002;17:1755–1761
  15. Veeck LL. In: Atlas of human oocyte and early conceptus. Vol. 2:Baltimore: Williams and Wilkins; 1991;p. 427–444
  16. Hsu M, Mayer J, Aronshon M, Lanzendorf S, Muasher S, Kolm P, et al. Embryo implantation in in vitro fertilization and intracytoplasmic sperm injection: impact of cleavage status, morphology grade, and number of embryos transferred. Fertil Steril. 1999;72:679–685
  17. Desai NN, Goldstein J, Rowland DY, Goldfarb JM. Morphological evaluation of human embryos and derivation of an embryo quality scoring system specific for day 3 embryos: a preliminary study. Hum Reprod. 2000;15:2190–2196
  18. Strandell A, Lindhard A, Waldenstrom U, Thorburn J, Janson PO, Hamberger L. Hydrosalpinx and IVF outcome: a prospective, randomized multicentre trial in Scandinavia on salpingectomy prior to IVF. Hum Reprod. 1999;14:2762–2769
  19. Pouly JL, Chapron C, Manhes H, Canis M, Wattiez A, Bruhat MA. Multifactorial analysis of fertility after conservative laparoscopic treatment if ectopic pregnancy in a series of 223 patients. Fertil Steril. 1991;56:452–460
  20. Mol BW, Collins JA, Burrows EA, van der Veen F, Bossuyt PM. Comparison of hysterosalpingography and laparoscopy in predicting fertility outcome. Hum Reprod. 1999;14:1237–1242
  21. World Health Organization. Laboratory manual for the examination of human sperm and sperm-cervical mucous interaction. 5th ed.. Cambridge: Cambridge University Press; 1999;
  22. European Society of Human Reproduction and Embryology (ESHRE) Capri Workshop Group. Anovulatory infertility. Hum Reprod. 1995;10:1549–1553
  23. Chuang CC, Chen CD, Chao KH, Chen SU, Ho HN, Yang YS. Age is a better predictor of pregnancy potential than basal follicle-stimulating hormone levels in women undergoing in vitro fertilization. Fertil Steril. 2003;79:63–68
  24. Maldonano G, Greenland S. Simulation study of confounder-selection strategies. Am J Epidemiol. 1993;138:923–936
  25. Kahn B, Lumey LH, Zybert PA, Lorenz JM, Cleary-Goldman J, D’Alton ME, et al. Prospective risk of fetal death in singleton, twin, and triplet gestations: implications for practice. Obstet Gynecol. 2003;102:685–692
  26. Ombelet W, De Sutter P, Van der Elst J, Martens G. Multiple gestation and infertility treatment: registration, reflection and reaction—the Belgian project. Hum Reprod Update. 2005;11:3–14
  27. Jain T, Missmer SA, Hornstein MD. Trends in embryo-transfer practice and in outcomes of the use of assisted reproductive technology in the United States. N Engl J Med. 2004;350:1639–1645
  28. Spandorfer SD, Arrendondo-Soberon F, Loret de Mola JR, Feinberg RF. Reliability of intraobserver and interobserver sonographic endometrial stripe thickness measurements. Fertil Steril. 1998;70:152–154
  29. Noyes N, Liu HC, Sultan K, Schattman G, Rosenwaks Z. Endometrial thickness appears to be a significant factor in embryo implantation in in-vitro fertilization. Hum Reprod. 1995;10:919–922
  30. Zhang X, Chen CH, Confino E, Barnes R, Milad M, Kazer RR. Increased endometrial thickness is associated with improved treatment outcome for selected patients undergoing in vitro fertilization-embryo transfer. Fertil Steril. 2005;83:336–340
  31. Spandorfer S, Barnhart KT. Endometrial stripe thickness as a predictor of ectopic pregnancy. Fertil Steril. 1996;66:474–477
  32. Friedler S, Schenker JG, Herman A, Lewin A. The role of ultrasonography in the evaluation of endometrial receptivity following assisted reproductive treatments: a critical review. Hum Reprod Update. 1996;2:323–335
  33. Matsui N, Kawano Y, Nakamura S, Miyakawa I. Changes in vascular endothelial growth factor production associated with decidualization by human endometrial stromal cells in vitro. Acta Obstet Gynecol Scand. 2004;83:138–143
  34. Hsieh YY, Tsai HD, Chang CC, Lo HY, Chen CL. Low-dose aspirin for infertilie women with thin endometrium receiving intrauterine insemination: a prospective, randomized study. J Assist Reprod Genet. 2000;17:174–177
  35. Sher G, Fisch JD. Effect of vaginal sildenafil on the outcome of in vitro fertilization after multiple IVF failures attributed to poor endometrial development. Fertil Steril. 2002;78:1073–1076
  36. Unfer V, Casini ML, Costabile L, Mignosa M, Gerli S, DiRenzo GC. High dose of phytoestrogens can reverse the antiestrogenic effects of clomiphene citrate on the endometrium in patients undergoing intrauterine insemination: a randomized trial. J Soc Gynecol Invest. 2004;11:323–328
  37. Abramov Y, Elchalal U, Schenker JG. Obstetric outcome of in vitro fertilized pregnancies complicated by severe ovarian hyperstimulation syndrome: a mulicenter study. Fertil Steril. 1998;70:1070–1076
  38. Wang TH, Horn SG, Chang CL, Wu HM, Tsai YJ, Wans HS, et al. Human chorionic gonadotropin-induced ovarian hyperstimulation syndrome is associated with up-regulation of vascular endothelial growth factor. J Clin Endocrinol Metab. 2002;87:3300–3308
  39. Navot D, Margalioth EJ, Laufer N, Beirkenfeld A, Relou A, Rosler A, et al. Direct correlation between plasma renin activity and severity of the ovarian hyperstimulation syndrome. Fertil Steril. 1987;48:57–61
  40. Navot D, Relou A, Birkenfeld A, Rabinowitz R, Brzezinski A, Margalioth EJ. Risk factors and prognostic variables in the ovarian hyperstimulation syndrome. Am J Obstet Gynecol. 1988;159:210–215
  41. Pinborg A, Lidegaard O, la Cour Freiesleben N, Andersen AN. Consequences of vanishing twins in IVF/ICSI pregnancies. Hum Reprod. 2005;20:2821–2829
  42. Dickey RP. Embryonic loss in iatrogenic multiples. Obstet Gynecol Clin North Am. 2005;32:17–27

 Supported by National Institutes of Health grant T32 for Reproductive Epidemiology to the University of Pennsylvania.

PII: S0015-0282(06)03031-7

doi: 10.1016/j.fertnstert.2006.04.038

Fertility and Sterility
Volume 86, Issue 6 , Pages 1634-1641 , December 2006

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